Abstract:
:S-allyl cysteine (SAC), a sulfur containing amino acid derived from garlic, has been reported to have antioxidant, anti-cancer, antihepatotoxic and neurotrophic activity. This study was designed to examine the pre-treatment effects of SAC on cognitive deficits and oxidative damage in the hippocampus of intracerebroventricular streptozotocin (ICV-STZ)-infused mice. Mice pre-treated with SAC (30mg/kg) and vehicle (intraperitoneal; once daily for 15days) were bilaterally injected with ICV-STZ (2.57mg/kg body weight), whereas sham rats received the same volume of vehicle. The pre-treatment of this drug to Swiss albino mice has prevented the cognitive and neurobehavioral impairments. An increased latency and path length were observed in lesion, i.e. streptozotocin (STZ) group as compared to sham group and these were protected significantly in STZ group pre-treated with SAC. Levels of reduced glutathione (GSH) and its dependent enzymes (Glutathione peroxidase [GPx] and glutathione reductase [GR]) were decreased in STZ group as compared to sham group and pre-treatment of STZ group with SAC has protected their activities significantly. Conversely, the elevated level of thiobarbituric acid reactive substances (TBARS) in STZ group was attenuated significantly in SAC pre-treated group when compared with STZ lesioned group. Apoptotic parameters like DNA fragmentation, expression of Bcl2 and p53 were protected by the pre-treatment of SAC against STZ induced cognitive impairment. This study concludes that intervention of SAC could prevent free radicals associated deterioration of cognitive functions and neurobehavioral activities.
journal_name
Brain Resjournal_title
Brain researchauthors
Javed H,Khan MM,Khan A,Vaibhav K,Ahmad A,Khuwaja G,Ahmed ME,Raza SS,Ashafaq M,Tabassum R,Siddiqui MS,El-Agnaf OM,Safhi MM,Islam Fdoi
10.1016/j.brainres.2011.02.072subject
Has Abstractpub_date
2011-05-10 00:00:00pages
133-42eissn
0006-8993issn
1872-6240pii
S0006-8993(11)00428-8journal_volume
1389pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.017
更新日期:2007-04-13 00:00:00
abstract::Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90860-2
更新日期:1987-10-13 00:00:00
abstract::A group of neurons in the caudal nucleus of the solitary tract (NTS) processes preproglucagon to glucagon-like peptide 1 (GLP-1), GLP-2 and oxyntomodulin. Whereas the anorectic capacity of all three neuropeptides has been demonstrated, only relatively little is known of preproglucagon mRNA regulation in the brain stem...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.026
更新日期:2008-01-02 00:00:00
abstract::A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves th...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.03.039
更新日期:2014-10-10 00:00:00
abstract::Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90864-9
更新日期:1985-11-04 00:00:00
abstract::In a previous study the collateralization of the rubrospinal tract in the spinal cord of rat, cat and monkey was studied by means of the fluorescent retrograde double labeling technique. In the present study the existence of rubrospinal collaterals to the cerebellar interpositus nucleus (NI) has been studied using the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90816-8
更新日期:1983-04-04 00:00:00
abstract::A procedure is described for identifying the motor neurons innervating individual cockroach muscles by use of the retrograde transport of extracellularly injected horseradish peroxidase and the staining of cells in whole mount preparations. A modification of this procedure using wheat germ agglutinin covalently conjug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91141-6
更新日期:1982-09-23 00:00:00
abstract::In behaving cats, a cholinergic agonist, carbachol, or Ringer's solution were infused into the pontine reticular formation (PRF). Extracellular microelectrode recordings were obtained from single neurons located 1-4 mm from the infusion site. Sleep polygraphic variables were also recorded. Carbachol microinfusions int...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90137-x
更新日期:1986-10-29 00:00:00
abstract::Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized hu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.04.008
更新日期:2009-06-12 00:00:00
abstract::We report here the in vivo effects of estrogen (E2) on modulation of synaptic plasticity and the agonistic (estrogen-like) role of selective estrogen receptor modulator (SERM), tamoxifen (TAM) in the CA1 of the rat hippocampus. Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.027
更新日期:2007-02-09 00:00:00
abstract::Synaptic plasma membrane preparations from brain tissue have endogenous Ca2+-dependent phospholipase A2 activity. Characterization of this activity revealed that it was maximally active at 10(-7)-10(-5) M Ca2+ and pH 7.0. The enzyme had a Km of 62.0 microM and a Vmax of 98.0 nmol/mg/h. Calmodulin and prostaglandin F2 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90944-2
更新日期:1984-01-09 00:00:00
abstract::In the adult rabbit, the somatostatin-immunoreactive neurons are seen in all visual cortical layers, with the majority of them being found in layers II-III, V and VI. During postnatal development, we can see labeled cells in layer VI at birth and in layers V and VI on the 3rd day. The labeled cells are seen in layers ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91456-8
更新日期:1985-12-16 00:00:00
