Abstract：
:Neuropeptide Y (NPY) presynaptically inhibits excitatory transmission in area CA1 of rat hippocampus. As postsynaptic NPY receptors in certain other tissues have been shown to be coupled to G-proteins, we have tested the hypothesis that the hippocampal NPY effects are also mediated by G-proteins. Pretreatment of rats with pertussis toxin (PTX) was ineffective in blocking NPY's presynaptic inhibitory actions in area CA1 of the hippocampal slice. The presynaptic inhibitory action of baclofen was also unaffected by PTX pretreatment. However, in these same PTX-pretreated slices, the postsynaptic hyperpolarizing actions of baclofen and 5-hydroxytryptamine were blocked. We suggest that pre- and postsynaptic receptors possess different coupling mechanisms to their effectors.
journal_name
Brain Resjournal_title
Brain researchauthors
Colmers WF,Pittman QJdoi
10.1016/0006-8993(89)90403-4subject
Has Abstractpub_date
1989-09-25 00:00:00pages
99-104issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90403-4journal_volume
498pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.02.011
更新日期：2014-03-27 00:00:00
abstract：:The presence of an adrenergic projection from the nucleus of the tractus solitarius (NTS) to the parabrachial nucleus (PB) was demonstrated by the immunocytochemistry combined with a retrograde tracing method. Numerous neurons containing both phenylethanolamine N-methyltransferase, a marker for adrenaline, and wheat g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90654-3
更新日期：1988-09-06 00:00:00
abstract：:Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00056-x
更新日期：1996-05-06 00:00:00
abstract：:Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00501-5
更新日期：1997-07-18 00:00:00
abstract：:Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91232-x
更新日期：1982-06-03 00:00:00
abstract：:To determine the involvement of vasoactive intestinal polypeptide (VIP) in the development of kindling in rats, VIP or antibody to VIP (anti-VIP) was injected into the third ventricle after the daily stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling was sign...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91082-c
更新日期：1991-02-08 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:The activity of 294 single units was recorded from the dorsolateral prefrontal cortex of monkeys performing two visual discrimination tasks with delayed response. One task, delayed matching-to-sample (DMS), required memory of a colored cue for later (18 s) matching and choice of color; the cue did not connote the loca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90436-2
更新日期：1988-12-06 00:00:00
abstract：:Myelin deficiency (mld) is an autosomal recessive mutation in mice characterized by a severe myelin deficit in the central nervous system (CNS). The primary defect in mld is a reduction of the synthesis of the myelin basic protein (MBP) and probably lies in a regulatory element of the MBP gene. In young mld heterozygo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90045-3
更新日期：1987-12-01 00:00:00
abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90099-7
更新日期：1981-01-01 00:00:00
abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.066
更新日期：2008-03-04 00:00:00
abstract：:We measured soleus H-reflex in the Sprague-Dawley rat as a function of time of day. H-reflex amplitude displayed a marked diurnal variation, even though background EMG and M-response amplitude were stable through the day. The H-reflex was largest in the late morning and smallest around midnight. Thus, its rhythm was o...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1994-06-13 00:00:00
abstract：:The effects of a conditioning lesion on the rate of sudomotor axon regeneration were judged by the recovery of sweat gland (SG) secretion after cholinergic stimulation. Three groups of mice were given a conditioning lesion by crushing the sciatic nerve at mid-thigh 4, 7, and 14 days before a test lesion. A 4th group r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90547-o
更新日期：1990-02-19 00:00:00
abstract：:Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90195-x
更新日期：1982-08-01 00:00:00
abstract：:Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and hi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.053
更新日期：2005-02-09 00:00:00
abstract：:The distribution of alpha scorpion toxin (alpha-ScTx) receptors was examined in differentiated mouse neuroblastoma cell cultures (N IE 115 clone) by electron microscope autoradiography using [125I]alpha-ScTx. This neurotoxin binds specifically to voltage-sensitive sodium channels, slowing down the inactivation of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90561-x
更新日期：1985-05-13 00:00:00
abstract：:alpha-Motoneurons innervating the triceps surae and short plantar muscles were stained intracellularly with horseradish peroxidase (HRP) in 0-44-day-old kittens and adult cats. The terminal arborizations of the recurrent axon collaterals in the spinal cord were studied in the light microscope (LM). The short plantar m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90132-4
更新日期：1985-01-01 00:00:00
abstract：:The cellular origin and degree of collateralization of the subthalamostriatal, subthalamonigral and subthalamopallidal projections in the squirrel monkey (Saimiri sciureus) were studied using lectin-conjugated horseradish peroxidase (WGA-HRP), Nuclear yellow (NY) and Fast blue (FB) as retrograde tracers. In a first ex...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91674-x
更新日期：1987-12-15 00:00:00
abstract：:In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90161-4
更新日期：1975-12-26 00:00:00
abstract：:Hybridization histochemical and immunohistochemical methods were used to characterize the distribution of corticotropin-releasing factor (CRF) messenger RNA (mRNA) and peptide, respectively, in the central auditory system of the rat. Cell bodies expressing CRF mRNA and/or immunoreactivity (IR) were detected at each le...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90571-c
更新日期：1991-04-26 00:00:00
abstract：:Somatostatin-like immunoreactivity (Som-LI) and glycine high-affinity uptake have been characterized in the Rana pipiens retina. These labels are found in both the outer and inner plexiform layers (OPL and IPL), suggesting that interplexiform cells (IPCs) contain both Som and glycine in this retina. In double-label ex...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91215-8
更新日期：1989-08-21 00:00:00
abstract：:Protein kinase C (PKC) is a family of serine/threonine kinases comprised of 10 isoforms. Although commercial antibodies are available for all 10 isoforms, the specificity of these antibodies has been questioned. We have identified immunoblot conditions in which commercially purchased PKC antibodies are specific for th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.110
更新日期：2006-04-14 00:00:00
abstract：:We investigated the brain-stem pathway(s) by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the palate contralateral to the stimulated side. This occurs in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.010
更新日期：2004-09-10 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
abstract：:To test the hypothesis that there is a functional modulation of conventional EEG bands associated with preparatory attention, putative changes in the spontaneous brain rhythms and their associated cerebral sources were addressed. The goals of the present report were, first, to find the brain areas with maximal rhythmi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.019
更新日期：2006-08-30 00:00:00
abstract：:This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91292-9
更新日期：1988-04-12 00:00:00
abstract：:MabQ155, a monoclonal antibody against synaptophysin, has been used to conduct a light microscopic survey of synaptogenesis in the suprachiasmatic nucleus of the perinatal rat. Synaptophysin is an integral component of synaptic vesicle membranes which is expressed in growth cones and growth cone filopodia as well as i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90891-x
更新日期：1991-03-22 00:00:00
abstract：:Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01549-7
更新日期：1998-04-20 00:00:00
abstract：:We utilized proton magnetic resonance spectroscopy to evaluate the metabolic profile of the hippocampus and anterior cingulate cortex of the developing rat brain from postnatal days 14-70. Measured metabolite concentrations were modeled using linear, exponential, or logarithmic functions and the time point at which th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.09.028
更新日期：2016-11-15 00:00:00
