Abstract:
:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of subunits found in EW neurons. Of particular note, GluR2 immunoreactivity was present in the vast majority (ca. 80%) of neurons of pigeon EW but was found in only a small fraction (ca. 15%) of chick EW neurons. Scarcity of the GluR2 subunit in chick EW was confirmed by in situ hybridization. Because of the tendency for parvalbumin to be localized to neurons that are selectively deficient in GluR2, we also studied the localization of parvalbumin, as well as other calcium-binding proteins, in EW of chick and pigeon. Parvalbumin was found in more than 50% of chick EW neurons but was not detected in pigeon EW neurons. Our results suggest that there are major glutamatergic inputs to EW neurons in both pigeons and chicks. Furthermore, there are likely to be more AMPA-type calcium-permeable glutamate receptors in EW neurons of chick than in pigeon, since it is known that the subtype containing the edited GluR2 subunit is not calcium permeable.
journal_name
Brain Resjournal_title
Brain researchauthors
Toledo CA,Britto LR,Pires RS,Veenman CL,Reiner Adoi
10.1016/s0006-8993(02)02919-0subject
Has Abstractpub_date
2002-08-23 00:00:00pages
122-30issue
1eissn
0006-8993issn
1872-6240pii
S0006899302029190journal_volume
947pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00990-0
更新日期:1996-10-28 00:00:00
abstract::Here we describe a sustained outward potassium current (IK) in retinal horizontal cells (HCs). IK is unusually small over the range of membrane potentials normally experienced by these cells, which are chronically depolarized. We hypothesize that this unique IK will reduce the amount of neurotransmitter required to sh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90204-o
更新日期:1990-09-24 00:00:00
abstract::The electroretinogram (ERG) of the dark-adapted goldfish was examined before and after intravitreal injection of DL-2-amino-4-phosphonobutyric acid (APB). APB abolished the b-wave and decreased absolute sensitivity of the remaining waveform, which was composed of a vitreal-negative component followed by a vitreal-posi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91194-3
更新日期:1989-03-20 00:00:00
abstract::Fast axoplasmic transport was examined in experimental nerve ligation and adriamycin-induced neuronal perikaryon lesions. Animals were sacrificed at precisely 3 and 4 h following the injection of [3H]leucine. In single ligated nerves, the 3 and 4 h down-flow rates, which include the time for neuronal processing of lab...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90730-3
更新日期:1979-07-27 00:00:00
abstract::The anatomical structure of the basal ganglia indicates that the input from the cerebral cortex is funnelled through the striatum to the globus pallidus and substantia nigra. This structure implies integration of the information as it is transferred through the basal ganglia. In order to investigate this integration, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90363-4
更新日期:1985-11-25 00:00:00
abstract::Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91108-6
更新日期:1989-10-02 00:00:00
abstract::We report here the in vivo effects of estrogen (E2) on modulation of synaptic plasticity and the agonistic (estrogen-like) role of selective estrogen receptor modulator (SERM), tamoxifen (TAM) in the CA1 of the rat hippocampus. Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.027
更新日期:2007-02-09 00:00:00
abstract::The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. CSF production was measured by the ventriculo-cisternal perfusion method with Blue dextran 2000 used as an indicat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91027-c
更新日期:1992-10-23 00:00:00
abstract::Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.086
更新日期:2005-06-28 00:00:00
abstract::Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90027-3
更新日期:1988-06-14 00:00:00
abstract::In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01054-8
更新日期:1997-12-19 00:00:00
abstract::In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91316-s
更新日期:1991-06-07 00:00:00
abstract::In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91330-8
更新日期:1987-06-23 00:00:00
abstract::The effect of five daily intraperitoneal (i.p.) injections of NT69L on in vitro dopamine release, uptake, and [(3)H]NT binding in rat striatal tissue was investigated. NT69L perfusion increased K(+)-evoked and electrically evoked [(3)H]DA release. NT receptor-1 antagonist SR48692 inhibited the stimulatory effect of NT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.069
更新日期:2004-10-29 00:00:00
abstract::Sleep spindles may be involved in synaptic plasticity. Learning-dependent increases in spindles have been observed in both humans and rats. In humans, the innate (i.e., baseline) number of spindles correlate with measures of academic potential such as Intelligence Quotient (IQ) tests. The present study investigated if...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.026
更新日期:2010-03-10 00:00:00
abstract::The serotonin neurotoxin, 5,6-dihydroxytryptamine (5,6-DHT), was injected into the body cavity of snails. Changes induced in the central nervous system (CNS) by the neurotoxin were studied by morphological, electrophysiological and biochemical techniques for up to 90 days following injection. The neurotoxin induced a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90251-4
更新日期:1992-04-24 00:00:00
abstract::During a simple reaction time task using auditory or visual stimuli, a total of 96 single units were recorded from the dorsolateral prefrontal cortex of macaque monkeys. These monkeys were trained to depress a lever for a fixed period which produced a tone burst or a small spot of light. After a variable period, the s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91025-3
更新日期:1982-09-09 00:00:00
abstract::Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.002
更新日期:2019-02-01 00:00:00
abstract::Our recent researches have identified increased expression of miR-21-5p in rats brain following traumatic brain injury (TBI), which protected against blood-brain barrier (BBB) damage. To further study the mechanism underlying the role of miR-21-5p on alleviating BBB damage after TBI, we performed the scratch injury mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.015
更新日期:2016-11-01 00:00:00
abstract::Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01500-0
更新日期:1996-04-22 00:00:00
abstract::Collagen is one of the best materials used for nerve guide preparation due to its biocompatibility and desirable tensile strength. In this work, we have compared regeneration and functional reinnervation after sciatic nerve resection with bioresorbable crosslinked collagen guides in 10 mm gap. The crosslinking was car...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.03.022
更新日期:2005-06-07 00:00:00
abstract::Missense mutations of presenilin 1 (PS-1) and presenilin 2 (PS-2) genes cause the majority of early-onset familial forms of Alzheimer's disease (AD). We previously characterized the distribution of the PS-1 protein in the mouse brain by immunohistochemistry using an antibody directed against an epitope located in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00231-x
更新日期:1997-05-30 00:00:00
abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90163-9
更新日期:1984-04-01 00:00:00
abstract::To gain greater insight on the molecular mechanisms that underlie ischemic stroke, we compared gene expression profiles in transient (tMCAO) and permanent middle cerebral artery occlusion (pMCAO) stroke models using Expression Analysis Systematic Explorer (EASE) pathway analysis software. Many transcripts were induced...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.090
更新日期:2006-02-03 00:00:00
abstract::The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02777-3
更新日期:2000-10-13 00:00:00
abstract::In epilept WAG/Rij rats, multiple unit activity coinciding with the occurrence of spike-wave discharges was recorded under neurolept anesthesia. Recordings were made in the frontal cortex and in various nuclei of the thalamus, in specific nuclei such as the ventroposterolateral, the ventroposteromedial and the ventrol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91641-5
更新日期:1993-05-28 00:00:00
abstract::Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.056
更新日期:2010-07-30 00:00:00
abstract::The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90015-x
更新日期:1983-12-19 00:00:00
abstract::The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90663-2
更新日期:1984-01-16 00:00:00
abstract::Recent immunohistochemical studies have suggested that the forebrain distribution of stigmoid bodies, marked by an antibody against placental aromatase-associated antigen X-P2 (PAX), overlaps with that of the common binding sites of androgen and estrogen. In the present light- and electron-microscopy study the coexist...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91933-x
更新日期:1994-01-21 00:00:00