Inositol 1,4,5-trisphosphate induces bursts of calcium release inside Limulus ventral photoreceptors.

Abstract:

:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellular calcium elevation with a similar time course. Reduction of extracellular calcium increased rather than decreased the InsP3-induced rise in calcium. These results suggest that small numbers of InsP3 molecules can trigger discrete and rapid releases of large amounts of calcium from intracellular stores. In some cells, InsP3 injection induces a delayed and prolonged elevation of intracellular calcium in addition to the brief bursts.

journal_name

Brain Res

journal_title

Brain research

authors

Corson DW,Fein A

doi

10.1016/0006-8993(87)90860-2

subject

Has Abstract

pub_date

1987-10-13 00:00:00

pages

343-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90860-2

journal_volume

423

pub_type

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