PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes.

abstract：:The distribution of [125I]hCGRP alpha binding sites was studied in tissue sections from rat brain and, at the level of the nucleus accumbens in the brains of 6 other species. In the rat, very high levels of binding were found in the nucleus accumbens, the amygdaloid complex and mammillary body while high amounts were ...

journal_title：Brain research

authors： Dennis T,Fournier A,Guard S,St Pierre S,Quirion R

更新日期：1991-01-18 00:00:00

abstract：:To evaluate roles of the sympathetic nervous system in enhancing glucose uptake in skeletal muscles in response to electrical stimulation of the ventromedial hypothalamic nucleus (VMH), the effects of guanethidine treatment and adrenal demedullation on the response were examined in rats anesthetized and injected with ...

journal_title：Brain research

authors： Minokoshi Y,Okano Y,Shimazu T

更新日期：1994-06-27 00:00:00

abstract：:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...

journal_title：Brain research

authors： Sawchenko PE

更新日期：1987-12-29 00:00:00

abstract：:Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronical...

journal_title：Brain research

authors： Casey KL,Morrow TJ

更新日期：1989-10-30 00:00:00

abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...

journal_title：Brain research

authors： Maguire CM,Geraghty DP

更新日期：1998-03-09 00:00:00

abstract：:As in many humans suffering from lupus erythematosus, the development of systemic autoimmunity and inflammation in Fas-deficient MRL-lpr mice is accompanied by CNS dysfunction of unknown etiology. Experimental studies revealed infiltration of lymphoid cells into the choroid plexus, reduced neuronal complexity, retarde...

journal_title：Brain research

authors： Ballok DA,Millward JM,Sakic B

更新日期：2003-02-28 00:00:00

abstract：:Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...

journal_title：Brain research

authors： Blanco-Centurion CA,Salin-Pascual RJ

更新日期：2001-12-27 00:00:00

abstract：:The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...

journal_title：Brain research

authors： Besheer J,Schroeder JP,Stevenson RA,Hodge CW

更新日期：2008-09-26 00:00:00

abstract：:In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomi...

journal_title：Brain research

authors： Zhang X,Wu J,Liu H,Zhang X

更新日期：2013-04-24 00:00:00

abstract：:With the use of [3H]p-aminoclonidine (PAC), alpha 2-adrenergic binding sites were mapped in the brain of the Japanese quail (Coturnix coturnix japonica). The sites were labeled with the use of in vitro quantitative autoradiography. Special attention was given to areas implicated in the control of sexually dimorphic re...

journal_title：Brain research

authors： Ball GF,Nock B,McEwen BS,Balthazart J

更新日期：1989-07-03 00:00:00

abstract：:The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...

journal_title：Brain research

authors： Canu MH,Langlet C,Dupont E,Falempin M

更新日期：2003-07-18 00:00:00

abstract：:The carotid body of the mouse is ideally suited for in vitro photometric and fluorometric studies using transillumination. It is small, thin and translucent. Photometric recordings were made by using a dual wavelength method. Wavelengths of 550 nm (maximal absorbance, MA) and 540 nm (isosbestic point, IP) were employe...

journal_title：Brain research

authors： Acker H,Eyzaguirre C,Goldman WF

更新日期：1985-03-18 00:00:00

abstract：:Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(ΔE9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mic...

journal_title：Brain research

authors： Kalifa S,Polston EK,Allard JS,Manaye KF

更新日期：2011-02-28 00:00:00

abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...

journal_title：Brain research

authors： Arai A,Vanderklish P,Kessler M,Lee K,Lynch G

更新日期：1991-08-02 00:00:00

abstract：:Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...

journal_title：Brain research

authors： Nagy A,Eder K,Selak MA,Kalman B

更新日期：2015-01-21 00:00:00

abstract：:The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations...

journal_title：Brain research

authors： Pohorecki R,French J,Domino EF

更新日期：1987-09-08 00:00:00

abstract：:We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...

journal_title：Brain research

authors： Dube MG,Kalra PS,Crowley WR,Kalra SP

更新日期：1995-09-04 00:00:00

abstract：:Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...

journal_title：Brain research

authors： Morio Y,Tanimoto H,Yakushiji T,Morimoto Y

更新日期：1994-02-21 00:00:00

abstract：:Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...

journal_title：Brain research

authors： Piazza PV,Rougé-Pont F,Deminière JM,Kharoubi M,Le Moal M,Simon H

更新日期：1991-12-13 00:00:00

abstract：:Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-co...

journal_title：Brain research

authors： Moragues N,Ciofi P,Lafon P,Tramu G,Garret M

更新日期：2003-03-28 00:00:00

abstract：:Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...

journal_title：Brain research

authors： Westerink RH,Beekwilder JP,Wadman WJ

更新日期：2012-04-23 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:Computer-assisted morphometrics were used to characterize mature somatodendritic architecture in Golgi-stained neurons of the entopeduncular nucleus (EN) of the adult cat. Only one form of adult EN neuron was apparent and characterized by common features including: relatively large conical somata, long aspiny and mode...

journal_title：Brain research

authors： Dvergsten CL,Hull CD,Levine MS,Adinolfi AM,Fisher RS,Buchwald NA

更新日期：1986-06-11 00:00:00

abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...

journal_title：Brain research

authors： Olivier V,Guibert B,Leviel V

更新日期：1995-10-09 00:00:00

abstract：:We have studied in adult rats bearing a unilateral nigral lesion the effect of nigral grafts into the striatum on behavioral supersensitivity induced by chronic treatment of L-DOPA (100 mg/kg i.p.) plus benserazide (50 mg/kg i.p.). Repeated administration of L-DOPA increases contraversive circling. In rats without gra...

journal_title：Brain research

authors： Gaudin DP,Rioux L,Bédard PJ

更新日期：1990-01-01 00:00:00

abstract：:Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands i...

journal_title：Brain research

authors： Cheng RK,Williams CL,Meck WH

更新日期：2008-10-27 00:00:00

abstract：:Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...

journal_title：Brain research

authors： Abul M,Al-Bader MD,Mouihate A

更新日期：2019-03-15 00:00:00

abstract：:The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...

journal_title：Brain research

authors： Aronin N,Difiglia M,Graveland GA,Schwartz WJ,Wu JY

更新日期：1984-05-23 00:00:00

abstract：:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compa...

journal_title：Brain research

authors： Mikkelsen JD,Jensen JB,Engelbrecht T,Mørk A

更新日期：1999-12-18 00:00:00

abstract：:Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...

journal_title：Brain research

authors： Cannizzaro C,Martire M,Cannizzaro E,Provenzano G,Gagliano M,Carollo A,Mineo A,Steardo L

更新日期：2001-06-22 00:00:00