Abstract:
:The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learning, etc.) for LC. We report that at least 40% of all LC neurons project to the olfactory bulb; the projection is almost 10 times greater than to any other part of the cerebral cortex. This unsuspectedly rich LC-olfactory bulb connection is consistent with current theories which implicate LC neurons in heightened sensory vigilance and trophic regulation of connectional development and plasticity.
journal_name
Brain Resjournal_title
Brain researchauthors
Shipley MT,Halloran FJ,de la Torre Jdoi
10.1016/0006-8993(85)90537-2subject
Has Abstractpub_date
1985-03-11 00:00:00pages
294-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90537-2journal_volume
329pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In WAG/Rij rat genetic model of absence epilepsy, the first spike-wave discharges (EEG hallmark of absence epilepsy) are known to appear after puberty, and their incidence increases with age. WAG/Rij rats are known to have a genetic predisposition to absence epilepsy, and further development of epilepsy might be influ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.067
更新日期:2015-01-12 00:00:00
abstract::Bilateral microinjection of kainic acid (30-117 pmol) into the substantia nigra induced convulsive seizures resembling those elicited from limbic system structures. The convulsive seizures, which consisted of facial and forelimb clonus with rearing and falling, developed after a latency of more than 30 min and were pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91661-y
更新日期:1990-10-01 00:00:00
abstract::Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90058-6
更新日期:1978-01-06 00:00:00
abstract::The development of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous system. The rat pilocarpine model of epilepsy was utilized to study persistent alterations in calcium/calmodulin-dependent kinase II (CaM kinase II) activity associated with epileptogenesis. CaM kinase II-dependen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02623-8
更新日期:2000-09-01 00:00:00
abstract::When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90076-2
更新日期:1982-10-14 00:00:00
abstract::Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01572-3
更新日期:1999-07-31 00:00:00
abstract::The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01278-p
更新日期:1995-02-20 00:00:00
abstract::The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91264-s
更新日期:1993-08-06 00:00:00
abstract::The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90393-7
更新日期:1984-07-23 00:00:00
abstract::Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91274-v
更新日期:1993-08-06 00:00:00
abstract::The cat substantia nigra (SN) pars reticulata (SNR) has been observed electron microscopically after ibotenic acid injections into the caudate nucleus (Cd) and horseradish peroxidase injections into the nucleus tegmenti pedunculopontinus pars compacta (TPC). As a result, degenerating striatal terminals were found to m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90683-5
更新日期:1989-04-17 00:00:00
abstract::This study examined the projection from the rostral nucleus of the solitary tract (rNST) to the medial parabrachial nucleus (mPBN) in male Wistar rats using DiI as a retrograde tracer and biotinylated dextran as an anterograde tracer. Following successful unilateral injection of DiI into the mPBN (n = 8), retrogradely...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00736-6
更新日期:1996-10-21 00:00:00
abstract::Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91761-g
更新日期:1993-03-12 00:00:00
abstract::The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90682-3
更新日期:1989-04-17 00:00:00
abstract::By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90957-7
更新日期:1987-08-18 00:00:00
abstract::The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90151-3
更新日期:1984-09-24 00:00:00
abstract::Administration of either Tyr-D-Ala-Gly-MePhe-Gly(ol) (DAGO), a mu-opioid agonist, or nicotine into the VTA (A10) caused an increase in both dopamine (DA) and its metabolite levels in both the A10 region and DA nerve terminals in the nucleus accumbens of rats when assessed with dual probe brain dialysis. These findings...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90087-4
更新日期:1993-10-08 00:00:00
abstract::The median preoptic nucleus (MnPN) of the hypothalamus contains sleep-active neurons including sleep-active GABAergic neurons and is involved in the regulation of nonREM/REM sleep. The hypocretinergic (HCRT) neurons of the perifornical-lateral hypothalamic area (PF-LHA) and serotonergic (5-HT) neurons of the dorsal ra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.115
更新日期:2008-10-09 00:00:00
abstract::The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.045
更新日期:2008-11-06 00:00:00
abstract::Previous research has shown that hippocampal and neocortical activation accompanies the postural changes occurring during self-grooming in rats but is absent or reduced during the stereotyped components of grooming, including head-washing and licking or biting. Since electrocortical activation is dependent on ascendin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01743-6
更新日期:1999-08-14 00:00:00
abstract::Intracellular recordings were made from rabbit nodose ganglion cells in vitro. Morphine (up to 100 micro M), normorphine (up to 10 micro M) and D-Ala2, Leu5-enkephalin (DADLE) (up to 5 micro M) each had no detectable effect on the electrical properties of the cell membrane, except for local anesthetic-like actions at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91066-0
更新日期:1981-09-21 00:00:00
abstract::The content of the mRNAs that code for prepro-corticotropin releasing hormone (ppCRH), prepro-neurotensin/neuromedin N (ppNT/NMN) and prepro-enkephalin (ppENK) was measured using in situ hybridization histochemistry in the various subdivisions of the hypothalamic paraventricular nucleus (PVH) 4 h after a bout of ether...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90080-f
更新日期:1991-03-29 00:00:00
abstract::Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90428-e
更新日期:1990-04-23 00:00:00
abstract::We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluoresc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91106-q
更新日期:1990-04-09 00:00:00
abstract::Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91593-3
更新日期:1986-03-05 00:00:00
abstract::In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01375-3
更新日期:1997-02-21 00:00:00
abstract::The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91476-4
更新日期:1987-10-27 00:00:00
abstract::Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00797-t
更新日期:1995-10-30 00:00:00
abstract::Facilitation of cerebellorubral transmission was illustrated in nembutalized cats on paired stimulation of the cerebellar nucleus interpositus by an example of monosynaptic EPSPs of the rubrospinal neurons. It was found that the facilitation stated is not determined by the change in the presynaptic volley of impulses....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90334-9
更新日期:1987-05-05 00:00:00
abstract::Systemic injection of kainic acid (KA) in adult rat elicits a pattern of neuronal pathology which exhibits several features of human temporal lobe epilepsy. KA-induced seizure activity is accompanied by the activation of the calcium-dependent protease calpain in limbic structures. In the present study, we evaluated th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01360-1
更新日期:1996-07-08 00:00:00