Abstract：
OBJECTIVE:Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address this issue by quantifying EEG-EMG coherence at times when muscles experienced minimal versus significant fatigue. METHODS:Nine healthy subjects sustained an isometric elbow flexion at 30% maximal level until exhaustion while their brain (EEG) and muscle (EMG) activities were recorded. The entire duration of the EEG and EMG recordings was divided into the first half (stage 1 with minimal fatigue) and second half (stage 2 with severer fatigue). The EEG-EMG coherence and power spectrum in each stage was computed. RESULTS:The power of both EEG and EMG increased significantly while their coherence decreased significantly in stage 2 compared with stage 1 at beta (15-35 Hz) band. CONCLUSIONS:Despite an elevation of the power for both the EEG and EMG activities with muscle fatigue, the fatigue weakens strength of brain-muscle signal coupling at beta frequency band. SIGNIFICANCE:Weakening of corticomuscular coupling may be a major neural mechanism contributing to muscle fatigue and associated performance impairment.
journal_name
Brain Resjournal_title
Brain researchauthors
Yang Q,Fang Y,Sun CK,Siemionow V,Ranganathan VK,Khoshknabi D,Davis MP,Walsh D,Sahgal V,Yue GHdoi
10.1016/j.brainres.2008.10.074subject
Has Abstractpub_date
2009-01-23 00:00:00pages
101-12eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02626-7journal_volume
1250pub_type
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