Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons.

abstract：:Experiments were carried out on UC-11MG human astrocytoma cells, a continuous cell line that expresses a broad range of the biochemical and electrophysiological properties found in well-differentiated astrocytes. Because of a number of recent reports that astrocytes may express receptors for a variety of neuro-active ...

journal_title：Brain research

authors： Lucherini MJ,Gruenstein E

更新日期：1992-10-02 00:00:00

abstract：:Labyrinthine-intact guinea pigs received unilateral, brainstem cannula injections of (1) 2.5 micrograms of the selective dihydropyridine L-type Ca2+ channel agonist, Bay K 8644 (n = 4 animals); (2) 10 micrograms Bay K 8644 (n = 4); 12.5 micrograms of the selective dihydropyridine L-type Ca2+ channel antagonist, nifedi...

journal_title：Brain research

authors： Sansom AJ,Smith PF,Darlington CL

更新日期：1993-12-10 00:00:00

abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...

journal_title：Brain research

authors： Carroll PT

更新日期：1997-04-04 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...

journal_title：Brain research

authors： Gao H,Han Z,Bai R,Huang S,Ge X,Chen F,Lei P

更新日期：2017-02-15 00:00:00

abstract：:The effect of maternal hyperthermia on the developmental state of newborn guinea pig brains has been studied. Mean litter size and mean body weights of young from control and experimental mothers did not differ. Mean brain weight of young from control mothers (2.72 +/- 0.02 g) was larger than that from experimental mo...

journal_title：Brain research

authors： Hutchinson R,Bowler K

更新日期：1984-06-01 00:00:00

abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...

journal_title：Brain research

authors： She Y,Xu J,Duan Y,Su N,Sun Y,Cao X,Lao L,Zhang R,Xu S

更新日期：2015-12-10 00:00:00

abstract：:Human neuroblastoma SH-SY5Y cells were used to study the effects of transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2) on neuronal differentiation and acquisition of a catecholaminergic phenotype. SH-SY5Y cells express the intracellular factors activated through the receptors of the ...

journal_title：Brain research

authors： Gómez-Santos C,Ambrosio S,Ventura F,Ferrer I,Reiriz J

更新日期：2002-12-20 00:00:00

abstract：:Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, ...

journal_title：Brain research

authors： Romer SH,Dominguez KM,Gelpi MW,Deardorff AS,Tracy RC,Fyffe RE

更新日期：2014-02-14 00:00:00

abstract：:Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on the environmental temperature. Here, we evaluate whether a cold environment (4 degrees C) or drugs which chloride and glutamate ion channel function block METH neurotoxicity in mice. Adult male CD mice received METH i.p. (4 x 10 mg/...

journal_title：Brain research

authors： Ali SF,Newport GD,Holson RR,Slikker W Jr,Bowyer JF

更新日期：1994-09-26 00:00:00

abstract：:We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...

journal_title：Brain research

authors： Cohen AH,Baker MT,Dobrov TA

更新日期：1989-09-04 00:00:00

abstract：:These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...

journal_title：Brain research

authors： Quirarte GL,Galvez R,Roozendaal B,McGaugh JL

更新日期：1998-10-19 00:00:00

abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...

journal_title：Brain research

authors： Cohen I,Van der Kloot W

更新日期：1982-06-10 00:00:00

abstract：:Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...

journal_title：Brain research

authors： Bisagno V,Ferguson D,Luine VN

更新日期：2002-06-14 00:00:00

abstract：:The thalamic midline/intralaminar complex is part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways. The midline thalamic nuclei connect with the medial prefrontal cortex and the medial temporal lobe. On the other hand, the intralaminar nuc...

journal_title：Brain research

authors： Silva Ade M,de Santana MA,Morais PL,de Sousa TB,Engelberth RC,Lucena EE,Campêlo CL,Cavalcante JS,Cavalcante JC,Costa MS,do Nascimento ES Jr

更新日期：2014-10-24 00:00:00

abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

journal_title：Brain research

authors： Read SJ,Parsons AA

更新日期：2000-07-07 00:00:00

abstract：:SBA and NADPH-d histochemistries allow identification of functionally distinct components of the amphibian primary olfactory system. In Pipa, a secondarily aquatic frog, combination of both methodologies, using alternate sets of histological sections, reveals that, apart from Jacobson's organ, this species has a "wate...

