Reduction of [3H]muscimol binding sites in rat dorsal spinal cord after neonatal capsaicin treatment.

Abstract:

:Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]strychnine binding was unchanged. The results provide indirect evidence for a presynaptic location of GABA receptors on capsaicin-sensitive primary afferent neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Singer E,Placheta P

doi

10.1016/0006-8993(80)90160-2

subject

Has Abstract

pub_date

1980-12-08 00:00:00

pages

484-7

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(80)90160-2

journal_volume

202

pub_type

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