Abstract:
:Cell number and proliferation of reactive astrocytes were studied quantitatively in the stabbed cerebral cortex of adult mice, using immunohistochemistry for glial fibrillary acidic protein (GFAP) and [3H]thymidine autoradiography. GFAP-positive astrocytes increased in cell number gradually from 24 to 96 h after stabbing, and their immunoreactivity became intense. The maximum number of GFAP-positive cells was about 4.5 times normal in the layers II-VI of the cortex, whereas it was only 1.5 times normal in the layer I (molecular layer). In contrast to the gradual increase in cell number, no GFAP-positive astrocytes were labeled with [3H]thymidine prior to 48 h after stabbing, in either the layer I or the layers II-VI. Then 3-5% of them were labeled at 72 and 96 h, but very few again after 6 days. By injecting [3H]thymidine successively for 6 days after stabbing, only 17% of GFAP-positive astrocytes of the layer I or the layers II-VI were labeled. These results reveal that, in the cortical layers II-VI, many GFAP-negative source cells initially express much more GFAP-antigen without proliferation and change into GFAP-positive reactive astrocytes. Proliferation of reactive astrocytes is not the major factor for the marked increase in number of them. The cortical layer I would have few GFAP-negative source cells for reactive astrocytes. These source cells may be protoplasmic astrocytes.
journal_name
Brain Resjournal_title
Brain researchauthors
Miyake T,Hattori T,Fukuda M,Kitamura T,Fujita Sdoi
10.1016/0006-8993(88)90757-3subject
Has Abstractpub_date
1988-06-07 00:00:00pages
133-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90757-3journal_volume
451pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Aquaporin-4 (AQP4), the prominent water channel in the brain, is particularly concentrated in astrocytic endfeet membranes lining the capillaries and the pia. This localisation pattern makes it well suited to regulate the flow of water and the homeostasis of the interstitial fluid surrounding the neurons. Using immuno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.005
更新日期:2011-01-07 00:00:00
abstract::A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90186-8
更新日期:1989-04-03 00:00:00
abstract::Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.038
更新日期:2005-12-14 00:00:00
abstract::In this study, we observed the chronological alterations of neurofilament 150 (NF-150) immunoreactivity in the gerbil hippocampus and dentate gyrus after 5 min transient forebrain ischemia. NF-150 immunoreactivity in the sham-operated group was mainly detected in mossy fibers and in the hilar region of the dentate gyr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.001
更新日期:2004-07-30 00:00:00
abstract:UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90357-5
更新日期:1988-07-19 00:00:00
abstract::Neurotrophins regulate many aspects of neuronal function and activity. Specifically, the binding of Brain-derived neurotrophic factor (BDNF) to Tyrosine receptor kinase-B (TrkB) or its truncated version, TrkB-T1, can cause growth and differentiation or dominant inhibition of receptor signaling, respectively. There is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.06.008
更新日期:2017-08-15 00:00:00
abstract::Tactile stimulation of the body surface elicited climbing fiber responses in 5% of the 839 Purkinje cells recorded in the caudal posterior vermis (lobules VII-IX) of cats anesthetized with sodium pentobarbital. The cells responsive to tactile stimulation were mainly encountered around the prepyramidal fissure between ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90084-o
更新日期:1990-06-11 00:00:00
abstract::The uptake of amino acids into slices of adult and newborn mouse brain was studied in relation to Na+ flow. (1) The level of Na+ and K+ incubated slices of brain depends on the ionic composition of the incubation medium. The intracellular levels of Na+ in adult tissue are below, in fetal tissue above, Na+ levels in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90763-5
更新日期:1975-02-14 00:00:00
abstract::An immunohistochemical investigation of the bovine pineal gland was performed using both a rabbit polyclonal antibody and a rat monoclonal antibody against choline acetyltransferase (ChAT). A network of ChAT-immunoreactive (IR) nerve fibers was located throughout the pineal gland, both in the perivascular spaces and b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91268-6
更新日期:1991-04-05 00:00:00
abstract::Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90357-x
更新日期:1987-04-07 00:00:00
abstract::Following extirpation of three quarters of the eye anlage of Xenopus laevis in stage 33/34, the remaining quadrants developed into small eyes of normal shape. Irrespective of the different portions of the eye anlage the quarter eyes originated from, the retinotectal projection was always confined to the rostrolateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90089-1
更新日期:1986-09-01 00:00:00
