Abstract:
:We have previously shown that NS-7 [4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride] reduces the size of cerebral infarction measured by 2,3,5-triphenyltetrazolium chloride staining at 48 h after permanent middle cerebral artery occlusion (MCAO) in rats. To determine whether NS-7 improves the pathological and behavioral changes at the chronic stage of MCAO, the effect of this compound on the cerebral infarction as well as the neurological and cognitive impairments was investigated 7 days after MCAO. Single or five daily injections of NS-7 (0.125-0.5 mg/kg, i.v.) significantly reduced the infarct volume and improved the neuronal dysfunction including the hind leg paralysis, walking disability and motor incoordination, and the deficit of passive avoidance task, although the neuroprotective efficacy was not different among these dosing regimens. On the other hand, the effects of single versus repeated injections of NS-7 at 0.1 or 0.2 mg/kg on the neurological symptoms were compared at 4 weeks after MCAO. At a lower dose, repeated but not single injection of NS-7 significantly improved the neurological symptoms, although the single injection was effective at a higher dose. From these findings, it is suggested that NS-7 reverses the behavioral and cognitive dysfunction observed at the chronic stage of cerebral ischemia by suppressing the cerebral infarction.
journal_name
Brain Resjournal_title
Brain researchauthors
Tamura M,Aoki Y,Seto T,Itoh Y,Ukai Ydoi
10.1016/s0006-8993(00)03168-1subject
Has Abstractpub_date
2001-01-26 00:00:00pages
170-6issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03168-1journal_volume
890pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Hypoxia preconditioning states that a sublethal hypoxia period will afford neuroprotection against a second harmful event. In our experiments, we carried out a procedure for the development of hypoxia preconditioning in adult male Wistar rats using hypoxic exposure (9% O(2); 91% N(2)) for 1 h. The protection against p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02388-x
更新日期:2000-06-16 00:00:00
abstract::The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90798-r
更新日期:1993-09-17 00:00:00
abstract::Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90096-2
更新日期:1983-01-01 00:00:00
abstract::The possibility of a functional relationship between noradrenaline and neurohypophyseal peptides in the control of cardiovascular function in the nucleus tractus solitarius of rats has been investigated. The hypotensive response to microinjections of noradrenaline (20 nmol) was abolished by simultaneous (but not prior...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90936-x
更新日期:1987-10-06 00:00:00
abstract::The objective was to further test the hypothesis that aluminum (Al) citrate transport across the blood-brain barrier is mediated by a monocarboxylate transporter (MCT). Speciation calculations showed that Al citrates were the predominant Al species under the conditions employed. Al citrate did not inhibit lactate upta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02234-5
更新日期:2002-03-15 00:00:00
abstract::Hippocampal corticosteroid receptors are regulated by corticosterone as well as by neurotransmitters, such as serotonin (5-HT). Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number. However...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00371-v
更新日期:1995-06-26 00:00:00
abstract::The cat substantia nigra (SN) pars reticulata (SNR) has been observed electron microscopically after ibotenic acid injections into the caudate nucleus (Cd) and horseradish peroxidase injections into the nucleus tegmenti pedunculopontinus pars compacta (TPC). As a result, degenerating striatal terminals were found to m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90683-5
更新日期:1989-04-17 00:00:00
abstract::An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90615-6
更新日期:1976-03-12 00:00:00
abstract::The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01208-6
更新日期:1999-01-30 00:00:00
abstract::In the present study, receptor specific compounds were infused via a microdialysis probe in the vicinity of the right locus coeruleus (LC). During the infusion of these compounds, the extracellular content of noradrenaline was recorded in the ipsilateral medial prefrontal cortex (mPFC) with a second microdialysis prob...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01062-8
更新日期:1999-03-27 00:00:00
abstract::Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90016-5
更新日期:1990-12-17 00:00:00
abstract::The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90706-3
更新日期:1989-05-29 00:00:00
abstract::The nicotine and muscarinic responses of differentiated mouse neuroblastoma cells from the clonal line N1E 115 to applied cholinergic agents were recorded using single channel and whole cell patch clamp techniques. An inward macroscopic current induced by acetylcholine (ACh) at the resting potential was blocked by cur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91252-7
更新日期:1986-11-19 00:00:00
abstract::We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.034
更新日期:2006-08-09 00:00:00
abstract::The weakly electric fish Apteronotus leptorhynchus produces electric organ discharges which are highly stable in waveform and frequency. Short-term modulations of these discharges, typically displayed during social interactions, are controlled by the prepacemaker nucleus (PPn). Neurons of this thalamic cell group inte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00818-9
更新日期:1996-11-11 00:00:00
abstract::Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90160-2
更新日期:1980-12-08 00:00:00
abstract::Using a specific antibody against each of the 4 catecholamine-synthesizing enzymes, dopamine or serotonin, we compared the localization of these substances in rat and mouse spinal cord with two kinds of fixative, such as paraformaldehyde and glutaraldehyde, and two types of sectioning technique, i.e. cryostat and micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90202-8
更新日期:1988-12-13 00:00:00
abstract::The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91740-x
更新日期:1994-03-14 00:00:00
abstract::In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.089
更新日期:2004-10-29 00:00:00
abstract::We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E2. Indwelling cannulas in the third ventricle of lambs (age, 5-31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for radioimmunoassay of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00946-n
更新日期:1995-11-27 00:00:00
abstract::[d-Ala(2)-d-Leu(5)]-Enkephalin (DADLE) has shown promising results in protecting neurons from damages. However, the mechanism for this protection is still under investigation. The current study was carried out to test the hypothesis that DADLE may regulate cellular transcription in neurons. SH-SY5Y cells and primary c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.04.007
更新日期:2014-05-27 00:00:00
abstract::Measurements of extracellular Ca2+ and K+ activities [( Ca2+]o, [K+]o) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]o of 0.035 +/- 0.17 mM (mean +/- S.D.; n = 17) and a biphasic change in [K+]o which consisted of an incre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91186-4
更新日期:1989-03-20 00:00:00
abstract::Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90621-7
更新日期:1977-04-15 00:00:00
abstract::This study examines projection to the cerebellar flocculus of eye movement-related neurons in the median and paramedian part of the cat pontine tegmentum between the trochlear and the abducens nucleus. They were identified by rhythmic activity related to horizontal vestibular nystagmus induced by sinusoidal rotation. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90465-5
更新日期:1980-02-10 00:00:00
abstract::In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90430-7
更新日期:1989-06-19 00:00:00
abstract::Astrocytes cultured from the brains of neonatal rat pups acquire at least two specializations of intramembrane particle distribution: 'assemblies' and gap junctions. The number and appearance of assemblies in the cultured astrocytes is not markedly influenced by the presence or absence of a collagen substrate, and the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90545-0
更新日期:1983-10-03 00:00:00
abstract::Seventy-two hybridoma lines that produce monoclonal antibodies to molecules of a rat synaptosomal plasma membrane fraction (SPM) were generated. The topographical distribution of the antigens in the cerebellum and other areas of the brain was studied by light microscopy immunocytochemistry. Some of the antibodies reco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90118-5
更新日期:1984-11-26 00:00:00
abstract::Mice lacking the GABA(A) receptor beta(3) subunit exhibit a profound disruption in thalamic circuitry. We have studied sleep in these mice under baseline conditions and following treatment with the benzodiazepine midazolam. Under baseline conditions, NREM sleep time did not differ between beta(3) subunit knockout mice...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03467-4
更新日期:2002-11-15 00:00:00
abstract::The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90468-3
更新日期:1986-01-08 00:00:00
abstract::Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90556-3
更新日期:1993-10-29 00:00:00