Abstract：
:Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.
journal_name
Brain Resjournal_title
Brain researchauthors
Ichikawa H,Lin SC,Tsai SY,Tsai MJ,Sugimoto Tdoi
10.1016/j.brainres.2004.04.024subject
Has Abstractpub_date
2004-07-16 00:00:00pages
247-50issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304006171journal_volume
1014pub_type
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