Progesterone enhances L-dopa-stimulated dopamine release from the caudate nucleus of freely behaving ovariectomized-estrogen-primed rats.


:In the present experiment we examined the effect of progesterone upon dopamine (DA) release induced by a direct infusion of unlabeled L-dihydroxyphenylalanine (L-DOPA) into the caudate nucleus of freely behaving rats. Ovariectomized rats were implanted with a push-pull cannula directed at the caudate nucleus and subjected to perfusion under 3 different hormonal conditions: (1) following 4 days of treatment with estradiol benzoate (EB), (2) following 4 days of treatment with estradiol benzoate plus progesterone at 4-6 h prior to perfusion (EB + P-4-6 h) and (3) following 4 days of treatment with estradiol benzoate plus progesterone at 28 h prior to perfusion (EB + P-28 h). During each perfusion session and under each of the 3 hormonal treatment conditions, L-DOPA was infused through the push side of the cannula. Three increasing doses of L-DOPA (10(-6), 10(-5) and 10(-4) M) were infused with a 45-75 min interval between infusions. Regardless of hormonal treatment condition, a clear dose-response increase in DA and 3,4-dihydroxyphenylacetic acid (DOPAC), but not 5-HIAA, output was observed in response to the increasing doses of L-DOPA infusion. For each of the 3 doses of L-DOPA, maximal DA output was observed for animals tested under the EB + P-4-6 h hormonal condition, with statistically significant differences in the areas under the L-DOPA-stimulated DA response curves obtained following the 10(-6) and 10(-5) M doses of L-DOPA infusion.(ABSTRACT TRUNCATED AT 250 WORDS)


Brain Res


Brain research


Dluzen DE,Ramirez VD




Has Abstract


1989-08-07 00:00:00














  • The influx of Ca2+ and the release of noradrenaline evoked by the stimulation of presynaptic nicotinic receptors of chick sympathetic neurons in culture are not mediated via L-, N-, or P-type calcium channels.

    abstract::We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dolezal V,Lee K,Schobert A,Hertting G

    更新日期:1996-11-18 00:00:00

  • Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input.

    abstract::Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that regulate innervating sympathetic neurons. Here, we used western blot analysis to investigate changes in NGF and NT-3 protein in several peripheral tissues following loss of sympathetic input. Following removal of the superior cervical...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Randolph CL,Bierl MA,Isaacson LG

    更新日期:2007-05-04 00:00:00

  • A LANT6-like substance that is distinct from neuromedin N is present in pallidal and striatal neurons in monkeys.

    abstract::The basal ganglia of rhesus and squirrel monkeys were examined using immunohistochemical techniques with antibodies against the neurotensin-related hexapeptides Lys8-Asn9-Neurotensin(8-13) (LANT6) and Neuromedin N. A high percentage of neurons in both segments of globus pallidus and many large neurons of the striatum ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Reiner A

    更新日期:1987-09-29 00:00:00

  • ATP-induced synaptic potentiation in hippocampal slices.

    abstract::The purpose of this study was to investigate the influence of different adenosine triphosphate (ATP) concentrations (ranging from 400 nM to 250 microM) on hippocampal potentials recorded from pyramidal neurons. ATP applied at a concentration of 400 nM induced a 100% increase in the size of the population spike (potent...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wieraszko A,Seyfried TN

    更新日期:1989-07-10 00:00:00

  • Ontogenesis of muscarinic receptors in cultured rat hippocampal cells.

    abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fernandez-Tomé P,Segal M

    更新日期:1987-09-01 00:00:00

  • Localization of cholecystokinin-octapeptide-like-immunoreactivity in neurons cultured from rat cerebral cortex.

    abstract::Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Delfs JR,Zhu CH,Dichter MA

    更新日期:1984-02-13 00:00:00

  • Cerebral microvascular responses to endothelins: the role of ETA receptors.

    abstract::The regulatory role of endothelins in cerebral microvessels was investigated in a recently developed model system which allows the study of small cerebral vessels in their normal microenvironment. Using brain slices of the rat neocortex, it was shown that the isopeptide endothelin-3 (ET-3) had no effect on cerebral mi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sagher O,Jin Y,Thai QA,Fergus A,Kassell NF,Lee KS

