Abstract：
:A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the cueing epoch were less common (31%) and less robust than in the choice epoch, although the animal made essentially the same arm movement in both cases. Only 14% of the task-related NBM cells had significant changes in discharge rate in the delay period, and none of these responded differentially for the two positions indicated in the preceding cueing epoch. These findings do not support a role of the NBM in the differential responses of cortical neurons in delayed response tasks, but they provide further evidence for NBM involvement in aspects of reward acquisition.
journal_name
Brain Resjournal_title
Brain researchauthors
Richardson RT,DeLong MRdoi
10.1016/0006-8993(86)91529-5subject
Has Abstractpub_date
1986-12-10 00:00:00pages
364-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)91529-5journal_volume
399pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90014-2
更新日期：1994-09-26 00:00:00
abstract：:The regulation of corticosteroid receptor expression in the rat brain by adrenal steroids remains controversial. The results of in vivo studies [Brinton and McEwen, 1988; Luttge et al., 1989] suggest that activation of type I receptors can modulate both mineralocorticoid (MR; type I) and glucocorticoid (GR; type II) r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90174-0
更新日期：1994-02-04 00:00:00
abstract：:Involvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test sess...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01040-8
更新日期：1996-01-15 00:00:00
abstract：:Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.022
更新日期：2018-08-15 00:00:00
abstract：:An involvement of serotonin (5-HT) 1A receptors in the etiology of psychiatric disorders has been suggested. Hypo-responsiveness of the 5-HT1A receptor is linked to anxiety and constitutive deletion of the 5-HT1A receptor produces anxiety-like behaviors in the mouse. Evidence that 5-HT1A receptor inactivation increase...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02271-5
更新日期：2001-05-25 00:00:00
abstract：:Dopamine (DA) and noradrenaline (NA) extracellular levels have been measured by microdialysis in the medial frontal cortex (MFC), nucleus accumbens (NAc) and caudate-putamen (CP) under baseline conditions in awake and halothane-anaesthetized rats, and after application of three types of stimuli which are likely to act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90711-h
更新日期：1992-05-29 00:00:00
abstract：:Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.009
更新日期：2004-08-06 00:00:00
abstract：:Double immunostaining for c-fos and oxytocin (OXY) was used to study the topography and time course of the metabolic activation of the hypothalamic oxytocinergic system upon osmotic stress in the male rat. Animals injected i.p. with hypertonic saline expressed c-fos-like immunoreactivity (FLI) in the paraventricular (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91342-c
更新日期：1992-08-14 00:00:00
abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90864-9
更新日期：1985-11-04 00:00:00
abstract：:The efficacy of 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-Androstanediol; 3 alpha-Diol) and 4-pregnen-3,20-dione (progesterone; P) in promoting analgesia was investigated. Ovariectomized rats received daily injections of 3 alpha-Diol (0.6, 3.0, 6.0 and 7.5 mg/kg) or vehicle and twice daily injections of estradi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01118-8
更新日期：1996-02-12 00:00:00
abstract：:Immunohistochemical staining with mouse monoclonal antibody R24 recognizing the ganglioside GD3 was used to study the distribution of GD3 in the human brain. Positive staining was primarily found in the surrounding neuropil of many neuronal groups in the brainstem and spinal cord, cerebellum, retina and dentate gyrus ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90642-5
更新日期：1984-12-17 00:00:00
abstract：:The prognosis of patients with malignant glioma remains extremely poor despite surgery and improvements in radio- and chemo-therapies. We recently showed that marrow-isolated adult mutilineage inducible (MIAMI) cells, a subpopulation of human mesenchymal stromal cells (MSCs), can serve as cellular carriers of drug-loa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.030
更新日期：2012-09-14 00:00:00
abstract：:Because previous studies have emphasized the importance of the amygdala in the therapeutic actions of benzodiazepines and described differences in benzodiazepine receptor distribution between human and rat, this study examined the distribution of multiple benzodiazepine receptors in normal human amygdala by light micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90730-8
更新日期：1983-10-16 00:00:00
