Abstract:
:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellular calcium elevation with a similar time course. Reduction of extracellular calcium increased rather than decreased the InsP3-induced rise in calcium. These results suggest that small numbers of InsP3 molecules can trigger discrete and rapid releases of large amounts of calcium from intracellular stores. In some cells, InsP3 injection induces a delayed and prolonged elevation of intracellular calcium in addition to the brief bursts.
journal_name
Brain Resjournal_title
Brain researchauthors
Corson DW,Fein Adoi
10.1016/0006-8993(87)90860-2subject
Has Abstractpub_date
1987-10-13 00:00:00pages
343-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90860-2journal_volume
423pub_type
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