Abstract：
:Experiments were carried out on UC-11MG human astrocytoma cells, a continuous cell line that expresses a broad range of the biochemical and electrophysiological properties found in well-differentiated astrocytes. Because of a number of recent reports that astrocytes may express receptors for a variety of neuro-active substances, we measured the effects of 12 different neurotransmitters on intracellular free Ca2+ (Ca2+i) in UC-11MG cells. Of these neurotransmitters only histamine was found to have a significant effect. Further characterization of the nature of the histamine response showed that UC-11MG cells express mepyramine-sensitive H1 receptors the activation of which causes both mobilization of Ca2+ from intracellular stores and entry of Ca2+ from the extracellular solution. No evidence was found for the presence of H2 receptors. The Ca2+i response was maximal at 300 microM histamine and was attenuated by increasing cell density. We suggest that this neurotransmitter may play a role in astrocytic function in the human CNS.
journal_name
Brain Resjournal_title
Brain researchauthors
Lucherini MJ,Gruenstein Edoi
10.1016/0006-8993(92)91676-6subject
Has Abstractpub_date
1992-10-02 00:00:00pages
193-201issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)91676-6journal_volume
592pub_type
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