Abstract：
:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons controlling the excitability of surrounding neuropil. Thus, CO2 may represent an important, highly diffusible, signal in brain, involved in the tonic control of neuronal activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Agnati LF,Tinner B,Staines WA,Väänänen K,Fuxe Kdoi
10.1016/0006-8993(95)00026-msubject
Has Abstractpub_date
1995-04-03 00:00:00pages
10-24issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00026-Mjournal_volume
676pub_type
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