Abstract:
:Hypoxia preconditioning states that a sublethal hypoxia period will afford neuroprotection against a second harmful event. In our experiments, we carried out a procedure for the development of hypoxia preconditioning in adult male Wistar rats using hypoxic exposure (9% O(2); 91% N(2)) for 1 h. The protection against pentylenetetrazol (PTZ)-induced seizures was studied. For this, rats were tested by a single injection of PTZ (55 mg/kg i.p.) on days 1-21 after hypoxia exposure. The hypoxia exposure significantly prevented the development of acute PTZ convulsion at different times after hypoxia. The present study was designed to determine the effect of N-t-butyl-alpha-phenylnitrone (PBN), an electron-trapping agent and free radical scavenger, on hypoxia preconditioning against PTZ seizures 7 days after hypoxia exposure. PBN abolished the protective action of hypoxia exposure. The generation of free hydroxyl radicals in the brains of animals exposed to hypoxia was determined in a second experiment. For this purpose, the rats were i. p. pretreated with 30 mg/kg PBN and NaCl, respectively, 20 min before the start of hypoxia exposure. Forty-five minutes later the rats were i.p. injected with 300 mg/kg sodium salicylate and once again exposed to hypoxia for 15 min. Immediately after that the animals were decapitated and the free hydroxyl radicals and the salicylate content were estimated in the whole brain without cerebellum. Hypoxia preconditioned animals pretreated with NaCl showed a significantly higher extent of free hydroxyl radicals in the brain compared with PBN-injected preconditioned animals and with naive and sham exposed controls. The results pointed out that the generation of free reactive oxygen species under hypoxic conditions in the brain is involved in the development of the hypoxic preconditioning phenomenon.
journal_name
Brain Resjournal_title
Brain researchauthors
Rauca C,Zerbe R,Jantze H,Krug Mdoi
10.1016/s0006-8993(00)02388-xsubject
Has Abstractpub_date
2000-06-16 00:00:00pages
147-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02388-Xjournal_volume
868pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90337-9
更新日期:1986-05-14 00:00:00
abstract::These experiments provide a direct test of the hypothesis that median raphe lesion- or PCPA-induced hyperactivity in the rat is mediated specifically by the hippocampus. Previous studies had shown that a marked depletion of hippocampal serotonin accompanied median lesion-induced hyperactivity. In the present studies, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90060-8
更新日期:1975-08-29 00:00:00
abstract::Effects of phenytoin (PHT) on the intracellular calcium and intracellular protein changes during pentylenetetrazole (PTZ)-induced bursting activity in the neurons of the Japanese land snail Euhadra peliomphala were examined. In the examination with a computer controlled electron probe X-ray microanalyzer, PHT clearly ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91510-0
更新日期:1985-02-18 00:00:00
abstract::The development of the dorsal root potential (DRP) and the responsiveness of primary afferent fibers to gamma-aminobutyric acid (GABA) were investigated in the isolated spinal cord of rat fetuses. At embryonic day 15.5, stimulation of the lumbar dorsal root was first effective in eliciting the DRP, which was not inhib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90127-0
更新日期:1985-01-01 00:00:00
abstract::Intraocular injections of ethylcholine mustard aziridinium ion (AF64A) in the rat depressed retinal choline acetyltransferase (ChAT) activity in a dose-dependent manner without any significant change in the content of amino acid neurotransmitters GABA, glycine, aspartate and glutamate. ChAT reduction was already detec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91466-7
更新日期:1988-01-26 00:00:00
abstract::Cytochrome aa3 (cyt aa3) is the main catalyst of cellular oxygen consumption. The properties of cyt aa3 will define the tissue oxygen requirements and provide an insight into energy supply and demand. Currently dual-wavelength (605-590 or 605-620 nm) reflectance spectrophotometry is used to monitor cyt aa3 redox state...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91236-3
更新日期:1985-12-23 00:00:00
abstract::Results of the preceding paper32 suggest that bulbo-pontine respiration related units (RRU) could be classed into 4 populations according to the relation of their peak firing frequency to the respiratory cycle: one inspiratory (I) and 3 expiratory (E) (early, mid and late). A further study of their spatial distributio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90668-5
更新日期:1976-09-17 00:00:00
abstract::On average, cells in areas 17, 18 or 19 of normal and stroboscopically reared cats respond with equal maximum firing rates to a narrow bar of light whether moving at the optimal velocity in the preferred direction of movement of flashed at the optimal position within the receptive field. Firing rates in the non-prefer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90223-7