    更新日期:1994-09-26 00:00:00

  • Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges.

    abstract::The ability of embryonic hippocampal tissue to promote regeneration of cholinergic axons in the septohippocampal system has been studied in adult rats. Strips of embryonic hippocampus, taken from 7-40 mm rat fetuses, were implanted into a 2-3 mm wide cavity which completely transected the septal cholinergic axons inne...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kromer LF,Björklund A,Stenevi U

    更新日期:1981-04-06 00:00:00

  • Differential effects of the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of the excitatory amino acids system on LH and FSH secretion. Its effects on the hypothalamic luteinizing hormone releasing hormone during maturation in male rats.

    abstract::The present experiments describe the effect of NMDA and kainate agonists of the NMDA and non-NMDA subtype of receptors respectively of the excitatory amino acids (EAAs) system in prepubertal (16 days of age) and peripubertal (30-day-old rats) male rats on the in vitro hypothalamic release of GnRH, and on the in vivo L...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Carbone S,Szwarcfarb B,Rondina D,Feleder C,Moguilevsky JA

    更新日期:1996-01-29 00:00:00

  • The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus.

    abstract::The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hentall ID,Budhrani VM

    更新日期:1990-07-09 00:00:00

  • Potassium and calcium channel dependence of bursting in cultured neuronal networks.

    abstract::Increases in extracellular potassium concentrations reliably increase burst rates in cultured fetal murine spinal cord networks. This effect could be mimicked by either blocking voltage-gated potassium conductances or facilitating excitatory synaptic interactions, but not by blocking specific calcium-dependent potassi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rhoades BK,Gross GW

    更新日期:1994-04-18 00:00:00

  • Direct in vivo comparison of two mechanisms releasing dopamine in the rat striatum.

    abstract::A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Olivier V,Guibert B,Leviel V

    更新日期:1995-10-09 00:00:00

  • Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.

    abstract::Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

    更新日期:2003-05-30 00:00:00

  • The reflex responses of single motor units in human lower lip muscles to mechanical stimulation.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: McClean MD,Smith A

    更新日期:1982-11-11 00:00:00

  • Intraventricular administration of a FIV-envelope protein induces sleep architecture changes in rats.

    abstract::Fifteen adult male Sprague-Dawley rats were implanted with a set of electrodes for standard sleep recordings. A stainless steel cannula was also implanted into the lateral ventricle of these rats. Fifteen additional rats were implanted with a cannula alone. Rats with electrodes were habituated for 3 days or more to th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Prospéro-García O,Herold N,Waters AK,Phillips TR,Elder JH,Henriksen SJ

    更新日期:1994-10-03 00:00:00

  • Hippocampal responses evoked by tooth pulp and acoustic stimulation: depth profiles and effect of behavior.

    abstract::Averaged evoked potentials and unitary discharges in response to tooth pulp and acoustic click stimuli were recorded from the hippocampus of freely moving rats. The spatial distribution of evoked field responses to tooth pulp stimulation and acoustic clicks were identical. Averaged evoked potentials consisted of a lar...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brankack J,Buzsáki G

    更新日期:1986-07-23 00:00:00

  • Pattern of fos activation in the ventral tegmental area (VTA) of male prairie vole's (Microtus ochrogaster) in response to infant-related stimuli.

    abstract::Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lang DY,Bamshad M,Dorcely R

    更新日期:2019-07-01 00:00:00

  • Monosodium glutamate: increased neurotoxicity after removal of neuronal re-uptake sites.

    abstract::Microinjections of monosodium glutamate (MSG; 300 microgram/0.5 microliter) into the hippocampus of the adult rat result in only marginal damage to local neurons. Perforant path transections, removing glutamatergic afferents to hippocampal granule cells, make the latter markedly more vulnerable to a subsequent MSG inj...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Köhler C,Schwarcz R

    更新日期:1981-05-04 00:00:00

  • The effects of GABA and benzodiazepines on neurones in the suprachiasmatic nucleus (SCN) of Syrian hamsters.

