Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus.

abstract：:Elevations in the plasma levels of glucocorticoids are associated with cognitive impairments that have been ascribed to loss of neurons in the hippocampal formation. However, recent studies have strongly challenged this view. In order to clarify this issue, we have employed for the first time the optical fractionator ...

journal_title：Brain research

authors： Sousa N,Madeira MD,Paula-Barbosa MM

更新日期：1998-06-01 00:00:00

abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

journal_title：Brain research

authors： Li J,Wurtman RJ

更新日期：1999-02-13 00:00:00

abstract：:Recent studies suggest that 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, can have direct effects on blood vessels beyond their cholesterol-lowering effects. We investigated the effects of atorvastatin on the functional and structural properties of blood-brain barrier (BBB) and the act...

journal_title：Brain research

authors： Kalayci R,Kaya M,Elmas I,Arican N,Ahishali B,Uzun H,Bilgic B,Kucuk M,Kudat H

更新日期：2005-05-03 00:00:00

abstract：:Epileptiform activity induced by 4-AP in hippocampal area CA1 is characterised by short recurrent discharges. These are occasionally superimposed by slow field potential (fp) shifts. Simultaneous recordings of fps and [K(+)](o) in area CA1 and temporal cortex showed a slow fp shift in both regions, but associated rise...

journal_title：Brain research

authors： Breustedt J,Gloveli T,Heinemann U

更新日期：2002-11-22 00:00:00

abstract：:The effects of sex steroids on immunoreactive beta-endorphin (EP) release from the rat hypothalamus in vitro were examined using a rat hypothalamic perifusion system and an EP RIA. Testosterone (1-100 ng/ml) and estradiol (10-100 pg/ml) stimulated EP release in a dose-dependent manner. Dehydroepiandrosterone (DHEA, 1-...

journal_title：Brain research

authors： Nakano Y,Suda T,Sumitomo T,Tozawa F,Demura H

更新日期：1991-07-05 00:00:00

abstract：:Impaired learning has been shown as a consequence of isolation-rearing in a variety of paradigms. However, there are situations in which learning in isolation-reared rats is enhanced or unimpaired compared to socially reared rats. The present experiments investigated the effects of isolation rearing on place navigatio...

journal_title：Brain research

authors： Wongwitdecha N,Marsden CA

更新日期：1996-04-09 00:00:00

abstract：:Mice of the BALB/c strain were bilaterally implanted with electrodes in the lateral entorhinal cortex (EC) in order to study the influence of post-trial EC stimulation on memory. The learning task was a food reinforced operant conditioning. At one of several time intervals after a first learning session, the experimen...

journal_title：Brain research

authors： Gauthier M,Destrade C,Soumireu-Mourat B

更新日期：1982-02-11 00:00:00

abstract：:The effect of lactic acidosis on calcium influx, accumulation and efflux was studied in primary cultures of neonatal cortical rat astrocytes. Treatment of cultures with 20 mM sodium lactate, pH 6.0, for 10-60 min resulted in a 35% reduction of 45Ca2+ influx. The decrease in calcium influx was pH dependent because a si...

journal_title：Brain research

authors： Neary JT,Fu Q,Bender AS,Norenberg MD

更新日期：1993-02-26 00:00:00

abstract：:Intracellular recordings were obtained from 212 neurons of the coronal pericruciate cortex of 7 awake, untrained cats. Glass microelectrodes, filled with K+ citrate alone or K+ citrate with either cyclic GMP or 5'-GMP were used for recording and for injecting steady depolarizing and hyperpolarizing currents intracellu...

journal_title：Brain research

authors： Woody CD,Gruen E

更新日期：1978-12-15 00:00:00

abstract：:Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...

journal_title：Brain research

authors： Benardo LS,Prince DA

更新日期：1981-04-27 00:00:00

abstract：:Structures of the medial temporal lobes are recognized to play a central role in memory processing and to be the primary sites of deterioration in Alzheimer disease (AD). Mild cognitive impairment (MCI) represents potentially an intermediate state between normal aging and AD. Proton magnetic resonance spectroscopy (MR...

journal_title：Brain research

authors： Chantal S,Braun CM,Bouchard RW,Labelle M,Boulanger Y

更新日期：2004-04-02 00:00:00

abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...

journal_title：Brain research

authors： Mufson EJ,Labbe R,Stein DG

更新日期：1987-01-13 00:00:00

abstract：:In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...

journal_title：Brain research

authors： Kano T,Katayama Y,Tejima E,Lo EH

更新日期：2000-01-31 00:00:00

abstract：:Cyclic AMP is a second messenger by which different extracellular signals are transduced into biological responses. Within the cell, most of the effects of cAMP are mediated through the cAMP protein kinase which appears to be localized in specific compartments of the cell near to their substrate proteins. In the prese...

