Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleus.

abstract：:To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neur...

journal_title：Brain research

authors： Scammell TE,Price KJ,Sagar SM

更新日期：1993-08-06 00:00:00

abstract：:Anterograde and retrograde tracing experiments employing WGA-HRP were used to identify an auditory projection area within the frontal telencephalon of the pigeon. The projection originates in a nucleus of the lateral lemniscus, travels with the quintofrontal tract and terminates within nucleus basalis. The location of...

journal_title：Brain research

authors： Arends JJ,Zeigler HP

更新日期：1986-11-29 00:00:00

abstract：:Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stai...

journal_title：Brain research

authors： Masukawa LM,O'Connor WM,Lynott J,Burdette LJ,Uruno K,McGonigle P,O'Connor MJ

更新日期：1995-04-24 00:00:00

abstract：:Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...

journal_title：Brain research

authors： Yang L,Liu X,Yao K,Sun Y,Jiang F,Yan H,Mao P,Fan S,Wei X,Liu Y,Yuan W,Zhang S

更新日期：2019-08-15 00:00:00

abstract：:Neurophysiological responses were recorded in individual fibers of the lingual and chorda tympani nerves and in single cortical neurons in the rat in response to a battery of tactile, thermal and chemical stimuli applied to the oral cavity. Two categories of thermally sensitive units were identified. Chorda tympani fi...

journal_title：Brain research

authors： Kosar E,Schwartz GJ

更新日期：1990-04-16 00:00:00

abstract：:Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins between cellular membranes, and androgen receptor (AR) mRNA are both increased in song control nuclei of juvenile males comp...

journal_title：Brain research

authors： Wu D,Tang YP,Wade J

更新日期：2010-07-09 00:00:00

abstract：:The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...

journal_title：Brain research

authors： Mikkelsen M,Harris AD,Edden RAE,Puts NAJ

更新日期：2018-12-15 00:00:00

abstract：:The rat mutant dystonic displays an autosomal recessive neurological disease characterized by slow, twisting movements of the limbs and trunk. Rats displaying clinical signs also show a decreased behavioral response to the dopaminergic blocker, haloperidol. Investigation of the development of the cataleptic response t...

journal_title：Brain research

authors： McKeon TW,Lorden JF,Oltmans GA,Beales M,Walkley SU

更新日期：1984-08-06 00:00:00

abstract：:Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentati...

journal_title：Brain research

authors： Fukuda N,Naito S,Masukawa D,Kaneda M,Miyamoto H,Abe T,Yamashita Y,Endo I,Nakamura F,Goshima Y

更新日期：2015-03-30 00:00:00

abstract：:Odor stimulation of the nose in the box turtle and the gopher tortoise produced a characteristic series of slow potentials in the olfactory bulb which were referred to as the odor evoked response. When recorded with direct coupling, the odor evoked response had 3 components: wave I, a short duration monophasic event; ...

journal_title：Brain research

authors： Beuerman RW

更新日期：1975-10-24 00:00:00

abstract：:Murine urocortin 3 (mUcn 3), a member of the corticotropin releasing factor (CRF) peptide family, was recently identified. Of known agonists, this neuropeptide displays the highest degree of selectivity in binding to the CRF(2) receptor. These experiments sought to test the hypothesis that CRF(2) receptors have a role...

journal_title：Brain research

authors： Valdez GR,Zorrilla EP,Rivier J,Vale WW,Koob GF

更新日期：2003-08-08 00:00:00

abstract：:The objective was to obtain detailed topographic determinations of cytochrome oxidase activity in the gerbil central auditory system at the light microscopic level. Quantitative techniques were developed using (1) tissue standards calibrated to express histochemical measures as actual enzyme activity units, (2) densit...

journal_title：Brain research

authors： Gonzalez-Lima F,Jones D

更新日期：1994-10-10 00:00:00

abstract：OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...

journal_title：Brain research

authors： Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

更新日期：2021-01-01 00:00:00

abstract：:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...

journal_title：Brain research

authors： Iordanova MD,Haralambous T,McNally GP,Westbrook RF

更新日期：2013-06-23 00:00:00

abstract：:To determine whether the paraventricular nucleus (PVN) contributes to the development of hypertension in spontaneously hypertensive rats (SHR), we compared cardiovascular responses to ganglionic blockade with hexamethonium or vasopressin antagonism with dPVAVP in sham-operated or PVN lesioned SHR and Wistar-Kyoto rats...

