Abstract：
:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while the other metabolites, L-phenylalanine and methanol, had no effect at the same concentration. Aspartame caused a significant change in the affinities of L-[3H]glutamate binding without altering the Vmax values of the binding, suggesting the inhibition is competitive. These in vitro findings suggested that aspartame may act directly on the N-methyl-D-aspartate-sensitive glutamate recognition sites in the brain synaptic membranes.
journal_name
Brain Resjournal_title
Brain researchauthors
Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka Mdoi
10.1016/0006-8993(90)91729-zsubject
Has Abstractpub_date
1990-06-18 00:00:00pages
351-3issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91729-Zjournal_volume
520pub_type
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