abstract::Recent research suggests that in addition to its prominent role in appetitive learning, the nucleus accumbens (NAC) may also be involved in fear conditioning. In the present study, we investigated whether temporary inactivation of the NAC, by injection of tetrodotoxin (TTX), affects acquisition and expression of condi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.037
更新日期:2004-11-19 00:00:00
abstract::Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90254-0
更新日期:1989-06-26 00:00:00
abstract::Pars interpolaris of the spinal trigeminal nucleus of kittens has been studied with the electron microscope at birth and at several subsequent ages during the first month of life. Attention has been given to ultrastructural maturational changes that occur in this neuropil, especially events in synaptogenesis. The resu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90354-2
更新日期:1978-03-31 00:00:00
abstract::Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147127
更新日期:2020-12-15 00:00:00
abstract::The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90208-5
更新日期:1975-09-12 00:00:00
abstract::Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity. Cyclin-dependent kinase 5 (CDK5) and its activator p35 are required for neurite outgrowth. The cleavage of p35 to p25, mediated by calpain and calcium...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.029
更新日期:2008-03-20 00:00:00
abstract::Intracellular recordings from locus coeruleus neurons grown in explant cultures reveal age-related differences in the responses to iontophoretically applied noradrenaline. Cells grown in culture for more than 26 days exhibit a simple hyperpolarizing response while cells cultured for less than 26 days often have biphas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80238-4
更新日期:1986-03-01 00:00:00
abstract::Systemic endothelin-1 (ET-1) enhances the activity of subfornical organ (SFO) neurons with identified projections to the paraventricular nucleus of the hypothalamus (PVN). The present electrophysiological experiments were undertaken to examine the mechanisms through which systemic ET influences vasopressin secretion. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91378-r
更新日期:1992-07-17 00:00:00
abstract::The purpose of the present study was to determine the effects of chronic (2-month) estradiol (E2) treatment on cholinergic function in the frontal cortex, hippocampus and hypothalamus of the female rat. Chronic E2 treatment selectively increased choline acetyltransferase (ChAT) activity in the frontal cortex and decre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90871-8
更新日期:1990-08-20 00:00:00
abstract::Depolarization by K+ (50 mM) of cultured chick retina cells released 1.14 +/- 0.28% of the accumulated [3H] gamma-aminobutyric acid (GABA) in the absence of Ca2+, but when 1.0 mM Ca2+ was present, the internal free calcium ion concentration [Ca2+]i rose by about 750 nM and the [3H]GABA release about doubled to a value...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90974-e
更新日期:1992-09-18 00:00:00
abstract::We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00644-6
更新日期:1995-09-04 00:00:00
abstract::The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational ag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90314-l
更新日期:1991-08-16 00:00:00
abstract::The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90537-2
更新日期:1985-03-11 00:00:00
abstract::Humans flexibly adapt their behavior using feedback from their environment. This ability is impaired in old age, but recent research suggests this mainly concerns processing of negative feedback and that positive feedback might be spared. The aim of this study was to test this idea of an age-related positivity bias ag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.011
更新日期:2019-08-15 00:00:00
abstract::Both amphetamine and cocaine lead to an intake pattern in chronic addicts in which the drug is taken repeatedly over prolonged periods. While continuously administered amphetamines, designed to mimic this intake pattern, have a neurotoxic effect on caudate dopamine terminals, several studies have failed to find simila...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90207-p
更新日期:1992-12-11 00:00:00
abstract::Ethanol administration in long-sleep (LS) and short-sleep (SS) mice results in a large number of Fos-IR neurons in the supraoptic nucleus (SON) in LS, and almost no Fos-IR neurons in the same nucleus in SS mice. In contrast, isotonic saline, hypertonic saline, with or without ethanol, resulted in a similar pattern of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02453-8
更新日期:2002-05-10 00:00:00
abstract::10-fold higher doses in SW mice. Furthermore, cotreatment of 129/SvEv mice with morphine plus a low dose of naltrexone (ca. 0.1 microgram/kg) that markedly enhances and prolongs morphine's antinociceptive effects in SW mice did not enhance, and often attenuated6 h. The marked GM1-induced attenuation of morphine's anti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02446-4
更新日期:2000-02-21 00:00:00
abstract::Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00904-3
更新日期:1996-11-25 00:00:00
abstract::The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02919-0
更新日期:2002-08-23 00:00:00