Modulation of hypoxic depressions of ventilatory activity in the newborn piglet by mesencephalic mechanisms.

Abstract:

:In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic level exhibited these hypoxia-induced depressions. These depressions were lessened following transection through the caudal mesencephalon. Mesencephalic mechanisms play a fundamental role in the brainstem regulation of ventilatory responses to hypoxia.

journal_name

Brain Res

journal_title

Brain research

authors

St-John WM,St Jacques R,Li A,Darnall RA

doi

10.1016/s0006-8993(98)01310-9

subject

Has Abstract

pub_date

1999-02-20 00:00:00

pages

147-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(98)01310-9

journal_volume

819

pub_type

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