TGF-beta1 increases tyrosine hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells.

abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...

journal_title：Brain research

authors： Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki S

更新日期：1998-04-20 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early A...

journal_title：Brain research

authors： Kiuchi K,Morikawa M,Taoka T,Nagashima T,Yamauchi T,Makinodan M,Norimoto K,Hashimoto K,Kosaka J,Inoue Y,Inoue M,Kichikawa K,Kishimoto T

更新日期：2009-09-01 00:00:00

abstract：:The single-unit activity of locus coeruleus noradrenergic (LC-NE) neurons was recorded in freely moving cats during naturally induced defense reactions. Defense reactions, consisting of arched back, piloerection, flattened ears and mydriasis, were elicited by exposing the cat either to a dog, or to a cat displaying ag...

journal_title：Brain research

authors： Levine ES,Litto WJ,Jacobs BL

更新日期：1990-10-29 00:00:00

abstract：:Sprague-Dawley rats were submitted to bilateral ventral hippocampus lesions 7 days after birth according to the Lipska and Weinberger's procedure for modeling schizophrenia. The aim of the present work was to better characterize their learning capacity. A double latent inhibition study was conducted using respectively...

journal_title：Brain research

authors： Angst MJ,Macedo CE,Guiberteau T,Sandner G

更新日期：2007-04-27 00:00:00

abstract：:The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...

journal_title：Brain research

authors： Low WC,Lewis PR,Terri ST

更新日期：1983-03-07 00:00:00

abstract：:Fast axoplasmic transport was examined in experimental nerve ligation and adriamycin-induced neuronal perikaryon lesions. Animals were sacrificed at precisely 3 and 4 h following the injection of [3H]leucine. In single ligated nerves, the 3 and 4 h down-flow rates, which include the time for neuronal processing of lab...

journal_title：Brain research

authors： Sahenk Z,Mendell JR

更新日期：1979-07-27 00:00:00

abstract：:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormo...

journal_title：Brain research

authors： Giardino L,Giuliani A,Bettelli C,Calzà L

更新日期：2002-01-25 00:00:00

abstract：:Cell death was due to activation of the receptor responsive to N-methyl-D-aspartate (NMDA). Even during a 30-min incubation, glutamate toxicity was unaffected by 5 microM CNQX and was greater than 90% blocked by 160 nM MK-801, a specific antagonist of the NMDA receptor. The extent of toxicity was dependent on the age ...

journal_title：Brain research

authors： Eimerl S,Schramm M

更新日期：1991-09-27 00:00:00

abstract：:Histochemical investigation by means of light and electron microscopy revealed the presence of dipeptidylpeptidase IV activity in Meissner corpuscles of macaque glabrous skin. The enzyme activity was found in fibroblast-like cells forming an incomplete capsule around the Meissner corpuscle. Distinct electron-dense rea...

journal_title：Brain research

authors： Dubový P

更新日期：1988-09-27 00:00:00

abstract：:To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...

journal_title：Brain research

authors： Onozuka M,Kishii K,Furuichi H,Sugaya E

更新日期：1983-06-20 00:00:00

abstract：:Neurodegenerative disorders have attracted attention in last decades due to their high incidence in the world. The p53/miR-34a axis triggers apoptosis and suppresses viability in multiple types of cells, but little is known about its role in neurodegenerative diseases. In this study, we showed that presenilin (PS)-2, ...

journal_title：Brain research

authors： Li LH,Tu QY,Deng XH,Xia J,Hou DR,Guo K,Zi XH

更新日期：2017-05-01 00:00:00

abstract：:Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...

journal_title：Brain research

authors： Alzheimer C,Röhrenbeck J,ten Bruggencate G

更新日期：1991-03-08 00:00:00

abstract：:In the context of injury to the corticospinal tract (CST), brainstem-origin circuits may provide an alternative system of descending motor influence. However, subcortical circuits are largely under subconscious control. To improve volitional control over spared fibers after CST injury, we hypothesized that a combinati...

journal_title：Brain research

authors： Harel NY,Yigitkanli K,Fu Y,Cafferty WB,Strittmatter SM

更新日期：2013-11-13 00:00:00

abstract：:Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glosso...

journal_title：Brain research

authors： Ichikawa H,Lin SC,Tsai SY,Tsai MJ,Sugimoto T

更新日期：2004-07-16 00:00:00

abstract：:The development of afferent projections to the cerebellum was studied by making small (20 nl) injections of True blue into the cerebella of neonatal rats under general anaesthesia. Neurones in all main precerebellar nuclei were labelled even in rats less than one day old. With the exception of the disappearance of sma...

journal_title：Brain research

authors： Payne JN,Bower AJ

更新日期：1988-04-01 00:00:00

abstract：:The biosynthetic activity of extra-hypothalamic vasopressin (VP) neurons in the bed nucleus of the stria terminalis (BNST) is regulated by gonadal steroids. These neurons have also been implicated in a number of behaviors that are impaired in aging. We previously reported that VP mRNA labelling in the BNST is decrease...

