Abstract：
:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal labeling in geniculostriate fibers and in tectoparabigeminal terminals was observed as early as P1 and showed little change with eye-opening. However, at early ages, consistent transneuronal labeling was found to require injection of up to 4 times the amount of tracer (0.18 mg WGA-HRP) as adults (0.04 mg WGA-HRP), delivered in two injections. Control injections of HRP alone produced heavy anterograde labeling at all ages, without requiring increased injections. The results suggest that transneuronal transport precedes synaptic transmission, and may illustrate a mechanism for exchanging molecules between neurons. One explanation for the requirement of increased tracer is that axonal and/or transneuronal transport of WGA-HRP may be selectively limited to certain cells in the postnatal retina.
journal_name
Brain Resjournal_title
Brain researchauthors
Itaya SKdoi
10.1016/0165-3806(88)90087-9subject
Has Abstractpub_date
1988-01-01 00:00:00pages
83-8issue
1eissn
0006-8993issn
1872-6240journal_volume
466pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.053
更新日期：2016-10-01 00:00:00
abstract：:The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91622-8
更新日期：1991-01-25 00:00:00
abstract：:Focal cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators (Clark et al., Brain Res. Bull., 35 (1994) 387-392; Garcia et al., Am. J. Pathol., 144 (1994) 188-199; Wang et al., J. Neurochem. 71 (1998) 1194-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02328-9
更新日期：2001-06-01 00:00:00
abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91137-p
更新日期：1991-05-10 00:00:00
abstract：:Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90546-2
更新日期：1983-10-03 00:00:00
abstract：:Electrical stimulation of the retina evokes at the optic tract level rhythmic bursts of activity whose temporal structure is predictable from the polarity of the stimulation and the receptive field type. The reaction of lateral geniculate units to this input was studied in fast and slow relay cells as well as in inter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90135-x
更新日期：1978-08-18 00:00:00
abstract：:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00512-5
更新日期：1998-08-03 00:00:00
abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90129-7
更新日期：1989-12-25 00:00:00
abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01461-3
更新日期：1998-03-09 00:00:00
abstract：:Extracellular single-unit activity was recorded from neurons of the internal and external pallidal segments, and from 'border cells' at the periphery of the segments, in 3 waking cynomolgus monkeys during electrical stimulation of 3 sites bilaterally in the striatum: one in the caudate nucleus and two in the putamen. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90394-6
更新日期：1989-09-25 00:00:00
abstract：:In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.039
更新日期：2011-06-29 00:00:00
abstract：:Rabbit retina was used as a model to study the possible role of taurine in the retina. The taurine-synthesizing enzyme, cysteine sulfinic acid decarboxylase (CSAD), is localized immunohistochemically using specific antibodies against CSAD. The CSAD-immunoreactivity appears to be most prominent in the inner nuclear lay...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90066-6
更新日期：1985-07-01 00:00:00
abstract：:Extracellular single unit recordings were made from various depths in the left olfactory bulb of ten anaesthetised, freely breathing adult hens (Gallus domesticus) using glass insulated tungsten microelectrodes. The 66 spontaneously active neurons recorded had widely variable firing rates (mean 4.9 spikes/s, range 0.1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03376-5
更新日期：2002-03-01 00:00:00
abstract：:In anesthetized, artificially ventilated cats, pretreated with the muscarinic antagonist scopolamine, the effect of naloxone on the efficacy of nicotinic transmission in the superior cervical ganglion was used as a test of endogenous opioid release by the preganglionic axons. The cervical sympathetic trunk (CST) was s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91102-7
更新日期：1991-05-10 00:00:00
abstract：:After-effects of fusimotor action on dynamic sensitivity of spindle primary afferents from soleus resulted from low rate stimulation of both static and dynamic gamma-axons. Sensitivity to small sinusoidal stretches superimposed on triangles was enhanced during triangular lengthening but not during shortening. These af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90289-x
更新日期：1982-01-28 00:00:00
abstract：:In this study, seizures in the dentate gyrus were triggered by 2 Hz electrical stimulation while, at the same time, serial changes in paired-pulse depression was measured in free-moving rats. The perforant path was stimulated by paired pulses 25 ms apart and recordings were made in the dentate gyrus. We also observed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01118-9
更新日期：1997-11-21 00:00:00
abstract：:Glycogen synthase kinase (GSK)-3beta and extracellular signal-regulated kinase (ERK) regulate several cellular signaling pathways in common, including embryonic development, cell differentiation and apoptosis. In this study, we investigated whether GSK-3beta inhibition is involved in ERK activation, which affects the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.018
更新日期：2007-12-01 00:00:00
abstract：:Decision making is commonly conceived to reflect the interplay of mutually antagonistic systems: executive processes must inhibit affective information to make adaptive choices. Consistent with this interpretation, prior studies have shown that the dorsolateral prefrontal cortex (dlPFC) is activated by executive proce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.026
更新日期：2011-06-13 00:00:00
abstract：:The neurotrophic effect of bFGF on dopamine (DA) neurons in vitro depends upon its mitogenic activity on glial cells. We examined whether glial secretion of the dopaminergic growth factor GDNF is responsible for the trophic activity of bFGF on mesencephalic DA neurons. When added with lower concentrations of bFGF, GDN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00311-3
更新日期：1996-06-10 00:00:00
abstract：:Some afferent fibers from the pudendal nerve of the female cat were stimulated by pressing on the perineal skin, the vagina or the uterine cervix. Three different types of skin mechanoreceptors were found: (1) with low threshold (< 20 mg) and slow-adapting discharges; (2) with high threshold (0.1-0.5 g) and slow-adapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91589-x
更新日期：1994-08-29 00:00:00
abstract：:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01318-c
更新日期：1995-02-13 00:00:00
abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90274-9
更新日期：1984-12-03 00:00:00
abstract：:Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:Our previous studies have demonstrated that a mixture of bovine brain gangliosides ( BBG ) applied to Neuro-2a neuroblastoma cells markedly increased the degree and rate of neurite formation. In the present study, the cytoskeletal basis for BBG -mediated neurite outgrowth was investigated by comparing cells grown in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90075-0
更新日期：1984-03-01 00:00:00
abstract：:The present study evaluated whether environmental enrichment-related effects on the development of stereotyped behavior in deer mice were associated with alterations in neuronal metabolic activity. Deer mice were reared under either enriched or standard housing conditions for 60 days following weaning. All mice were t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02472-1
更新日期：2002-05-31 00:00:00
abstract：:Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.062
更新日期：2008-01-29 00:00:00
abstract：:Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90480-7
更新日期：1981-05-18 00:00:00
abstract：:Two experiments were undertaken to investigate dopaminergic involvement in the local rate of responding on a fixed ratio 5 (FR5) instrumental lever pressing schedule. Rats were trained to press a lever for food reinforcement on a FR5 schedule, and a computer program was used to record the interresponse time (IRT) for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90958-p
更新日期：1993-11-19 00:00:00
abstract：:We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00258-8
更新日期：1997-06-13 00:00:00
abstract：:Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90471-6
更新日期：1976-01-23 00:00:00
