Abstract：
:In the present experiment we examined the effect of progesterone upon dopamine (DA) release induced by a direct infusion of unlabeled L-dihydroxyphenylalanine (L-DOPA) into the caudate nucleus of freely behaving rats. Ovariectomized rats were implanted with a push-pull cannula directed at the caudate nucleus and subjected to perfusion under 3 different hormonal conditions: (1) following 4 days of treatment with estradiol benzoate (EB), (2) following 4 days of treatment with estradiol benzoate plus progesterone at 4-6 h prior to perfusion (EB + P-4-6 h) and (3) following 4 days of treatment with estradiol benzoate plus progesterone at 28 h prior to perfusion (EB + P-28 h). During each perfusion session and under each of the 3 hormonal treatment conditions, L-DOPA was infused through the push side of the cannula. Three increasing doses of L-DOPA (10(-6), 10(-5) and 10(-4) M) were infused with a 45-75 min interval between infusions. Regardless of hormonal treatment condition, a clear dose-response increase in DA and 3,4-dihydroxyphenylacetic acid (DOPAC), but not 5-HIAA, output was observed in response to the increasing doses of L-DOPA infusion. For each of the 3 doses of L-DOPA, maximal DA output was observed for animals tested under the EB + P-4-6 h hormonal condition, with statistically significant differences in the areas under the L-DOPA-stimulated DA response curves obtained following the 10(-6) and 10(-5) M doses of L-DOPA infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Dluzen DE,Ramirez VDdoi
10.1016/0006-8993(89)90150-9subject
Has Abstractpub_date
1989-08-07 00:00:00pages
122-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90150-9journal_volume
494pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glycine is thought to be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly stained with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90590-r
更新日期：1991-04-26 00:00:00
abstract：:The present study examined the effects of excitotoxins which activate distinct excitatory amino acid (EAA) receptor subtypes on the levels of Methionine-enkephalin-like immunoreactivity (ME-i.r.) in the striatum and globus pallidus, with a view to developing a model of the striatopallidal enkephalin deficit that preva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90029-b
更新日期：1990-12-17 00:00:00
abstract：:The effect of microinfusions of cholecystokinin octapeptide (CCK8) and its antagonist L364,718 on duodenal and jejunal motility were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the duodeno-jejunal wall. Steel cannulas were placed bilaterally in ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91124-y
更新日期：1990-01-29 00:00:00
abstract：:The effect of electrolytic lesion of the paraventricular nucleus of the hypothalamus (PVN) on yawning and penile erection induced by apomorphine, oxytocin and adrenocorticotropic hormone (ACTH1-24) was studied in male rats. In sham-operated rats, apomorphine (50 micrograms/kg s.c.), oxytocin (30 ng i.c.v.), and ACTH1-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91305-9
更新日期：1987-09-22 00:00:00
abstract：:Male rats were dehydrated for 22 h and then given 4 h intracerebroventricular (i.c.v.) infusions which commenced 2 h prior to the beginning of a 2-h fluid access period. I.c.v. infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access per...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91437-5
更新日期：1987-05-26 00:00:00
abstract：:Using a well-established model of binge-like ethanol treatment of rat pups on postnatal days (PD) 4-9, we found that maturation of GABAA receptor (GABAAR) miniature postsynaptic currents (mPSCs) was substantially blunted for medial septum/diagonal band (MS/DB) neurons in brain slices on PD 11-16. Ethanol reduced mPSC ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.054
更新日期：2013-07-03 00:00:00
abstract：:Neuropeptide Y (NPY) presynaptically inhibits excitatory transmission in area CA1 of rat hippocampus. As postsynaptic NPY receptors in certain other tissues have been shown to be coupled to G-proteins, we have tested the hypothesis that the hippocampal NPY effects are also mediated by G-proteins. Pretreatment of rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90403-4
更新日期：1989-09-25 00:00:00
abstract：:Neuropeptide- and serotonin-like immunoreactivities were studied in the lumbar spinal cord of the cat after a longitudinal incision in the ventral funiculus. This lesion, which accomplishes a central axotomy of motoneurons, was accompanied by increased level of Met-enkephalin-like immunoreactivity in nerve endings in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90157-7
更新日期：1990-11-26 00:00:00
abstract：:Cultured cells derived from Tay-Sachs disease (TSD) fetal cerebellum were shown to accumulate GM2 ganglioside when compared with control cultures. In contrast, fibroblasts derived from TSD fetal lung do not contain GM2. GM2 was identified by thin-layer chromatography (TLC) and confirmed by gas-liquid chromatography (G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91052-0
更新日期：1976-07-23 00:00:00
abstract：:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03192-9
更新日期：2001-02-02 00:00:00
abstract：BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02769-4
更新日期：2000-11-03 00:00:00
abstract：:The possibility has been mentioned that a change in the structure is responsible for the deviant behavioral activity of gamma-endorphin in extracts of postmortem brain and pituitary gland samples of schizophrenic patients. This paper describes the investigation of this possibility by means of: amino acid composition a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90896-6
