Involvement of the nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway in the antihyperalgesic effects of bovine lactoferrin in a model of neuropathic pain.

abstract：:The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...

journal_title：Brain research

authors： Crunelli V,Mayer ML

更新日期：1984-10-08 00:00:00

abstract：:gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze ...

journal_title：Brain research

authors： Ungerer A,Schmitz-Bourgeois M,Mélan C,Boulanger Y,Reinbolt J,Amiri I,de Barry J

更新日期：1988-04-19 00:00:00

abstract：:We investigated the ability of GM1 to induce phosphorylation/activation of the extracellular-regulated protein kinases (ERKs) in the striatum, hippocampus and frontal cortex of aged male Sprague-Dawley rats. Three different treatment paradigms were used: a single application of GM1 to brain slices in situ, a single in...

journal_title：Brain research

authors： Mo L,Ren Q,Duchemin AM,Neff NH,Hadjiconstantinou M

更新日期：2005-08-30 00:00:00

abstract：:Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...

journal_title：Brain research

authors： Cho JH,Choi IS,Lee MG,Jang IS

更新日期：2012-05-21 00:00:00

abstract：:Many lines of evidence support the importance of the nucleus accumbens (NAC) for ethanol-reinforced behavior. The nature of the neuronal activity that occurs in this region during ethanol self-administration is not known. We recorded from ensembles of single-units primarily located within the shell of the NAC during o...

journal_title：Brain research

authors： Janak PH,Chang JY,Woodward DJ

更新日期：1999-01-30 00:00:00

abstract：:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...

journal_title：Brain research

authors： Wolf G,Keilhoff G

更新日期：1984-05-01 00:00:00

abstract：:The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...

journal_title：Brain research

authors： Baranowska-Bosiacka I,Gutowska I,Marchlewicz M,Marchetti C,Kurzawski M,Dziedziejko V,Kolasa A,Olszewska M,Rybicka M,Safranow K,Nowacki P,Wiszniewska B,Chlubek D

更新日期：2012-01-30 00:00:00

abstract：:Large neurons in the neostriatum of patients with Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) were investigated topographically, histologically and ultrastructurally. The number of large neurons whose nuclear area is greater than 101 microns2 was uniformly decreased in the neostriatum in PSP, but...

journal_title：Brain research

authors： Oyanagi K,Takahashi H,Wakabayashi K,Ikuta F

更新日期：1991-03-29 00:00:00

abstract：:Auditory stimulation has been shown to increase REM sleep periods in cats and humans. This effect has been attributed to an elevation of the level of excitability in a variety of brain stem neuronal groups. Fos-like immunostaining (FLI) has been useful in constructing maps of post-synaptic neuronal activity with singl...

journal_title：Brain research

authors： Merchant-Nancy H,Vázquez J,Aguilar-Roblero R,Drucker-Colín R

更新日期：1992-05-08 00:00:00

abstract：:The distribution and subcellular localization of AH9 antigen, recognized by a monoclonal antibody AH9, were examined in rat brain. Highest expression was observed in the lamina lucidum of the dentate gyrus of the rat hippocampus. Synaptic subfields of other limbic areas also expressed AH9 antigen at a substantial leve...

journal_title：Brain research

authors： Fukuyama R,Rapoport SI

更新日期：1996-05-06 00:00:00

abstract：:Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...

journal_title：Brain research

authors： Maley BE,Panneton WM

更新日期：1988-03-01 00:00:00

abstract：:Two neuropeptides reacting with antibodies directed against the C-terminal region of somatostatin 28(1-12) were purified to homogeneity from rat brain extracts. Amino acid analysis revealed that the larger peptide (8 kdaltons) consisted of 76 amino acids. Microsequencing established its aminoterminal structure as: Ala...

journal_title：Brain research

authors： Benoit R,Böhlen P,Esch F,Ling N

更新日期：1984-10-08 00:00:00

abstract：:Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...

journal_title：Brain research

authors： Sunanda,Rao MS,Raju TR

更新日期：1995-10-02 00:00:00

abstract：:As measured by extracellular single-cell recording, the responses to adenosine triphosphate (ATP) by ATP-sensitive chemoreceptors (ATP cells) on the olfactory organ of the spiny lobster are markedly suppressed by adenosine diphosphate (ADP), adenosine monophosphate (AMP) and to a lesser extent, adenosine, when each is...

journal_title：Brain research

authors： Gleeson RA,Carr WE,Trapido-Rosenthal HG

更新日期：1989-09-11 00:00:00

abstract：:Reduced glutathione (GSH) plays an important role in cellular protection against damage from free radicals and other electrophiles. GSH in the rat central nervous system was quantitatively analyzed. In adult brain, tissue from the cerebellum and cerebrum had higher GSH levels than that from the brainstem and spinal co...

