Abstract：
:Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-administered atropine, a muscarinic receptor antagonist, in adult cats. At a T(a) of 23 degrees C , atropine (0.5 mg/kg) produced a significant reduction in REM sleep time that persisted for about 8 h of a 16 h recording period. Hypothalamic temperature fell below control levels for about 4 h following atropine. At a T(a) of 30 degrees C, the same dose of atropinehad no significant effect on REM sleep time, or hypothalamic temperature. These findings indicate the importance of considering the possible role of thermoregulation in drug-induced effects on REM sleep.
journal_name
Brain Resjournal_title
Brain researchauthors
Szymusiak R,Danowski J,McGinty Ddoi
10.1016/0006-8993(94)90184-8subject
Has Abstractpub_date
1994-02-04 00:00:00pages
115-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)90184-8journal_volume
636pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. In rat brain slices the release of glutamate evoked by verat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91254-c
更新日期：1992-10-09 00:00:00
abstract：:Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00797-t
更新日期：1995-10-30 00:00:00
abstract：:The importance of Na+/Ca2+ exchangers in the regulation of the physiological and pathological functions of the nervous system has been widely recognized. In this study, we used primary cultured E14.5 cortical neurons as a model system to study the possible roles of the reverse mode Na+/Ca2+ exchange activity in neurot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.042
更新日期：2008-03-27 00:00:00
abstract：:The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were signific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.022
更新日期：2004-12-03 00:00:00
abstract：OBJECTIVE:The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions. METHOD:EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146743
更新日期：2020-05-15 00:00:00
abstract：:(1)The brain stem of anaesthetized cats has been mapped between Horsley-Clark planes APO and P8.5 with electrical stimuli of low intensity in order to determine the areas which can produce excitatory of inhibitory influences on the spontaneously contracting, sympathetically denervated, urinary bladder. (2) Two inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90865-4
更新日期：1982-02-25 00:00:00
abstract：:Sheep with guide tubes implanted over the brain lateral ventricles, in order to facilitate episodic sampling of cerebrospinal fluid (CSF), were used to determine the effects of increasing cranial blood osmolality or electroconvulsive shock (ECS) on the permeability of the blood-brain barrier (BBB) to zinc. Zinc acetat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90513-b
更新日期：1990-01-15 00:00:00
abstract：:The ability of midbrain raphe (MR) cells grafted into serotonin-depleted brain to restore hippocampal responses to synaptically released serotonin was studied using a serotonin-releasing drug, D-fenfluramine (FFA). In normal rats, FFA enhances reactivity of the dentate gyrus (DG) to perforant-path stimulation, while s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91517-k
更新日期：1990-06-25 00:00:00
abstract：:Increasing adult neurogenesis in the hippocampal formation (HF) has been proposed as a potential foundation for neuronal repair in Alzheimer's disease (AD), but the evidence remains controversial. We used P8 strain of senescence-accelerated mice (SAMP8) as a model of AD to investigate changes in adult neurogenesis. We...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.039
更新日期：2011-05-10 00:00:00
abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:Separate series of adult rats were subjected to unilateral high cervical and low thoracic section of the rubrospinal tract and sacrificed 1-30 (cervical series) and 3-100 days (thoracic series) later. Local cerebral glucose utilization ([14C]2-DG method of Sokoloff et al.) was determined in the red nucleus and in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90035-0
更新日期：1984-12-24 00:00:00
abstract：:The presence and localization of synapsin I were investigated in the cat vestibular epithelium, using a rabbit anti-synapsin I antibody. The staining was performed by immunofluorescence or by a peroxidase-anti-peroxidase technique. A strong immunoreactivity was observed with both methods. It appeared as spherical patc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91176-5
更新日期：1986-10-08 00:00:00
abstract：:The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.059
更新日期：2009-04-24 00:00:00
abstract：:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01943-0
更新日期：2000-03-31 00:00:00
abstract：:The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activationa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.035
更新日期：2012-06-15 00:00:00
abstract：:Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91440-9
更新日期：1984-04-30 00:00:00
abstract：:Hormone-dependent sociosexual behaviors of the displaying individual regulate the abundance of estrogen receptor- and progesterone receptor-mRNA in sex steroid hormone-concentrating brain areas of the partner. This effect of behavior on gene expression in the brain is independent of the gonads. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01087-6
更新日期：1996-11-25 00:00:00
abstract：:The effects of different adrenoceptor agonists were investigated on mechanically induced Ca2+ waves in astroglial cells in astroglial-neuronal mixed cultures from rat hippocampus. In the initial part of the study some properties of the waves were characterized. The results show that the initiation of the Ca2+ waves wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00151-6
更新日期：1998-05-18 00:00:00
abstract：:The in vitro release of luteinizing hormone-releasing hormone (LHRH), prostaglandin (PG) E2 and leukotriene (LT) C4 from male rat median eminences (ME), was estimated by radioimmunoassay (RIA) in the presence of the catecholamines (CA), norepinephrine (NE) and dopamine (DA). NE increased the release of PGE2 in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90697-5
更新日期：1989-05-29 00:00:00
abstract：:Spontaneous and drug-induced interictal and post-ictal locomotor behavior of rats was investigated following electrical 'kindling' of different limbic structures at 3 brain sites which differ in the relative amount of innervation from dopamine cells of the ventral tegmentum: nucleus accumbens (N.Acc.), amygdala (AMYG)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91385-x
更新日期：1985-02-04 00:00:00
abstract：:Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90994-6
更新日期：1984-03-19 00:00:00
abstract：:We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90066-9
更新日期：1982-04-01 00:00:00
abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90556-3
更新日期：1993-10-29 00:00:00
abstract：:The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90546-9
更新日期：1986-03-26 00:00:00
abstract：:The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91297-e
更新日期：1991-04-05 00:00:00
abstract：:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.051
更新日期：2011-01-31 00:00:00
abstract：:Lithium and valproic acid are mood-stabilizing agents that are often used to manage the episodes of mania and depression that characterize bipolar disorder. These agents develop clinical efficacy with chronic treatment, but the neurobiological actions that contribute to their therapeutic effects remain unclear. The pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.102
更新日期：2006-06-06 00:00:00
abstract：BACKGROUND:Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder which is characterized by altered bowel habits. A growing number of studies investigate the association between IBS and cognitive impairments. Current studies report conflicting results regarding cognitive impairment in IBS patie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.036
更新日期：2019-09-15 00:00:00
abstract：:The effects of recombinant mouse stem cell factor (rmSCF) on paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the mossy fiber (MF)-CA3 pathway were examined in mouse hippocampal slices by recording field EPSPs. When PPF was measured before and 30 min after tetanic stimulation, the initial PPF positi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02879-2
更新日期：2002-08-16 00:00:00
abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03243-2
更新日期：2002-11-08 00:00:00