    abstract::Administration of benzodiazepines at appropriate times in the circadian cycle induce phase-shifts in circadian locomotor activity. The possibility that benzodiazepine-induced shifts are mediated at the level of the suprachiasmatic nuclei (SCN), identified as the circadian pacemaker in mammals, was examined electrophys...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mason R,Biello SM,Harrington ME

    更新日期:1991-06-21 00:00:00

  • Quantitative morphological analysis of spinal motoneurons.

    abstract::Horseradish peroxidase was injected intracellularly into motoneurons responding to cutaneous stimulation of the central foot pad of the hind limb in cats. Three motoneurons were selected for detailed analysis: two excited by foot pad stimulation, and one postsynaptically inhibited by such stimulation. The overall leng...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Egger MD,Egger LD

    更新日期:1982-12-16 00:00:00

  • Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination.

    abstract::In order to examine the relationship between myelination and sensitivity to anoxia in adult white matter, we studied action potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating lesions had been produced using ethidium bromide/X-irradiation. Acutely isolated spinal cords from...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Imaizumi T,Kocsis JD,Waxman SG

    更新日期:1998-01-01 00:00:00

  • Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry.

    abstract::The actions of dopamine are mediated by 5 or more receptor subtypes, any of which may be coupled by G-proteins to adenylate cyclase (D1-family: stimulatory, D2-family: inhibitory or no action). Postnatal ocular growth in the chick is a vision-dependent mechanism which involves D2-type receptors in either the retina or...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rohrer B,Stell WK

    更新日期:1995-10-16 00:00:00

  • Involvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells.

    abstract::Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

    更新日期:2015-05-22 00:00:00

  • NAD(P)H oxidase in paraventricular nucleus contributes to the effect of angiotensin II on cardiac sympathetic afferent reflex.

    abstract::We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang Y,Yu Y,Zhang F,Zhong MK,Shi Z,Gao XY,Wang W,Zhu GQ

    更新日期:2006-04-12 00:00:00

  • Restoration of rhythmic slow activity (theta) in the subcortically denervated hippocampus by fetal CNS transplants.

    abstract::Solid pieces of the fetal septal region (SG) or hippocampus (HPC) were implanted in a cavity formed by aspiration of the fimbria fornix (FF) and the overlying cingulate cortex on one side in adult rats. In other lesioned animals cell suspensions obtained from the fetal septal area (SS) or the locus coeruleus region of...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Buzsáki G,Gage FH,Czopf J,Björklund A

    更新日期:1987-01-06 00:00:00

  • Chronoamperometry in brain slices: quantitative evaluations of in vivo electrochemistry.

    abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schenk JO,Miller E,Rice ME,Adams RN

    更新日期:1983-10-24 00:00:00

  • Long-lasting inhibition of the human soleus H reflex pathway after passive movement.

    abstract::Human soleus H reflexes are attenuated during passive pedalling movements. This depression occurs within 70 ms of movement onset. We hypothesized that the reflex gain would return to control values with a similar brevity following movement. However, H reflexes sampled following a slow (10 rpm) passive pedalling moveme...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章


    authors: Misiaszek JE,Brooke JD,Lafferty KB,Cheng J,Staines WR

    更新日期:1995-04-17 00:00:00

  • Evidence for a glycinergic pathway connecting the two cochlear nuclei: an immunocytochemical and retrograde transport study.

    abstract::A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wenthold RJ

    更新日期:1987-07-07 00:00:00

  • Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.

    abstract::Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against beta-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of beta-amyloid peptide (betaAP(25-35)) and toxicity was assessed after...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Caraci F,Chisari M,Frasca G,Canonico PL,Battaglia A,Calafiore M,Battaglia G,Bosco P,Nicoletti F,Copani A,Sortino MA

    更新日期:2005-06-14 00:00:00

  • Quantitation and morphological characterization of rapid axon and dendritic growth from single cerebral hemispheric neurons in hydrated collagen lattice culture.

    abstract::Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Coates PW

    更新日期:1986-02-01 00:00:00