Abstract：
:Collagen is one of the best materials used for nerve guide preparation due to its biocompatibility and desirable tensile strength. In this work, we have compared regeneration and functional reinnervation after sciatic nerve resection with bioresorbable crosslinked collagen guides in 10 mm gap. The crosslinking was carried out either with glutaraldehyde (GTA) or microwave irradiation (MWI). The multilayered collagen membrane used for nerve guides are prepared by lamellar evaporation technique. Functional evaluations of the regenerated nerves were performed by measuring the sciatic functional index (SFI), nerve conduction velocity (NCV), and electromyography (EMG). Transmission electron microscopic studies showed growth of axonal cable with fewer myelinated axons, Schwann cells and more unmyelinated axons present in the case of group treated with uncrosslinked collagen tubes after 1 month of implantation. However, we have observed more myelinated axons in the case of autograft, GTA, and MWI crosslinked collagen tube implants across the gap of 1 cm after the same period of implantation. Smaller myelinated fiber diameter was observed in the case of GTA crosslinked collagen tube group when compared with the autograft and MWI collagen tube groups. There were more myelinated axons during the 3rd and 6th months postoperatively using these conduits as substantiated by light microscopic studies of the regenerated nerve. The conduction velocity and recovery index improved significantly after 5 months reaching the normal values in the autograft and MWI crosslinked collagen groups compared to GTA and uncrosslinked collagen tubes.
journal_name
Brain Resjournal_title
Brain researchauthors
Ahmed MR,Vairamuthu S,Shafiuzama M,Basha SH,Jayakumar Rdoi
10.1016/j.brainres.2005.03.022subject
Has Abstractpub_date
2005-06-07 00:00:00pages
55-67issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00444-0journal_volume
1046pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90864-9
更新日期：1985-11-04 00:00:00
abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
abstract：:A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02461-6
更新日期：2000-07-21 00:00:00
abstract：:Glucocorticoids (GC) provide neuroprotection and early recovery after spinal cord injury (SCI). While several mechanisms were proposed to account for these effects, limited information exists regarding GC actions in sensory areas of the spinal cord. Presently, we studied the time course of Fos expression, and reduced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02717-2
更新日期：2001-09-07 00:00:00
abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90125-2
更新日期：1984-11-26 00:00:00
abstract：:Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.11.030
更新日期：2019-03-15 00:00:00
abstract：:Neurological problems can develop when blood glucose levels rapidly rise or fall yet there has been little experimentation at a cellular level to assess how neurophysiological change may be induced. Using intracellular recording in the rat neocortical slice preparation, we examined pyramidal neurons of layers II-III a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90859-t
更新日期：1991-07-26 00:00:00
abstract：:Antibody has been prepared to purified neurofilament protein extracted from calf brain. This antibody crossreacts with brain and nerve extracts from all mammals tested but fails to crossreact with frog, cod and chicken nerve extracts. Thus the serologic homology of these neurofilament proteins appears to be restricted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)91074-5
更新日期：1977-10-07 00:00:00
abstract：:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (I...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00343-0
更新日期：1997-06-13 00:00:00
abstract：:Responses of subthalamic neurons (STN) to the iontophoretic application of glutamate (Glu), acetylcholine (ACh) and GABA were studied in rats 2 or 3 weeks following bilateral decortication, and were compared to those obtained in normal animals. All the cells recorded in lesioned rats showed a decrease in their spontan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90077-1
更新日期：1987-02-17 00:00:00
abstract：:In primary neuron cultures obtained from ventral mesencephalon of mouse fetuses, approximately 10-30% of the neurons were dopaminergic, as demonstrated by a rapid glyoxylic acid histofluorescence procedure, and another 10-30% were GABAergic as demonstrated by autoradiography. Resting membrane potentials averaged -58 m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90024-7
更新日期：1988-04-01 00:00:00
abstract：:Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.086
更新日期：2010-08-06 00:00:00
abstract：:To investigate whether differences in vulnerability to free radicals might underlie differences among striatal neurons in their vulnerability to neurodegenerative processes such as occur in ischemia and Huntington's disease, we have analyzed the localization of superoxide free radical scavengers in different striatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01320-2
更新日期：1996-02-05 00:00:00
abstract：OBJECTIVE:Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.074
更新日期：2009-01-23 00:00:00
abstract：:The septo-hippocampal pathway contains a major gamma-aminobutyric acid (GABA) projection to dendritic fields within the hippocampus. To determine the importance of the septo-hippocampal pathway in ischemia-induced accumulation of GABA and subsequent cell death in area CA1 of hippocampus, septo-hippocampal deafferentat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01415-7
更新日期：1998-03-02 00:00:00
abstract：:An in vitro method was developed to separately visualize dopaminergic, noradrenergic and serotoninergic terminals in the cerebral, hippocampal and cerebellar cortices of the rat, by means of the glyoxylic histochemical fluorescence method. Animals were pretreated with alpha-methylparatyrosine to deplete catecholamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90770-9
更新日期：1978-05-19 00:00:00
abstract：:Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.063
更新日期：2015-07-01 00:00:00
abstract：:Awake, intact monkeys were trained to perform discrete flexion or extension movements of the hand about the wrist in response to visual signals. The object of the movement was to align a cursor, coupled to a manipulandum, on a target line. Cursor and target lines are displayed on a video monitor placed in front of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90726-0
更新日期：1982-03-25 00:00:00
abstract：:Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91893-7
更新日期：1994-03-21 00:00:00
abstract：:William James noted that memories could persist from minutes to weeks. This essay attempts to explain this variation by situating the explanation in the biochemistry of dendritic spines. Two outcomes are critical to generate the synaptic basis of memory: (1) the actin cytoskeleton in the spine must be degraded to perm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.12.009
更新日期：2015-09-24 00:00:00
abstract：:Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90195-x
更新日期：1982-08-01 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：:Interactive-activation models posit that visual word recognition involves co-activation of orthographic neighbors (e.g., note, node) and competition among them via lateral inhibitory connections. Behavioral evidence of this lexical competition comes from masked priming paradigms, in which target words elicit slower re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.029
更新日期：2018-04-15 00:00:00
abstract：:Zif268 transcription factor is expressed throughout Cebus apella visual cortex at high basal levels. Monocular eyelid suture alters the levels of Zif268 on neurons connected to the deprived eye, revealing ocular dominance columns in the striate cortex of Cebus as previously demonstrated in Old World monkeys (Chaudhuri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00590-2
更新日期：1996-09-02 00:00:00
abstract：:Unilateral 6-hydroxydopamine (6-OHDA) lesions of substantia nigra pars compacta (SNPC) neurons in rats induce behavioural hypersensitivity to dopaminergic agonists. However, the role of specific dopamine receptors is unclear, and potential alterations in their transduction mechanisms remain to be evaluated. The presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02927-4
更新日期：2001-11-30 00:00:00
abstract：:Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91108-6
更新日期：1989-10-02 00:00:00
abstract：:The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00313-7
更新日期：1996-09-30 00:00:00
abstract：:This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.04.045
更新日期：2016-07-01 00:00:00
abstract：:The role of cat's primary auditory cortex (AI) in both pattern discrimination and sound localization has been demonstrated by observing that ablations of it disrupt these functions. This research studied effective connectivity variations as a function of modifications in the temporal pattern of acoustic stimulation. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91542-9
更新日期：1988-05-31 00:00:00
