Abstract:
:Hydroxyindole-O-methyltransferase (HIOMT) catalyses the last step of all the 5-methoxyindoles synthesized in the pineal gland. The synthetic activity of this neuroendocrine structure is driven not only by noradrenaline but also by various neuropeptides. Recently we have established (1) that one of these neuropeptides, neuropeptide Y (NPY), stimulates specifically HIOMT activity in rat pinealocytes and (2) that the density of the NPY-immunoreactive (NPY-IR) fibers innervating the pineal gland of the European hamster (Cricetus cricetus) displays seasonal variations with a large increase in the late autumn. These findings have led us to evaluate a possible seasonal control of NPY on the European hamster pineal gland. We thus compared the nycthemeral patterns of pineal HIOMT activity and 5-methoxytryptophol (5-ML) content and of circulating MEL levels in European hamsters when NPYergic innervation is low (end of October) and when it is the highest (mid-December). We report in this study that HIOMT activity is significantly increased by 80% in mid-December compared with end of October. This increase is correlated with the appearance of a nycthemeral rhythm of pineal 5-ML levels (with a fourfold increase occurring in early dawn and decreasing slowly towards the end of the day). These observations suggest that NPY could be an important neurotransmitter involved in the seasonal control of the biochemistry of the European hamster pineal gland via a stimulatory effect on HIOMT activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Ribelayga C,Pévet P,Simonneaux Vdoi
10.1016/s0006-8993(98)00556-3subject
Has Abstractpub_date
1998-08-10 00:00:00pages
137-42issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00556-3journal_volume
801pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02358-6
更新日期:2000-02-14 00:00:00
abstract::To test the hypothesis that stimulation of glial peroxidase activity by estrogens may play a role in the pathogenesis of the previously reported degenerative changes in the hypothalamic arcuate nucleus that occur in female rats treated with a long-acting estrogen preparation, the cellular localization and number of pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90273-e
更新日期:1990-01-22 00:00:00
abstract::In normal subjects, electrical stimulation of trigeminal mucosal afferents (lingual nerve - V3) can elicit a short latency (12.5+/-0. 3 ms; mean+/-S.D.) reflex response in the ipsilateral genioglossus muscle (Maisonobe et al., Reflexes elicited from cutaneous and mucosal trigeminal afferents in normal human subjects. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02177-6
更新日期:2000-05-02 00:00:00
abstract::The regional distribution of proline biosynthetic enzymes, ornithine-delta-aminotransferase and delta 1-pyrroline-5-carboxylate reductase, in the rat brain, and basic conditions for proline synthesis from ornithine in rat and chicken brain slices and chicken retinas were investigated. The cerebral regions relating to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91022-5
更新日期:1987-06-16 00:00:00
abstract::The localization of the methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity-containing neurons in the rat lumbosacral spinal cord was immunohistochemically examined by an antiserum very specific to Met-Enk-Arg-Gly-Leu. The immunoreactive neurons occupied the positions corresponding to the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90804-3
更新日期:1987-03-17 00:00:00
abstract::Different mechanisms have been suggested to contribute to isoflurane-mediated neuroprotection. Previous studies have suggested that the protein Slit can abrogate neuronal death in mixed neuronal-glial cultures exposed to oxygen-glucose deprivation (OGD) and reperfusion (OGD/R). We hypothesized that isoflurane increase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.08.036
更新日期:2013-11-06 00:00:00
abstract::Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. Free-calcium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by TTX. The concept that 5-HT released from perikar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90877-1
更新日期:1984-06-18 00:00:00
abstract::The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few sub...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91413-7
更新日期:1986-01-01 00:00:00
abstract::It has recently been shown that the lobules 9 and 10 of the cerebellum contain high densities of dopamine D3 receptors (and almost no D2 receptors [Bouthenet, M.L., Souil, E., Martres, M.P., Sokoloff, P., Giros, B. and Schwartz, J.C., Brain Res., 564 (1991) 203-219; Sokoloff, P., Giros, B., Martres, M.P., Bouthenet, M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00964-x
更新日期:1996-10-21 00:00:00
abstract::alpha(1)-Adrenoceptors are concentrated in the locus coeruleus (LC) where they appear to regulate various active behaviors but have been difficult to stimulate effectively. The present study examined the behavioral, pharmacological and neural effects of possible stimulation of these receptors with 6-fluoronorepinephri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.049
更新日期:2009-09-29 00:00:00