abstract::Repeated sensory exposure through frequent consumption of certain foods leads to changes in the processing of sensory cues. We investigated the influence of frequent minty chewing gum consumption on the neurobehavioral processing of intranasal trigeminal and olfactory stimuli. fMRI responses to a trigeminal minty odor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146663
更新日期:2020-03-01 00:00:00
abstract::The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map ascending pathways which are influenced by arousing electrical stimulation of the midbrain reticular formation (RET) in alert rats. The major finding was that RET stimulation produces selective patterns of metabolic activation and suppression in di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91190-4
更新日期:1985-09-30 00:00:00
abstract::We elucidated how Alzheimer-type pathologies of amyloid beta-protein (Abeta) and tau spatiotemporally emerge in brains of nontransgenic nonhuman primate, cynomolgus monkey, in the present study. To examine the accumulation of deposited Abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.005
更新日期:2010-02-22 00:00:00
abstract::During cerebral ischemia, dysregulated glutamate release activates N-methyl-d-aspartate (NMDA) receptors which promotes excitotoxicity and intracellular acidosis. Ischemia also induces cellular adenosine (ADO) release, which activates ADO receptors and reduces neuronal injury. The aim of this research was to determine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.115
更新日期:2006-04-12 00:00:00
abstract::The neurotoxic effects produced by ibotenic acid (IA) induced chemical lesions of the central nervous system (CNS) cholinergic system were examined on the opioid peptidergic system in adult rats. Forebrain cholinergic systems were bilaterally lesioned by the infusion of IA (1 or 5 micrograms/site) into the nucleus bas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90668-y
更新日期:1992-02-07 00:00:00
abstract::Hydroxyindole-O-methyltransferase (HIOMT) catalyses the last step of all the 5-methoxyindoles synthesized in the pineal gland. The synthetic activity of this neuroendocrine structure is driven not only by noradrenaline but also by various neuropeptides. Recently we have established (1) that one of these neuropeptides,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00556-3
更新日期:1998-08-10 00:00:00
abstract::While moderate calorie restriction (CR) in the absence of malnutrition has been consistently shown to have a systemic, beneficial effect against aging in several animals models, its effect on the brain microstructure in a non-human primate model remains to be studied using post-mortem histopathologic techniques. In th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.02.046
更新日期:2013-05-01 00:00:00
abstract::Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.015
更新日期:2009-03-19 00:00:00
abstract::Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats. The goal of this study was to determine whether lithium could potentiate pilocarpine-induced seizures in developing animals. Behavioral, electroencephalographic (EEG), and histopathological changes induced by systemic admin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(10)80015-0
更新日期:1992-06-26 00:00:00
abstract::After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90312-8
更新日期:1983-03-21 00:00:00
abstract::The present study evaluated the central effects of beta-funaltrexamine (B-FNA), a non-equilibrium antagonist of mu-opioid receptors and a reversible agonist of kappa-opioid receptors upon food intake in rats under freely-feeding, deprivation and glucoprivic conditions. B-FNA elicited distinct short-term and long-term ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91828-5
更新日期:1990-12-03 00:00:00
abstract::The laminin-alpha2 chain is a component of brain capillary basement membranes and appears also to be present in neurons of rat, rabbit, pig and non-human primate brain as evidenced by immunohistochemistry. In the present study, we have further characterized this very distinct neuronal laminin-alpha2 chain-like immunor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00420-4
更新日期:1997-08-01 00:00:00
abstract::The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90287-2
更新日期:1985-05-27 00:00:00
abstract::Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90772-1
更新日期:1976-07-30 00:00:00
abstract::To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91280-6
更新日期:1993-08-06 00:00:00
abstract::In decerebrate cats, the extracellular activities of neurons in the medial medullary reticular formation were studied during constant velocity off-vertical axis rotations (OVAR) in the clockwise (CW) and counterclockwise (CCW) directions (at 10 degrees tilt). Spontaneously active neurons demonstrated sinusoidal positi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00516-1
更新日期:1996-09-02 00:00:00
abstract::The effects of the epileptogenic agent pentylenetetrazole (PTZ) on membrane currents of native oocytes of Xenopus laevis were studied. PTZ elicits a response that consists of two inward currents. The first one is interpreted to be due to a decrease of potassium permeability since: (1) the input resistance is increased...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90225-k
更新日期:1991-07-05 00:00:00
abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90072-1
更新日期:1987-11-01 00:00:00