Abstract：
:We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2.35+/-0.9 microg/ml which is in the observed range reported for glutamate uptake blockers. Tx4-7, one of PhTx4 toxins, showed the strongest inhibitory activity (50.3+/-0.69%, n=3).
journal_name
Brain Resjournal_title
Brain researchauthors
Mafra RA,Figueiredo SG,Diniz CR,Cordeiro MN,Cruz JD,De Lima MEdoi
10.1016/s0006-8993(99)01472-9subject
Has Abstractpub_date
1999-06-12 00:00:00pages
297-300issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899399014729journal_volume
831pub_type
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