Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain.

Abstract:

:Reduced glutathione (GSH) plays an important role in cellular protection against damage from free radicals and other electrophiles. GSH in the rat central nervous system was quantitatively analyzed. In adult brain, tissue from the cerebellum and cerebrum had higher GSH levels than that from the brainstem and spinal cord. Infant cerebrum and cerebellum contained lower levels of GSH than adult cerebrum and cerebellum. These data seem to suggest that the brainstem and spinal cord in adults, and the cerebrum and cerebellum in infants, are more vulnerable to injury by free radical-like radiation than the cerebrum and cerebellum in adults.

journal_name

Brain Res

journal_title

Brain research

authors

Kudo H,Kokunai T,Kondoh T,Tamaki N,Matsumoto S

doi

10.1016/0006-8993(90)90178-e

subject

Has Abstract

pub_date

1990-03-19 00:00:00

pages

326-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(90)90178-E

journal_volume

511

pub_type

杂志文章
  • Distribution of effects of haloperidol on energy metabolism in the rat brain.

    abstract::The effects of the putative dopaminergic antagonist, haloperidol (0.01-10 mg/kg, i.v.), on cerebral glucose utilization in 43 anatomically discrete regions of the rat brain have been examined by the quantitative autoradiographic 2-deoxyglucose technique. Dose-dependent reductions in glucose utilization were observed i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)91122-2

    authors: McCulloch J,Savaki HE,Sokoloff L

    更新日期:1982-07-08 00:00:00

  • NAD(P)H oxidase in paraventricular nucleus contributes to the effect of angiotensin II on cardiac sympathetic afferent reflex.

    abstract::We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.01.113

    authors: Zhang Y,Yu Y,Zhang F,Zhong MK,Shi Z,Gao XY,Wang W,Zhu GQ

    更新日期:2006-04-12 00:00:00

  • Projections from the subfornical organ to the supraoptic nucleus in the rat: ultrastructural identification of an interposed synapse in the median preoptic nucleus using a combination of neuronal tracers.

    abstract::The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90708-4

    authors: Oldfield BJ,Hards DK,McKinley MJ

    更新日期:1991-08-30 00:00:00

  • Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration.

    abstract::Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.02.021

    authors: Duckworth EA,Butler TL,De Mesquita D,Collier SN,Collier L,Pennypacker KR

    更新日期:2005-04-25 00:00:00

  • Protection of oxidative preconditioning against apoptosis induced by H2O2 in PC12 cells: mechanisms via MMP, ROS, and Bcl-2.

    abstract::The present study is designed to investigate the effects of preconditioning with different doses of hydrogen peroxide (H2O2) on oxidative stress-induced apoptosis and the changes in mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) level, and expression of Bcl-2 during H2O2 preconditi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.07.072

    authors: Tang XQ,Feng JQ,Chen J,Chen PX,Zhi JL,Cui Y,Guo RX,Yu HM

    更新日期:2005-09-28 00:00:00

  • Membrane properties of rat magnocellular neuroendocrine cells in vivo.

    abstract::Membrane properties of rat magnocellular neuroendocrine cells (MNCs) were examined during intracellular recordings in vivo. Current-clamp experiments revealed sustained outward rectification positive to -55 mV and transient outward rectification of depolarizing responses elicited from negative holding potentials. Trai...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90535-4

    authors: Bourque CW,Renaud LP

    更新日期:1991-02-01 00:00:00

  • gamma-Aminobutyric acid and somatostatin immunoreactivity in the visual cortex of normal and dark-reared rats.

    abstract::Our previous single unit and ultrastructural studies of visual cortex of dark-reared rats revealed an impairment of intracortical inhibitory mechanisms [2,3,5]. Neurochemical changes in inhibitory neurotransmitter and/or neuropeptides, such as gamma-aminobutyric acid (GABA) and somatostatin (SS), respectively, may con...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00553-3

    authors: Benevento LA,Bakkum BW,Cohen RS

    更新日期:1995-08-21 00:00:00

  • Immunocytochemical localisation of neuropeptide Y and 5-hydroxytryptamine in a subpopulation of amine-handling intracardiac neurones that do not contain dopamine beta-hydroxylase in tissue culture.

