Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat.

Abstract:

:The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learning, etc.) for LC. We report that at least 40% of all LC neurons project to the olfactory bulb; the projection is almost 10 times greater than to any other part of the cerebral cortex. This unsuspectedly rich LC-olfactory bulb connection is consistent with current theories which implicate LC neurons in heightened sensory vigilance and trophic regulation of connectional development and plasticity.

journal_name

Brain Res

journal_title

Brain research

authors

Shipley MT,Halloran FJ,de la Torre J

doi

10.1016/0006-8993(85)90537-2

subject

Has Abstract

pub_date

1985-03-11 00:00:00

pages

294-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(85)90537-2

journal_volume

329

pub_type

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