Post-stress changes in BDNF and Bcl-2 immunoreactivities in hippocampal neurons: effect of chronic administration of olanzapine.


:In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the effects of the chronic administration of olanzapine on the time course. Olanzapine is an atypical antipsychotic drug that has been shown to be neuroprotective in previous in vitro studies. We found: (1) the repeated restraint stress decreases the levels of expression of BDNF and Bcl-2 in hippocampal neurons; (2) the stress-induced decreases spontaneously recover to their pre-stress levels in 3 weeks after the last stress exposure; (3) administration of olanzapine for 1 week returns the expression of Bcl-2 to its pre-stress level, and the administration for 3 weeks causes an excessive expression of BDNF in hippocampal neurons. In the context of the lower levels of BDNF and Bcl-2, and structural brain abnormalities observed in patients with schizophrenia, our findings suggest that BDNF and Bcl-2 may be involved in the pathophysiology of schizophrenia and in the therapeutic action of atypical antipsychotic drugs.


Brain Res


Brain research


Luo C,Xu H,Li XM




Has Abstract


2004-10-29 00:00:00














  • Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures.

    abstract::In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the res...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cottrell GA,Robertson HA

    更新日期:1987-05-26 00:00:00

  • Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP).

    abstract::Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sanna A,Congeddu E,Porcella A,Saba L,Pistis M,Peis M,Marchese G,Ruiu S,Lobina C,Grayson DR,Gessa GL,Pani L

    更新日期:2003-03-28 00:00:00

  • Hippocampal EEG responses induced by carbachol and atropine infusions into the septum and the hippocampus in the urethane-anaesthetized rat.

    abstract::Infusion of 1 microgram of carbachol, a potent cholinergic agonist, into the lateral septum of the urethane-anaesthetized rat systematically caused the induction of clear-cut hippocampal theta (theta). However, infusion of an equivalent amount of the drug into the hippocampus, close to the recording electrode, failed ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Monmaur P,Ayadi K,Breton P

    更新日期:1993-12-24 00:00:00

  • Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.

    abstract::The stimulated (40 Hz) release of enkephalin from the myenteric plexus can be modulated by multiple types of opiate receptor. The direction of the modulation is not fixed but is bimodal. Both an inhibition and an enhancement of evoked release is observed depending on the concentration of opioid agonist that is used. E...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Xu H,Smolens I,Gintzler AR

    更新日期:1989-12-11 00:00:00

  • Axonal flow blockade induces alpha-CGRP mRNA expression in rat motoneurons.

    abstract::Axonal flow of motoneurons was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 microM) not considered likely to cause axonal degeneration. The number of motoneurons expressing alpha-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine applica...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Katoh K,Tohyama M,Noguchi K,Senba E

    更新日期:1992-12-18 00:00:00

  • Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction.

    abstract::Hypoxia-induced apoptosis of retinal ganglion cells (RGCs) is the major cause of progressive vision loss in numerous retinal diseases, including glaucoma and diabetic retinopathy. Taurine is a naturally occurring free amino acid that has been shown to have neurotrophic and neuroprotective properties in the retina. We ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chen K,Zhang Q,Wang J,Liu F,Mi M,Xu H,Chen F,Zeng K

    更新日期:2009-07-07 00:00:00

  • Potentiating role of interleukin-1beta (IL-1beta) and IL-1beta type 1 receptors in the medial hypothalamus in defensive rage behavior in the cat.

    abstract::Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hassanain M,Bhatt S,Zalcman S,Siegel A

    更新日期:2005-06-28 00:00:00

  • Effect of steroid competition and time on the uptake of (3H)corticosterone in the rat brain; an autoradiographic study.

    abstract::The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rhees RW,Grosser BI,Stevens W

    更新日期:1975-01-10 00:00:00

  • Identification of the cells of origin of a central pathway which sprouts following lesions in mature rats.

