Abstract：
:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in the shock-probe burying test. In contrast, infusions into the central nucleus impaired shock-probe avoidance, but did not impair open-arm avoidance. Both of these site-specific, midazolam-induced anxiolytic effects were blocked by a pre-infusion of the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil). None of the treatments affected defensive burying. These results suggest that benzodiazepine receptors in the central and basolateral amygdaloid nuclei differentially mediate the anti-anxiety effects of benzodiazepine anxiolytics.
journal_name
Brain Resjournal_title
Brain researchauthors
Pesold C,Treit Ddoi
10.1016/0006-8993(94)01318-csubject
Has Abstractpub_date
1995-02-13 00:00:00pages
213-21issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)01318-Cjournal_volume
671pub_type
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