更新日期:1981-09-07 00:00:00
abstract::Previous studies on the processing of fractions and proportions focused mainly on the processing of their overall magnitude information in the intraparietal sulcus (IPS). However, the IPS is also associated with domain-general cognitive functions beyond processing overall magnitude, which may nevertheless be involved ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.02.029
更新日期:2019-07-01 00:00:00
abstract::A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most pro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90085-0
更新日期:1987-02-17 00:00:00
abstract::The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.061
更新日期:2008-09-26 00:00:00
abstract::A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91529-5
更新日期:1986-12-10 00:00:00
abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91419-4
更新日期:1989-01-16 00:00:00
abstract::During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles for gene transfer to the adult central nervous system. In recent experiments, in the rat model of Parkinson's disease, all three vector s...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/s0006-8993(00)02915-2
更新日期:2000-12-15 00:00:00
abstract::Data reported up to now on neuron-glia relationships, show that neuron cell bodies and glial cells are separated by a narrow intercellular cleft which is considered as the microenvironment of the nervous system, and where neuron-glia exchange occurs. We present here evidence that neuron perikarya and ensheathing glial...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91394-0
更新日期:1985-02-04 00:00:00
abstract::Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90315-9
更新日期:1984-12-10 00:00:00
abstract::The presence and localization of synapsin I were investigated in the cat vestibular epithelium, using a rabbit anti-synapsin I antibody. The staining was performed by immunofluorescence or by a peroxidase-anti-peroxidase technique. A strong immunoreactivity was observed with both methods. It appeared as spherical patc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91176-5
更新日期:1986-10-08 00:00:00
abstract::The effects of chronic administration of naloxone, morphine and met-enkephalin on benzodiazepine (BDZ) receptor binding in rat brain were determined 2 and 50 days after treatments were accomplished. Two days after naloxone treatment (75 micrograms/h s.c. for 14 days), enhanced BDZ receptor binding was observed in cing...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91668-i
更新日期:1993-05-28 00:00:00
abstract::Nissl cytoarchitectural and MAP-2 immunocytochemical evidence is presented for the radial organisation of neurons and neural processes in the human medial prefrontal cortex (mPFC). In Brodmann areas 25, 32, and 32', neuronal cell bodies are organised into short vertical stacks of 15-19 somata with pyramidal cells apic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.054
更新日期:2003-12-05 00:00:00
abstract::Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90385-z
更新日期:1993-02-26 00:00:00
abstract::Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90721-7
更新日期:1983-09-12 00:00:00
abstract::Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91329-d
更新日期:1992-10-16 00:00:00
abstract::Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.056
更新日期:2012-04-23 00:00:00
abstract::At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90147-n
更新日期:1991-08-23 00:00:00
abstract::The retinotopic organization of the expanded projection to the ipsilateral colliculus was studied electrophysiologically in 12 adult albino rats with one eye removed at birth. For comparison, the contralateral projection was rather variable in the representation of the nasotemporal axis of the retina along the rostroc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90200-2
更新日期:1984-11-12 00:00:00
abstract::After treatment with pentylenetetrazol (PTZ), cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels were determined in rat hippocampus and cortex at different time points. In the temporal cortex treatment with 60 mg/kg PTZ, i.p., induced increases of CCK mRNA and CCK-LI levels at 2 days after the in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01179-7
更新日期:1998-01-01 00:00:00
abstract::Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.025
更新日期:2006-09-07 00:00:00
abstract::Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.050
更新日期:2006-12-06 00:00:00
abstract::The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02271-6
更新日期:2003-04-18 00:00:00
abstract::Choline molecules are needed for the synthesis of acetylcholine and phospholipids in the mammalian brain. An enzymatic activity capable of forming lecithin (phosphatidylcholine) from the step-by-step methylation of phosphatidylethanolamine is identified in the bovine brain. This enzyme(s), phosphatidylethanolamine-N-m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90447-5
更新日期:1979-12-28 00:00:00