journal_title：Brain research

authors： Kudo H,Kokunai T,Kondoh T,Tamaki N,Matsumoto S

更新日期：1990-03-19 00:00:00

abstract：:Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...

journal_title：Brain research

authors： Sandberg K,Coyle JT

更新日期：1985-12-02 00:00:00

abstract：:We carried out ligand binding experiments on membranes from rat brain cortical grey matter using radioiodinated beta/A4 8-17, with non-specific binding determined by the addition of 10 microM unlabelled peptide. Specific, reversible binding amounted to 60-75% of total binding and showed a clear dependence on time, tem...

journal_title：Brain research

authors： Allsop D,Yamamoto T,Kametani F,Miyazaki N,Ishii T

更新日期：1991-06-14 00:00:00

abstract：:The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored the possible underlying mechanism by examining metallothionein (MT)-1 and -2 induction in vivo. Cilostazol (30 mg/kg) was intraperitoneally administered at 12 h...

journal_title：Brain research

authors： Wakida K,Morimoto N,Shimazawa M,Hozumi I,Nagase H,Inuzuka T,Hara H

更新日期：2006-10-20 00:00:00

abstract：:The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...

journal_title：Brain research

authors： Fukuda H,Tomimatsu T,Watanabe N,Mu JW,Kohzuki M,Endo M,Fujii E,Kanzaki T,Murata Y

更新日期：2001-08-10 00:00:00

abstract：:Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more...

journal_title：Brain research

authors： Engeset RM,Ritter RC

更新日期：1980-11-24 00:00:00

abstract：:A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...

journal_title：Brain research

authors： Baertling F,Kokozidou M,Pufe T,Clarner T,Windoffer R,Wruck CJ,Brandenburg LO,Beyer C,Kipp M

更新日期：2010-04-22 00:00:00

abstract：:The nicotine and muscarinic responses of differentiated mouse neuroblastoma cells from the clonal line N1E 115 to applied cholinergic agents were recorded using single channel and whole cell patch clamp techniques. An inward macroscopic current induced by acetylcholine (ACh) at the resting potential was blocked by cur...

journal_title：Brain research

authors： Takeda K,Shimahara T,Tauc L,Berwald-Netter Y

更新日期：1986-11-19 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

journal_title：Brain research

authors： Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

更新日期：2009-01-19 00:00:00

abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...

journal_title：Brain research

authors： Galvez R,Gopal AR,Greenough WT

更新日期：2003-05-02 00:00:00

abstract：:Preconditioning describes a variety of treatments that induce neurons to become more resistant to a subsequent ischemic insult. How preconditioned neurons adapt to subsequent ischemic stress is not fully understood, but is likely to involve multiple protective mechanisms. We hypothesized hypoxic preconditioning induce...

journal_title：Brain research

authors： Arthur PG,Lim SC,Meloni BP,Munns SE,Chan A,Knuckey NW

更新日期：2004-08-13 00:00:00

abstract：:Dissociated striatal neurons exhibited increased neurite outgrowth when co-cultured with myenteric plexus explants. Enriched enteric neurons or enriched enteric glia produced a less marked response; non-ganglionic cells had no effect. Increases in striatal neuron and glial cell numbers were seen in all co-cultures. Te...

journal_title：Brain research

authors： Höpker VH,Saffrey MJ,Burnstock G

更新日期：1994-06-20 00:00:00

abstract：:The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...

journal_title：Brain research

authors： Schwartzkroin PA,Prince DA

更新日期：1980-02-03 00:00:00

abstract：:Auditory working memory (WM) is the cognitive faculty that allows us to actively hold and manipulate sounds in mind over short periods of time. We develop here a particular perspective on WM for non-verbal, auditory objects as well as for time based on the consideration of possible parallels to visual WM. In vision, t...

journal_title：Brain research

authors： Joseph S,Teki S,Kumar S,Husain M,Griffiths TD

更新日期：2016-06-01 00:00:00

abstract：:The focal ischemia obtained in an animal model of middle cerebral artery occlusion (MCAo) causes the "core" of damage in the striatum and the "penumbra" of damage in the fronto-parietal cortex. The latter is mainly functionally affected and shows changes in nNOS and iNOS expression during the acute phase of ischemia. ...

journal_title：Brain research

authors： Vannucchi MG,Bizzoco E,Corsani L,Gianfriddo M,Pedata F,Faussone-Pellegrini MS

更新日期：2007-02-09 00:00:00

abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...

journal_title：Brain research

authors： Jiao X,Paré WP,Tejani-Butt SM

更新日期：2006-02-16 00:00:00