Abstract：
:In order to obtain further insight into the interactions between the purinergic and dopaminergic pathways in the striatum, we studied both metabolisms simultaneously, using a microdialysis technique in 1-methyl-1,4-phenylpyridinium ion (MPP+) unilaterally-denervated conscious rats. In these rats the contralateral side was used as control. The perfusates were collected every 20-25 min using 4 mm dialysis probes, implanted in each striatum, and assayed for dopamine and purine metabolites. After MPP+ administration, all adenosine metabolites - with the exception of uric acid - and dopamine levels were significantly increased in the extracellular medium. However, the time-course change in dopamine level did not correlate with the adenosine and inosine time-courses, suggesting a different mechanism of liberation in response to MPP+ administration.
journal_name
Brain Resjournal_title
Brain researchauthors
Ballarin M,Reiriz J,Ambrosio S,Camps M,Blesa R,Mahy Ndoi
10.1016/0006-8993(89)90052-8subject
Has Abstractpub_date
1989-03-27 00:00:00pages
184-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90052-8journal_volume
483pub_type
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