Abstract：
:In Long-Evans Cinnamon (LEC) rats of three different ages (7, 13 and 32 weeks old) concentrations of Cu, Zn and Fe were measured in 8 regions of the brain. The LEC groups aged 7 and 13 weeks showed low concentrations of Cu in all regions compared to Long-Evans Agouti (LEA) rats. In 32-week-old LEC rats, however, Cu concentrations increased in 7 regions, in particular, significantly so in the striatum, hypothalamus, cerebellum, midbrain and cortex. Changes of Zn concentration were not found in any region. The Fe concentration increased in cortex and olfactory lobes. The three LEC groups showed a very high concentration of hepatic Cu and a low concentration of serum Cu compared to LEA rats. In LEC rats aged 32 weeks, however, hepatic Cu decreased and serum Cu increased compared to the other two LEC groups. These results suggest that the increase of the cerebral Cu concentration is closely related to the inherently abnormal Cu metabolism and then to the changes of Cu metabolism from about 13 weeks after birth.
journal_name
Brain Resjournal_title
Brain researchauthors
Sugawara N,Ikeda T,Sugawara C,Kohgo Y,Kato J,Takeichi Ndoi
10.1016/0006-8993(92)91587-5subject
Has Abstractpub_date
1992-08-21 00:00:00pages
287-90issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)91587-5journal_volume
588pub_type
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