更新日期：1986-06-18 00:00:00
abstract：:The heterogeneous nature of vesicles has been studied by evaluating exocytotic events released from the cell body of a dopamine-containing neuron of Planorbis corneus. Vesicular exocytosis has been elicited by stimulation with in situ application of elevated potassium and has been monitored electrochemically with a ca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00989-9
更新日期：1995-12-01 00:00:00
abstract：:The turning effects of the unilateral intranigral injection of morphine and of different analogs of dynorphin and enkephalin were studied. All injections were made in awake rats through cronically implanted guide cannulae. Dynorphin1-13 at a dose of 10 micrograms (0.6 nmol) and dynorphin1-17 at a dose of 2 micrograms ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91074-1
更新日期：1985-08-26 00:00:00
abstract：:The bag cell neurons of Aplysia are capable of generating an afterdischarge, which, in vivo, triggers egg-laying behavior. Pharmacologic elevation of cyclic AMP levels in isolated bag cell neurons has been shown to initiate repetitive firming similar to that seen during an afterdischarge, and to decrease outward curre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91733-w
更新日期：1990-11-05 00:00:00
abstract：:The first phase of this study involves injecting a different fluorescent retrograde axonal tracer into the subthalamic nucleus, the substantia nigra, and the mesopontine tegmentum. Multiple labeled cells are found within the caudal third of the globus pallidus. The entopeduncular nucleus and adjacent basal forebrain s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90948-7
更新日期：1989-05-15 00:00:00
abstract：:Using a dual-serial-arithmetic paradigm, we examined whether a capacity limitation constrains the neural activation that underlies dual-task performance. Six conditions were run in the experiment (the baseline, single-addition, single-subtraction, dual-addition, dual-subtraction, and the dual-operation condition). In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.12.070
更新日期：2008-03-14 00:00:00
abstract：:The visual Wulst (VW) in the avian telencephalon is thought to be an avian equivalent of the mammalian striate cortex. Effects of electrical stimulation of VW were studied in the isthmo-optic nucleus (ION) of the Japanese quail by extracellular recording. Most ION neurons examined were activated by VW stimulation, and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90800-6
更新日期：1987-03-17 00:00:00
abstract：:DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90144-x
更新日期：1992-06-12 00:00:00
abstract：:Aging is accompanied by an impairment of associative memory. The medial temporal lobe and fronto-striatal network, both involved in associative memory, are known to decline functionally and structurally with age, leading to the so-called associative binding deficit and the resource deficit. Because the MTL and fronto-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.011
更新日期：2010-02-22 00:00:00
abstract：:An indirect method of immunocytochemistry showed that cholera toxin and its B-subunit served as specific neuronal surface markers in conjunction with monoclonal anti-cholera toxin and FITC labeled anti-mouse Fab. The cell types which get specifically stained in culture were peripheral neurons from dorsal root ganglion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90305-5
更新日期：1982-06-24 00:00:00
abstract：:Visual search is characterized as efficient (RT independent of distractor number) or inefficient (RT increasing with distractor number). Our goal was to determine if any brain regions are differentially activated by the attentional demands of these two search modes. We used fMRI to examine activation patterns during s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.004
更新日期：2012-09-26 00:00:00
abstract：:These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by meas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01211-5
更新日期：1997-01-02 00:00:00
abstract：:Vestibular nerve branches innervating the sensory epithelia of the three semicircular canals or of the three otolith organs of frogs were selectively labeled in-vitro with biocytin. Labeled afferent fibers from the semicircular canals, utricle, and lagena were encountered in each of the four vestibular nuclei and thei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03075-x
更新日期：2001-12-07 00:00:00
abstract：:Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/s0006-8993(99)01639-x
更新日期：1999-07-17 00:00:00
abstract：:The central type benzodiazepine receptor (BDZr), an allosteric modulatory site of the GABAA receptor-anion channel, has been shown in vitro to respond to drugs with positive efficacy (agonists), zero efficacy (competitive antagonists) and drugs with negative efficacy (inverse agonists). However, this general concept o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90131-e
更新日期：1991-08-23 00:00:00
abstract：:The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90452-0
更新日期：1988-12-06 00:00:00
abstract：:Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2020.146864
更新日期：2020-08-01 00:00:00
abstract：:Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00743-3
更新日期：1996-10-28 00:00:00
abstract：:We have investigated sensitivity to the conditioned fear procedure of mice is influenced by the genetic deletion of alpha2A adrenoceptors (ARs). We observed a heightened freezing response in the discrete cue memory test in alpha2A AR knockout (alpha2A AR KO) mice and in D79N mice, a transgenic mouse strain with functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03248-7
更新日期：2003-10-03 00:00:00