    abstract::The colocalisation of neuropeptide Y (NPY)- and 5-hydroxytryptamine (5-HT)-immunoreactivities in intracardiac neurones in dissociated cultures from the atria and interatrial septum of newborn guinea pig heart was demonstrated by the sequential application of specific antisera which were visualised by two different flu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90541-5

    authors: Hassall CJ,Burnstock G

    更新日期:1987-09-29 00:00:00

  • Non-oriented cells of the striate cortex activated during smooth pursuit eye movements and steady fixations in behaving monkeys.

    abstract::Extracellular recordings were carried out in the primary visual cortex of behaving monkeys. Neurons were activated by moving a visual stimulus on their receptive fields during periods of steady fixation and by moving their receptive fields (smooth pursuit eye movements) on a motionless visual stimulus. Regarding non-o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90772-2

    authors: Galletti C,Squatrito S,Battaglini PP,Maioli MG

    更新日期:1983-01-31 00:00:00

  • Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes.

    abstract::Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospho-lipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer'...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146484

    authors: Nakajima S,Gotoh M,Fukasawa K,Murakami-Murofushi K,Kunugi H

    更新日期:2019-12-15 00:00:00

  • Effects of stimulating the dorsal raphe nucleus of the rat on neuronal activity in the dorsal lateral geniculate nucleus.

    abstract::The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90002-4

    authors: Kayama Y,Shimada S,Hishikawa Y,Ogawa T

    更新日期:1989-06-05 00:00:00

  • Progesterone stimulates sexual behaviour in female rats by increasing 5-HT activity on 5-HT2 receptors.

    abstract::We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91575-6

    authors: Wilson CA,Hunter AJ

    更新日期:1985-05-06 00:00:00

  • Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices.

    abstract::Mechanisms of neuronal death following neuronal damage due to domoic acid are not completely defined. Bcl-2, a survival protein, protects neurons from ischemia and excitotoxin-induced damage. We previously demonstrated that Bcl-2 shuttles calcineurin to its substrates and may regulate calcium release from internal sto...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.03.076

    authors: Erin N,Billingsley ML

    更新日期:2004-07-16 00:00:00

  • GABAergic ganglion cells in the rabbit retina.

    abstract::The ganglion cells are the output neurons of the retina. There is, however, relatively little known about the neurotransmitters used by these cells. In the present study, ganglion cells identified with a ganglion cell-specific monoclonal antibody (AB5) are shown in separate double-label experiments to be gamma-aminobu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91498-9

    authors: Yu BC,Watt CB,Lam DM,Fry KR

    更新日期:1988-01-26 00:00:00

  • Separation of different interictal discharge patterns in acute experimentally induced epileptic foci of the rat in vivo.

    abstract::Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular 1/s discharges, patterns with irregular discharges of about 0.5/s as well as compound patterns comprising di...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90221-8

    authors: Dorn T,Witte OW

    更新日期:1993-07-09 00:00:00

  • In vitro discrimination of the role of LRP1 at the BBB cellular level: focus on brain capillary endothelial cells and brain pericytes.

    abstract::Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.10.047

    authors: Candela P,Saint-Pol J,Kuntz M,Boucau MC,Lamartiniere Y,Gosselet F,Fenart L

    更新日期:2015-01-12 00:00:00

  • Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.

    abstract::Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02526-5

    authors: Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

    更新日期:2003-05-30 00:00:00

  • Synchronous firing dynamics in a heterogeneous neurosecretory-cell population in an insect.

    abstract::Five pairs of neurosecretory cells in the subesophageal ganglion of the silkmoth Bombyx mori discharge action potentials in (near) synchrony to release a pheromone biosynthesis-activating neuropeptide (PBAN). Waveforms of compound action potentials recorded extracellularly from axonal tracts were analyzed to determine...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03349-2

    authors: Ichikawa T

    更新日期:2002-03-08 00:00:00

  • Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning.