journal_title：Brain research

authors： Takeda K,Nakata T,Takesako T,Itoh H,Hirata M,Kawasaki S,Hayashi J,Oguro M,Sasaki S,Nakagawa M

更新日期：1991-03-15 00:00:00

abstract：:L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...

journal_title：Brain research

authors： Wolf WA,Kuhn DM

更新日期：1984-03-19 00:00:00

abstract：:Rats were trained on a radial maze and then given electrolytic lesions of the MS followed by a single intraseptal injection of 5 micrograms of NGF. Three days later they were re-tested on the maze. They were also post-operatively tested for hyperemotionality. MS lesions severely impaired performance on the radial maze...

journal_title：Brain research

authors： Janis LS,Glasier MM,Martin G,Stackman RW,Walsh TJ,Stein DG

更新日期：1995-05-08 00:00:00

abstract：:The effects of forced swimming for 30 min on extracellular 5-hydroxytryptamine (5-HT) levels were examined in five brain regions in rats using in vivo microdialysis. A single dialysis probe was implanted under surgical anesthesia into either the striatum, ventral hippocampus, frontal cortex, amygdala, or lateral septu...

journal_title：Brain research

authors： Kirby LG,Allen AR,Lucki I

更新日期：1995-06-05 00:00:00

abstract：:Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...

journal_title：Brain research

authors： Vera PL,Nadelhaft I

更新日期：2001-05-18 00:00:00

abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...

journal_title：Brain research

authors： Pollack AE,Haisley EC

更新日期：2001-04-06 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding in the presence of compounds selective for ionotropic glutamate rece...

journal_title：Brain research

authors： Testa CM,Hollingsworth ZR,Shinozaki H,Penney JB Jr,Young AB

更新日期：1997-10-31 00:00:00

abstract：:By application of the anterograde transport technique of Phaseolus vulgaris leuco-agglutinin the descending autonomic projection of the paraventricular hypothalamic nucleus was investigated. The Phaseolus lectin technique allowed the detection of the cells of origin in the paraventricular PVN, the precise position of ...

journal_title：Brain research

authors： Luiten PG,ter Horst GJ,Karst H,Steffens AB

更新日期：1985-03-11 00:00:00

abstract：:The objective of this study was to determine if a prefrontal somatosensory mismatch response (sMMR) could be recorded in response to deviations in duration of somatosensory stimuli. Intracranial somatosensory event-related potentials were recorded from temporal, parietal, and frontal lobe sites in 12 pediatric patient...

journal_title：Brain research

authors： Spackman LA,Towell A,Boyd SG

更新日期：2010-01-15 00:00:00

abstract：:An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon or...

journal_title：Brain research

authors： Scott JJ,Davies P,Petit J

更新日期：1995-10-30 00:00:00

abstract：:The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...

journal_title：Brain research

authors： Besheer J,Schroeder JP,Stevenson RA,Hodge CW

更新日期：2008-09-26 00:00:00

abstract：:A direct projection from rat mesencephalic trigeminal nucleus (Vme) neurons to the hypoglossal nucleus (XII) motoneurons was studied using a double labeling method of anterogradely biotinylated dextran amine (BDA) tracing combined with retrogradely horseradish peroxidase (HRP) transport at both light and electron micr...

journal_title：Brain research

authors： Zhang J,Luo P,Pendlebury WW

更新日期：2001-10-26 00:00:00

abstract：:Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditio...

journal_title：Brain research

authors： Lee M,Suk K,Kang Y,McGeer E,McGeer PL

更新日期：2011-07-11 00:00:00

abstract：:Tyrosine hydroxylase immunohistochemical examination of the mesencephalon of severely parkinsonian MPTP-treated macaque fascicularis monkeys revealed a marked loss of substantia nigra pars compacta (SNc) neurons in both medial and central portions of the nucleus with a relative sparing of neurons in the dorsal-most po...

journal_title：Brain research

authors： Schneider JS,Yuwiler A,Markham CH

更新日期：1987-05-12 00:00:00

abstract：:Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induc...

journal_title：Brain research

authors： Yu A,Yang J,Pawlyk AC,Tejani-Butt SM

更新日期：1995-08-07 00:00:00

abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...

journal_title：Brain research

authors： Ennis SR,Novotny A,Xiang J,Shakui P,Masada T,Stummer W,Smith DE,Keep RF

更新日期：2003-01-10 00:00:00