    abstract::Following unilateral destruction of the entorhinal cortical region of the adult rat, the denervated granule cells of the dentate gyrus are reinnervated as a result of the proliferation of a pathway from the surviving contralateral entorhinal area. The present study investigates the cells of origin of this lesion-induc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Steward O,Vinsant SL

    更新日期:1978-05-26 00:00:00

  • Neuron-specific mitochondrial degeneration induced by hyperammonemia and octanoic acidemia.

    abstract::The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Drewes LR,Leino RL

    更新日期:1985-08-12 00:00:00

  • Neurons evaluate both the amplitude and the meaning of signals.

    abstract::The neuronal threshold, which can be determined by the level of depolarization immediately prior to spike generation, is different for responses to conditioned and discriminated stimuli after conditioning. However, it is impossible to determine excitability within a response to stimuli that failed to generate a spike....

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tsitolovsky LE,Babkina NV

    更新日期:2002-08-09 00:00:00

  • Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by beta antagonists.

    abstract::The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of renin. Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release witho...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morton KD,Johnson MD,Van de Kar LD

    更新日期:1995-11-06 00:00:00

  • Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test.

    abstract::Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic system in mice is affected by EP-MRI. The short- and long-term effects of EP-MRI on immobil...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Aksoz E,Aksoz T,Bilge SS,Ilkaya F,Celik S,Diren HB

    更新日期:2008-10-21 00:00:00

  • Parvalbumin-immunoreactive neurons in the rat neostriatum: a light and electron microscopic study.

    abstract::Parvalbumin (PV)-immunoreactive neurons in rat neostriatum were studied under light and electron microscopes. A small number of neurons in the striatum were immunoreactive for PV (a Ca-binding protein). Most of them were also strongly immunoreactive for glutamate decarboxylase but were negative for NADPH-diaphorase ac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kita H,Kosaka T,Heizmann CW

    更新日期:1990-12-17 00:00:00

  • Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable spreading depression induced by microdialysis of elevated K+ in hippocampus of anesthetized rats.

    abstract::The potential shifts (delta Vo) associated with spreading depression (SD) were analysed with the help of multiple extracellular recording and ion-selective microelectrodes in the CA1 region of the dorsal hippocampus of anesthetized rats. Recurrent waves of SD were induced by perfusing high K+ solution through microdia...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Herreras O,Somjen GG

    更新日期:1993-05-07 00:00:00

  • Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats.

    abstract::The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kimura F,Mitsugi N,Arita J,Akema T,Yoshida K

    更新日期:1987-05-05 00:00:00

  • Volume regulation and metabolism of suspended C6 glioma cells: an in vitro model to study cytotoxic brain edema.

    abstract::The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kempski O,Chaussy L,Gross U,Zimmer M,Baethmann A

    更新日期:1983-11-21 00:00:00

  • Direct intracellular measurement of non-linear postreceptor transfer functions in dark and light adaptation in Limulus.

    abstract::Using one microelectrode inserted into a Limulus retinular cell, simultaneous recordings were made of the receptor potential evoked by light falling on that retinular cell and of the optic nerve action potentials generated in the eccentric cell coupled to that retinular cell. The postreceptor transfer function for sen...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang LT,Wasserman GS

    更新日期:1985-02-25 00:00:00

  • Glycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats.

    abstract::Strychnine-sensitive glycine receptors (GlyR) play a major role in the excitability of CNS neurons and are also a major target of many drugs including some general anesthetics and ethanol. The prefrontal cortex (PFC) is an important substrate responsible for cognitive function and for sedation, as well as hypnosis (un...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lu Y,Ye JH

    更新日期:2011-06-01 00:00:00

  • Integrated defence reaction elicited by excitatory amino acid microinjection in the midbrain periaqueductal grey region of the unrestrained cat.

