Abstract：
:The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significantly increased in the 6-OHDA lesioned SN, compared with the intact contralateral SN, and the SN of normal control rats injected with ascorbic acid, which showed no significant difference in iron levels between injected and non-injected sides. In both 6-OHDA lesioned and ascorbic acid injected SN, there were no alterations in the levels of calcium, magnesium, copper and zinc. In the 6-OHDA lesioned SN there was an almost complete loss of tyrosine hydroxylase positive cells in the SN. These results suggested that the 6-OHDA induced dopaminergic cell death may be related to the increased iron.
journal_name
Brain Resjournal_title
Brain researchauthors
He Y,Thong PS,Lee T,Leong SK,Shi CY,Wong PT,Yuan SY,Watt Fdoi
10.1016/0006-8993(96)00313-7subject
Has Abstractpub_date
1996-09-30 00:00:00pages
149-53issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(96)00313-7journal_volume
735pub_type
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