journal_title：Brain research

authors： Perez J,Tinelli D,Cagnoli C,Pecin P,Brunello N,Racagni G

更新日期：1993-01-29 00:00:00

abstract：:The suitability of (3H)DPCPX (8-cyclopentyl-1,3-dipropylxanthine), a xanthine derivative, as an vivo probe for labelling adenosine A1 receptors was studied in rats. [3H]DPCPX (nM) penetrated largely into the brain (0.8% of the injected dose per gram of brain tissue 5 min after injection). Brain concentrations stayed a...

journal_title：Brain research

authors： Bisserbe JC,Pascal O,Deckert J,Mazière B

更新日期：1992-12-18 00:00:00

abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...

journal_title：Brain research

authors： Block CH,Siegel A,Edinger H

更新日期：1980-09-15 00:00:00

abstract：:Bilirubin, a product of haemoglobin metabolism, has been suggested to damage neurons by increasing activation of N-methyl-D-aspartate (NMDA) receptors when it reaches high levels in the blood [15,19], as occurs in neonatal jaundice [7]. Bilirubin is also generated in the brain following synthesis of the messenger carb...

journal_title：Brain research

authors： Warr O,Mort D,Attwell D

更新日期：2000-10-06 00:00:00

abstract：:Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...

journal_title：Brain research

authors： Sinatra RS,Ford DH

更新日期：1979-10-19 00:00:00

abstract：:The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-bac...

journal_title：Brain research

authors： Habel U,Koch K,Pauly K,Kellermann T,Reske M,Backes V,Seiferth NY,Stöcker T,Kircher T,Amunts K,Jon Shah N,Schneider F

更新日期：2007-06-04 00:00:00

abstract：:Ion-selective microelectrode techniques were used to study extracellular K+ changes associated with penicillin-induced epileptogenesis in the CA3 region of hippocampal slices. Recordings were made in slices taken from rats 9-16 days of age, which have a pronounced capacity to undergo prolonged synchronized afterdischa...

journal_title：Brain research

authors： Swann JW,Smith KL,Brady RJ

更新日期：1986-12-01 00:00:00

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:In intact guinea pigs a passive horizontal rotation of the body about the fixed head induces compensatory ocular movements (cervico-ocular reflex). When the static neck deviation is maintained, a significant ocular displacement is observed. In acutely hemilabyrinthectomized animals, static body deviation towards the l...

journal_title：Brain research

authors： Pettorossi VE,Petrosini L

更新日期：1984-12-17 00:00:00

abstract：:In the present investigation, electron probe X-ray microanalysis was used to characterize the effects of in vitro ouabain (2 mM) or anoxia on elemental composition (e.g. Na, K, Ca) and water content of rat peripheral (tibial) nerve myelinated axons and Schwann cells. Results showed that independent of axon size, both ...

journal_title：Brain research

authors： Lehning EJ,Doshi R,Stys PK,LoPachin RM Jr

更新日期：1995-10-02 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:Despite a blood-brain barrier for norepinephrine, the concentration of norepinephrine in plasma and cerebrospinal fluid has been observed to be similar. This relationship between plasma and cerebrospinal fluid norepinephrine levels suggest that peripheral sympathetic neurons innervating blood vessels to brain and spin...

journal_title：Brain research

authors： Peskind ER,Raskind MA,Wilkinson CW,Flatness DE,Halter JB

更新日期：1986-03-05 00:00:00

abstract：:Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...

journal_title：Brain research

authors： Roberts GM,Newell F,Simões-Franklin C,Garavan H

更新日期：2008-08-11 00:00:00

abstract：:Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD) even after adjustment for age. Though transgenic mouse models of AD develop AD-related amyloid beta (Abeta) and/or tau pathology, gender differences have not been well documented in these models. In this study, we found that fem...

journal_title：Brain research

authors： Hirata-Fukae C,Li HF,Hoe HS,Gray AJ,Minami SS,Hamada K,Niikura T,Hua F,Tsukagoshi-Nagai H,Horikoshi-Sakuraba Y,Mughal M,Rebeck GW,LaFerla FM,Mattson MP,Iwata N,Saido TC,Klein WL,Duff KE,Aisen PS,Matsuoka Y

更新日期：2008-06-24 00:00:00

abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

journal_title：Brain research

authors： Jalonen T,Holopainen I

更新日期：1989-04-10 00:00:00

abstract：:High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...

journal_title：Brain research

authors： Christie MJ,Bridge S,James LB,Beart PM

更新日期：1985-04-29 00:00:00

abstract：:A combination of electron microscopic autoradiography and immunocytochemistry was used to examine the connections between serotoninergic axons and dopaminergic neurons of the arcuate nucleus of the rat hypothalamus. The serotoninergic elements were identified after selective uptake of tritiated serotonin and the dopam...

journal_title：Brain research

authors： Kiss J,Halász B

更新日期：1986-02-05 00:00:00