abstract：:Nuclear retention of radioactivity was studied in neural estrogen target cells 15 min-7 h after i.v. injection of [3H]estradiol. Maximal uptake occurred by 15 min. Cells of the medial preoptic nucleus retained the label longer than did those of the medial amygdaloid nucleus. Cells of the ventromedial nucleus and arcua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90761-7
更新日期：1981-12-14 00:00:00
abstract：:Recently it was reported that there is an increase in monoamine oxidase B (MAO-B) activity in post-mortem brains of patients with Alzheimer's disease. It was postulated that this increase in MAO-B activity was due to gliosis associated with neuronal degeneration. The aim of the present investigation was to evaluate th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91249-3
更新日期：1989-01-09 00:00:00
abstract：:The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.12.021
更新日期：2017-02-15 00:00:00
abstract：:We investigated the effects of inverting facial contour (hair and chin) and features (eyes, nose and mouth) on processing for static and dynamic face perception using magnetoencephalography (MEG). We used apparent motion, in which the first stimulus (S1) was replaced by a second stimulus (S2) with no interstimulus int...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.091
更新日期：2011-04-06 00:00:00
abstract：:Rodent models of focal and global ischemia were used to examine caspase activation. Several readouts were employed on identical tissue to provide correlative measurement of caspase induction, activation and enzymatic activity. In a rat focal ischemia model, caspase-3 enzymatic activity, as recorded by DEVD-AMC cleavag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02846-4
更新日期：2003-08-29 00:00:00
abstract：:Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90291-8
更新日期：1977-02-18 00:00:00
abstract：:The effects of sodium valproate on extracellularly recorded spontaneous neuronal activity and its interaction with GABA-induced inhibition were assessed in the rat medial basal hypothalamus both in situ and in explant culture. In situ, valproate enhanced the spontaneous rate in 14 of 20 neurons sampled, 6 neurons were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90288-2
更新日期：1981-08-24 00:00:00
abstract：:The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147237
更新日期：2021-01-02 00:00:00
abstract：:The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system (RAS), is known to modulate waking and rapid eye movement (REM) sleep. REM sleep decreases between 10 and 30 days postnatally in the rat, with the majority occurring between 12 and 21 days. We investigated the possibility that c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.046
更新日期：2007-01-19 00:00:00
abstract：:The possible involvement of the nitric oxide (NO)-cyclic GMP (cGMP)-protein kinase G (PKG) pathway on bovine lactoferrin (BLF)-induced spinal antihyperalgesic activity was elucidated in sciatic nerve injured rats. Intrathecal BLF reduced thermal hyperalgesia in a dose-dependent manner. Pretreatment with NG-L-nitro-arg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.004
更新日期：2008-05-13 00:00:00
abstract：:The brain 5-HT1A receptor system in male wild house mice selected for high and low offensive aggression was investigated by autoradiographic analysis of in situ hybridization and radioligand binding. In high-aggressive mice, characterized by a short attack latency, the rise in plasma corticosterone concentration durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00723-8
更新日期：1996-10-14 00:00:00
abstract：:Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.013
更新日期：2013-01-23 00:00:00
abstract：:To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146674
更新日期：2020-04-01 00:00:00
abstract：:Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03345-0
更新日期：2002-10-18 00:00:00
abstract：:The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00960-3
更新日期：1998-11-23 00:00:00
abstract：:A phosphorylated, approximately 110 kDa laminin-binding protein (110 kDa LBP) from mouse brain has been previously identified. This protein recognizes a neurite-outgrowth promoting 19-amino acid synthetic peptide (PA 22-2) derived from the laminin A chain. In the present study, an antibody against the 110 kDa LBP was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90356-z
更新日期：1991-08-02 00:00:00
abstract：:Morphologic and metabolic aspects of androgen effects on the developing spinal cord were studied in organotypic cultures of the E13 (embryonic day 13) fetal mouse lumbosacral spinal cord, maintained as either hemisected, homologous explant pairs co-cultured with bulbocavernosus muscle (morphologic studies), or as whol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90769-4
更新日期：1987-03-17 00:00:00