abstract::It is well documented that VMAT2 protects nigrostriatal DA neurons against MPP(+) by sequestering it inside vesicles away from its mitochondrial site of neurotoxic action. However, the implication of the VMAT2 in the mechanism of action exerted by 6-OHDA has received little attention. Therefore, the aim of the present...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03333-x
更新日期:2003-11-07 00:00:00
abstract::The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system (RAS), is known to modulate waking and rapid eye movement (REM) sleep. REM sleep decreases between 10 and 30 days postnatally in the rat, with the majority occurring between 12 and 21 days. We investigated the possibility that c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.046
更新日期:2007-01-19 00:00:00
abstract::Much evidence suggests that the neuropeptide cholecystokinin (CCK) functions as a neurotransmitter or neuromodulator in the central nervous system. The CCKa receptor subtype in the nucleus accumbens has been demonstrated to potentiate the behavioral and neurophysiological effects of dopamine. Since the mesolimbic dopa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00918-g
更新日期:1995-11-20 00:00:00
abstract::There are marked increases in noradrenaline (NA) release during emergence from general anesthesia induced with volatile anesthestics. These changes in NA in the posterior hypothalamus of the rat were assessed by intracranial microdialysis. Sevoflurane and halothane in equipotent concentrations were used to obtain the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01080-7
更新日期:1996-01-15 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91434-6
更新日期:1994-01-28 00:00:00
abstract::The protein composition of subcellular fractions of the cerebella of normal and weaver, staggerer and nervous mutant mice and of X-irradiated rats are studied by polyacrylamide gel electrophoresis in sodium dodecyl sulphate. The patterns observed are compared with those of granular and Purkinje cells purified from rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90800-3
更新日期:1976-02-20 00:00:00
abstract::In 16-week-old Sprague-Dawley rats lightly anesthetized with pentobarbital, 5-HT (3-96 micrograms/kg, i.v.; n = 6) produced distinct pseudaffective responses and a dose-dependent (slope = 17.2 +/- 6.8 s/log10 dose) inhibition of the tail-flick (TF) reflex (ED50 = 32.6 +/- 9.2 micrograms/kg). In the same rats, a 1:1 co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90749-l
更新日期:1991-10-04 00:00:00
abstract::The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.10.008
更新日期:2014-01-13 00:00:00
abstract::The putative involvement of the dopaminergic innervation of the medial part of the prefrontal cortex (PFC) in short-term memory functioning was investigated by evaluating the effects of local infusions of dopaminergic drugs into the ventral part of the medial PFC of rats in an operant delayed-matching-to-position (DMT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00025-l
更新日期:1995-03-20 00:00:00
abstract::Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90087-9
更新日期:1988-01-01 00:00:00
abstract::There is an abundance of evidence suggesting that the area postrema (AP) is involved in the central actions of arginine-vasopressin (AVP) and angiotensin II (Ang II) on cardiovascular regulation. Furthermore, recent studies have shown that activation of the AP facilitates the response of nucleus tractus solitarius (NT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91323-4
更新日期:1994-06-06 00:00:00
abstract::We investigated the bilateral organization of the descending spinal sympathetic projections that subserve adrenomedullary stimulation caused by insulin hypoglycemia or 2-deoxyglucose (2DG) cellular glucopenia in adult rats with right-sided hemisection of the cord at C6-C7 (i.e. above the site of origin of the adrenal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90315-4
更新日期:1985-01-28 00:00:00
abstract::The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91463-0
更新日期:1986-04-30 00:00:00
abstract::The present study evaluated the ability of salicylic acid (SA) to attenuate long-term L-DOPA-induced 6-hydroxydopamine (6-OHDA) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. The production of 6-OHDA from dopamine in vitro from ferrous-ascorbate-dopamine (FAD) hydro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.010
更新日期:2010-07-16 00:00:00
abstract::Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90089-5
更新日期:1981-04-27 00:00:00
abstract::Sodium and potassium currents in the node of Ranvier decrease exponentially with time during long lasting voltage clamp experiments. This decline is strongly dependent on temperature (Q10 approximately 3). Thiamine and, particularly, its diand triphosphoric acid esters are shown to prevent this exponential decline of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90720-9
更新日期:1975-05-23 00:00:00
abstract:OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.014
更新日期:2016-12-15 00:00:00
abstract::The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.064
更新日期:2009-08-04 00:00:00
abstract::Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91639-i
更新日期:1991-01-25 00:00:00