journal_title：Brain research

authors： Dobie DJ,Miller MA,Raskind MA,Dorsa DM

更新日期：1992-06-26 00:00:00

abstract：:We have previously shown that NS-7 [4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride] reduces the size of cerebral infarction measured by 2,3,5-triphenyltetrazolium chloride staining at 48 h after permanent middle cerebral artery occlusion (MCAO) in rats. To determine whether NS-7 improves...

journal_title：Brain research

authors： Tamura M,Aoki Y,Seto T,Itoh Y,Ukai Y

更新日期：2001-01-26 00:00:00

abstract：:Axonal projections of medial brain stem areas rich in serotonin-containing neurons were identified in layers I and II of cat medullary dorsal horn using EM autoradiography. Following [3H]amino acid injections into the brain stem, labeled axonal endings were found throughout layers I and II but were most numerous in la...

journal_title：Brain research

authors： Ruda MA,Allen B,Gobel S

更新日期：1981-01-26 00:00:00

abstract：:Immunohistochemical studies have suggested that corticotropin-releasing factor (CRF) was a transmitter of the olivocerebellar projection. We used in situ hybridization histochemistry with a 35S-labeled oligodeoxyribonucleotide probe for CRF mRNA to show that inferior olivary neurons of rats, baboons, and humans synthe...

journal_title：Brain research

authors： Young WS 3rd,Walker LC,Powers RE,De Souza EB,Price DL

更新日期：1986-11-01 00:00:00

abstract：:Previously we reported that several microRNAs (miRNA) are upregulated following experimentally induced traumatic brain injury (TBI) using both in vivo and in vitro approaches. Specific miRNAs were found to be sensitive to therapeutic hypothermia and may therefore be important targets for neuroprotective strategies. In...

journal_title：Brain research

authors： Truettner JS,Motti D,Dietrich WD

更新日期：2013-10-02 00:00:00

abstract：:The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostate sections from post mortem specimens of human spinal cord and lower medulla oblongata was studied by quantitative autoradiographic methods using [125I]YLFQPQRFamide as ligand. Samples were taken from five cases who had died with no hist...

journal_title：Brain research

authors： Allard M,Jordan D,Zajac JM,Ries C,Martin D,Monkouanga D,Kopp N,Simonnet G

更新日期：1994-01-07 00:00:00

abstract：:Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential impor...

journal_title：Brain research

authors： Zhu B,Moore GR,Zwimpfer TJ,Kastrukoff LF,Dyer JK,Steeves JD,Paty DW,Cynader MS

更新日期：1999-04-10 00:00:00

abstract：:Confocal microscopy and the Ca(2+)-sensitive fluorescent dye fluo-3 were used to study subcellular Ca2+ signals in embryonic, neonatal, and adult dorsal root ganglion (DRG) neurons in excised dorsal root ganglia. Optical images obtained from isolated whole embryonic and neonatal ganglia revealed a marked variability i...

journal_title：Brain research

authors： Utzschneider DA,Rand MN,Waxman SG,Kocsis JD

更新日期：1994-01-28 00:00:00

abstract：:We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chron...

journal_title：Brain research

authors： Balcioglu A,Wurtman RJ

更新日期：1998-11-30 00:00:00

abstract：:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...

journal_title：Brain research

authors： Takemoto Y,Semba R

更新日期：2006-02-16 00:00:00

abstract：:This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...

journal_title：Brain research

authors： Starbuck EM,Fitts DA

更新日期：1998-06-08 00:00:00

abstract：:Previous studies in piglets show that opioid-induced pial artery dilation was impaired following fluid percussion brain injury (FPI). This study was designed to determine the role of the newly described opioid nociceptin orphanin FQ (NOC/oFQ) in such impaired dilation to other opioids after FPI. CSF NOC/oFQ concentrat...

journal_title：Brain research

authors： Armstead WM

更新日期：2000-06-30 00:00:00

abstract：:The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chatterin...

journal_title：Brain research

authors： Kaplan GB,Leite-Morris KA,Sears MT

更新日期：1994-09-19 00:00:00

abstract：:Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. HCCAA is classified as a cerebral amyloid angiopathy and mutant cystatin C forms amyloid deposits in cerebral arteries resulting in fatal haemorrhagic strokes in young adu...

journal_title：Brain research

authors： Snorradottir AO,Isaksson HJ,Kaeser SA,Skodras AA,Olafsson E,Palsdottir A,Bragason BT

更新日期：2013-10-16 00:00:00

abstract：:To determine whether the sympathoexcitatory projection from the rostral ventrolateral medulla (RVL) to the sympathetic intermediolateral nucleus (IML) of the spinal cord might use glutamate as an excitatory transmitter, we performed a dual-label, transport and immunocytochemical ultrastructural study. Axon terminals w...

journal_title：Brain research

authors： Morrison SF,Callaway J,Milner TA,Reis DJ

更新日期：1991-10-18 00:00:00