journal_title：Brain research

authors： Meyer DL,Fackler IR,Jadhao AG,D'Aniello B,Kicliter E

更新日期：1997-07-11 00:00:00

abstract：:The participation of amygdaloid and striatal structures in the various signs of morphine withdrawal syndrome (MWS) has been investigated using two complementary approaches: intracerebral application of naloxone in various nuclei of dependent rats and effects of various lesions and transections on systemically induced ...

journal_title：Brain research

authors： Calvino B,Lagowska J,Ben-Ari Y

更新日期：1979-11-09 00:00:00

abstract：:Arginase-1, a marker for M2 phenotype alternatively activated macrophages, inhibits inflammation and is associated with phagocytosis of cell debris and apoptotic cells. We analyzed the expression of arginase-1, a competitive enzyme of inducible nitric oxide synthase (iNOS), in the spinal cords of Lewis rats with exper...

journal_title：Brain research

authors： Ahn M,Yang W,Kim H,Jin JK,Moon C,Shin T

更新日期：2012-05-09 00:00:00

abstract：:To identify the subtype of dopamine receptors critically involved in the rewarding effect of brain stimulation, four dopamine antagonists were intracranially injected in 25 rats. The importance of dopamine D1 receptors had been demonstrated previously by using SCH 23390, a highly selective D1 antagonist. Rats were imp...

journal_title：Brain research

authors： Nakajima S,Patterson RL

更新日期：1997-06-20 00:00:00

abstract：:We have previously shown that systemic administration of ondansetron, a selective serotonin type-3 (5-HT3) receptor antagonist, attenuates cholecystokinin (CCK)-induced suppression of food intake. The exact location of 5-HT3 receptors mediating this action is not clear and may involve hindbrain 5-HT3 receptors. In thi...

journal_title：Brain research

authors： Hayes MR,Covasa M

更新日期：2006-08-04 00:00:00

abstract：:The effects of 0.1 to 500 mM ethanol on NMDA-activated currents were studied in primary cultures of mouse cortical and hippocampal neurons. In whole-cell recordings the IC50S for inhibition of NMDA-activated currents by ethanol were 129 mM +/- 20 mM in hippocampal neurons and 126 +/- 18 mM in cortical neurons. In sing...

journal_title：Brain research

authors： Wright JM,Peoples RW,Weight FF

更新日期：1996-11-04 00:00:00

abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

journal_title：Brain research

authors： Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

更新日期：1999-11-20 00:00:00

abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...

journal_title：Brain research

authors： González-Mariscal G,García Dalmán C,Jiménez A

更新日期：2015-05-22 00:00:00

abstract：:The measurements of the ion conductances in molluscan somata, published by Connor and Stevens (1971), were converted into Hodgkin-Huxley like equations. The accuracy of these equations was shown with simulations. An advantage of these equations, compared to the original equations for the fast outward K+(A)-conductance...

journal_title：Brain research

authors： De Schutter E

更新日期：1986-09-10 00:00:00

abstract：:The responsiveness of the tonically firing single motor units (SMU) to Ia afferent volleys elicited by either mechanical (T-reflex) or electrical nerve stimulation (H-reflex) was tested in the extensor carpi radialis muscle (ECR) while the subjects were maintaining a steady wrist extension force using visual feedback ...

journal_title：Brain research

authors： Nafati G,Rossi-Durand C,Schmied A

更新日期：2004-08-27 00:00:00

abstract：:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...

journal_title：Brain research

authors： Hauss-Wegrzyniak B,Willard LB,Del Soldato P,Pepeu G,Wenk GL

更新日期：1999-01-02 00:00:00

abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...

journal_title：Brain research

authors： Friedrich VL Jr,Mugnaini E

更新日期：1983-09-12 00:00:00

abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...

journal_title：Brain research

authors： Vann RE,Rosecrans JA,James JR,Philibin SD,Robinson SE

更新日期：2006-10-30 00:00:00

abstract：:The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus...

journal_title：Brain research

authors： LaVail JH,Koo EH,Dekker NP

更新日期：1987-02-24 00:00:00

abstract：:Using nerve growth factor (NGF), anti-NGF sera and dissociated neonatal mouse dorsal root ganglionic neurons we present a microculture assay methodology for (1) the titration of neurotrophic factor (NTF) activity in monolayer culture, (2) the titration of NTF antibodies which 'block' NTF biological activity, (3) the t...

journal_title：Brain research

authors： Manthorpe M,Skaper SD,Varon S

更新日期：1981-12-28 00:00:00