    abstract::The amygdala has long been implicated in conditioned fear. The mesencephalic dopaminergic system provides a rich innervation to the amygdala [J.H. Fallon, P. Ciofi, Distribution of monoamines within the amygdala, in: J.P. Aggleton (Ed.), The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01291-3

    authors: Guarraci FA,Frohardt RJ,Kapp BS

    更新日期:1999-05-08 00:00:00

  • Protein kinase C activation-induced increases of neural activity are enhanced in the hypothalamus of spontaneously hypertensive rats.

    abstract::We have previously reported that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these angiotensin II-sensitive neurons in the AHA are enhanced in spontaneously hypertensive rats (SHR). In addition, neural activations induced by bot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.11.029

    authors: Kubo T,Hagiwara Y

    更新日期:2005-02-08 00:00:00

  • Menstrual cycle phase modulates cognitive control over male but not female stimuli.

    abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.05.061

    authors: Roberts GM,Newell F,Simões-Franklin C,Garavan H

    更新日期:2008-08-11 00:00:00

  • Effect of steroid competition and time on the uptake of (3H)corticosterone in the rat brain; an autoradiographic study.

    abstract::The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90937-3

    authors: Rhees RW,Grosser BI,Stevens W

    更新日期:1975-01-10 00:00:00

  • Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus.

    abstract::The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. Electrically stimulated 5-HT efflux (10 pulses, 200 Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. Peak ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00289-8

    authors: Davidson C,Stamford JA

    更新日期:1997-06-20 00:00:00

  • Complementary mosaic distributions of thalamic and nigral axons in the caudate nucleus of the cat: double anterograde labeling combining autoradiography and wheat germ-HRP histochemistry.

    abstract::The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90287-2

    authors: Beckstead RM

    更新日期:1985-05-27 00:00:00

  • The paragigantocellular nucleus of the ventral medulla: a secondary source of cholinergic innervation of rat brainstem nuclei.

    abstract::Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90185-6

    authors: Sherriff FE,Henderson Z

    更新日期:1994-02-04 00:00:00

  • Epileptic and normal neurons in monkey neocortex: a quantitative study of degree of operant control.

    abstract::The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90884-3

    authors: Wyler AR,Finch CA,Burchiel KJ

    更新日期:1978-08-04 00:00:00

  • Long-term survival and development of dissociated parasympathetic neurons in culture.

    abstract::Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90127-4

    authors: Tuttle JB,Suszkiw JB,Ard M

    更新日期:1980-02-03 00:00:00

  • Effect of hypothyroidism on vasoactive intestinal polypeptide-immunoreactive neurons in forebrain-neurohypophysial nuclei of the rat brain.

    abstract::We have recently reported that hypothyroidism increases immunoreactive (IR)-vasoactive intestinal polypeptide (VIP) and VIP mRNA content in both parvocellular and magnocellular neurons of the rat, hypothalamic paraventricular nucleus (PVN). As VIP can stimulate vasopressin (AVP) secretion, we conducted an anatomical i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00340-v

    authors: Toni R,Mosca S,Ruggeri F,Valmori A,Orlandi G,Toni G,Lechan RM,Vezzadini P

    更新日期:1995-06-05 00:00:00

  • Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brain.

    abstract::Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01082-3

    authors: Kawamoto Y,Nakamura S,Kawamata T,Akiguchi I,Kimura J

    更新日期:1999-03-13 00:00:00

  • Immunocytochemical localization of glutamic acid decarboxylase (GAD) and glutamine synthetase (GS) in the area postrema of the cat. Light and electron microscopy.

    abstract::The present study was designed to investigate the existence of two key enzymes involved in the metabolism of gamma-aminobutyric acid, glutamic acid decarboxylase (GAD) and glutamine synthetase (GS), in the area postrema (AP) of the cat. The results showed that punctuate structures of variable size corresponding to axo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90320-9

    authors: D'Amelio FE,Mehler WR,Gibbs MA,Eng LF,Wu JY

    更新日期:1987-05-05 00:00:00