    abstract::Unilateral microinjections (0.20 microliter) of the excitatory amino acids (EAA), L-aspartate (ASP), D,L-homocysteate (DLH) or kainate (KA) were made into the midbrain of freely moving cats. Injections of DLH (20 nmol) or ASP (200 nmol) made within the midbrain periaqueductal grey matter (PAG) consistently elicited a ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bandler R,Carrive P

    更新日期:1988-01-26 00:00:00

  • Morphometric study on the postnatal growth of the cerebellum of Australian aborigines and Caucasians.

    abstract::In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Riedel A,Klekamp J,Harper C,Kretschmann HJ

    更新日期:1989-10-16 00:00:00

  • Effects of ACTH4-10 on vestibular compensation.

    abstract::ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Flohr H,Lüneburg U

    更新日期:1982-09-23 00:00:00

  • An experimental anatomical study on the optic nerve fibers in the rat: courses of the accessory optic tract.

    abstract::By means of silver impregnation and an HRP method, courses of the accessory optic tract were examined in albino and pigmented rats. The accessory optic tract is composed of 3 fasciculi: anterior, lateral and dorsal. The anterior fasciculus gives off fibers to the subthalamic nucleus and terminates in the medial termin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamadori T,Yamauchi KE

    更新日期:1983-06-13 00:00:00

  • NMDA receptor antagonist blocks the bradycardic but not the pressor response to L-glutamate microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats.

    abstract::In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Colombari E,Bonagamba LG,Machado BH

    更新日期:1997-02-28 00:00:00

  • Calbindin D28k-containing splanchnic and cutaneous dorsal root ganglion neurons of the rat.

    abstract::Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kashiba H,Senba E,Ueda Y,Tohyama M

    更新日期:1990-10-01 00:00:00

  • Acute ethanol/cannabinoid-induced ataxia and its antagonism by oral/systemic/intracerebellar A1 adenosine receptor antisense in mice.

    abstract::Previous reports from our laboratory have demonstrated that ethanol- and cannabinoid-induced ataxia is modulated by cerebellar adenosine A(1) receptor because intracerebellar (i.c.b.) adenosine A(1) agonists potentiated and A(1) antagonist attenuated ataxia by these psychoactive drugs. In this study, the novel approac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dar MS,Mustafa SJ

    更新日期:2002-12-06 00:00:00

  • Human Thy-1: expression on the cell surface of neuronal and glial cells.

    abstract::The Thy-1 antigen is a cell surface glycoprotein found in neural tissue of all mammalian species so far studied. The distribution and amount of this antigen has been measured on 4 human neuronal and 2 neuroglial cell lines and on fresh tumour cells of neuronal origin. In 3 out of 4 neuronal lines (LAN-1, TR14, CHP 212...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kemshead JT,Ritter MA,Cotmore SF,Greaves MF

    更新日期:1982-03-25 00:00:00

  • Transient c-fos gene expression in cerebellar development and functional stimulation.

    abstract::This study examined the temporal appearance of c-fos expression in rat cerebella from birth to postnatal day 21 (P21) and following systemic kainic acid administration in adults. During development, Fos positive granule cells appeared first at P3 in caudal lobules and extended to all folia by P9. These reactive cells ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chen S,Ren YQ,Bing GY,Hillman DE

    更新日期:1998-06-08 00:00:00

  • Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study.

    abstract::Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Uchida S,Hara K,Kobayashi A,Otsuki K,Hobara T,Yamagata H,Watanabe Y

    更新日期:2010-02-26 00:00:00

  • Ganglioside-mediated enhancement of the cytoskeletal organization and activity in neuro-2a neuroblastoma cells.

    abstract::Our previous studies have demonstrated that a mixture of bovine brain gangliosides ( BBG ) applied to Neuro-2a neuroblastoma cells markedly increased the degree and rate of neurite formation. In the present study, the cytoskeletal basis for BBG -mediated neurite outgrowth was investigated by comparing cells grown in t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Spero DA,Roisen FJ

    更新日期:1984-03-01 00:00:00