Abstract:
:Pituitary adenylate cyclase activating polypeptide (PACAP) is a hypothalamic peptide that affects anterior pituitary cell function. This study examined the effects of PACAP on prolactin (PRL) release in vivo and on tyrosine hydroxylase (TH) activity in tuberoinfundibular dopaminergic neurons in vivo and in vitro. In ovariectomized rats, intravenous injection of PACAP increased circulating PRL levels 3-fold and TH activity in the stalk-median eminence (SME) by 30%. Incubation of the SME with 1 microM PACAP in vitro increased TH activity 2-fold. Intravenous infusion of ovine PRL (oPRL) by an osmotic mini-pump for 2 days in ovariectomized rats increased TH activity in the SME 1.7-fold and reduced circulating concentrations of endogenous rat PRL to 20% of control levels. PACAP induced a 4-fold rise in endogenous rat PRL levels in oPRL-treated rats and a 30% increase in TH activity that was additive to the elevation caused by hyperprolactinemia. In suckled lactating rats, PACAP did not alter circulating PRL levels or TH activity in the SME. When pups were removed from the dams for 4-5 h, systemic injection of PACAP stimulated PRL release without altering TH activity. However, PACAP, when administered in vitro, stimulated TH activity in the SME of lactating rats separated from their pups. These data indicate that PACAP may play a role in augmenting PRL release in female rats. The PACAP-induced rise in PRL release is modest and not due to a decrease in tuberoinfundibular dopaminergic neuronal activity. PACAP increases TH activity in the tuberoinfundibular dopaminergic neurons, possibly by a direct action on nerve terminals within the median eminence.
journal_name
Brain Resjournal_title
Brain researchauthors
Arbogast LA,Voogt JLdoi
10.1016/0006-8993(94)91592-xsubject
Has Abstractpub_date
1994-08-29 00:00:00pages
17-24issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91592-Xjournal_volume
655pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::To verify whether microtubules are involved in the mechanism of axoplasmic transport in vivo, [3H]leucine was injected into ventral horns of rats, and 3 h later Ca2+ or other drugs injected into sciatic nerves. The injection of 50-200 mM Ca2+, raising intra-axoplasmic Ca2+ levels, blocked transport above the intraneur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90514-7
更新日期:1986-03-26 00:00:00
abstract::The aim of the present study was to determine differences in cortical processing of consonant-vowel syllables and acoustically matched non-speech sounds, as well as novel human and nonhuman sounds. Event-related potentials (ERPs) were recorded to vowel, vowel duration, consonant, syllable intensity, and frequency chan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.052
更新日期:2010-04-23 00:00:00
abstract::Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.036
更新日期:2013-02-01 00:00:00
abstract::A series of experiments were performed to study the effects of learning upon proteins in the split-brain pigeon. With this preparation, one side of the brain was trained in a color discrimination task while the other side served as a naive control. Proteins from both sides of the brain were separated by one- and two-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90349-2
更新日期:1980-09-29 00:00:00
abstract::Experiments were conducted to investigate whether or not reciprocal descending commands occur simultaneously in the brain as well as the phasic changes in the agonist facilitation and the antagonist inhibition involved in the initiation of varying forces of ankle dorsiflexion. The H-reflex and reaction time method wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91146-8
更新日期:1988-05-03 00:00:00
abstract::The expression of the calcium-binding protein calretinin (CR) in the chick cochlear nucleus, nucleus magnocellularis (NM), was examined after unilateral cochlea removal in hatchlings and 3-week-old birds. Following survival times of 3, 6 or 12 h or 1, 3 or 7 days, CR mRNA was localized by in situ hybridization using a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02476-8
更新日期:2000-08-04 00:00:00
abstract::Carnosine is a compound of naturally-occurring dipeptide that synthesized by the carnosine synthetase from beta-alanine and l-histidine. Recent reports claim that carnosine plays an important role in the control of epilepsy but its involvement in anticonvulsant functions remains unknown. In this study, we investigated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.019
更新日期:2008-11-06 00:00:00
abstract::The enzymatic and regulatory properties of Ca2+/calmodulin-dependent protein kinase in the postsynaptic density (mPSDp CaM kinase) of the rat forebrain was compared with those of soluble Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). mPSDp CaM kinase was different from soluble CaM kinase II in terms of s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91222-e
更新日期:1993-04-30 00:00:00
abstract::By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00557-7
更新日期:1995-09-04 00:00:00
abstract::Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91108-6
更新日期:1989-10-02 00:00:00
abstract::Daily changes in tryptophan-5-hydroxylase (TrH) activity have been studied in six different 5-HT-containing cell groups (B3, B4, B5, B6, B7, B8,) in the brain stem of rats maintained in a regular cycle of 12 h of light and 12 h of darkness. Significant circadian alternations of TrH activity were observed in most of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90647-3
更新日期:1977-03-04 00:00:00
abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.014
更新日期:2009-08-11 00:00:00
abstract::An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90615-6
更新日期:1976-03-12 00:00:00
abstract::Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons conta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90013-2
更新日期:1988-05-01 00:00:00
abstract::The spatial and temporal pattern of expression of the protein products of immediate early genes (IEGs) c-fos, fos B, and egr-1 were mapped in medial preoptic area (MPOA) and ventral bed nucleus of stria terminalis (VBST) during maternal behavior in rats. Immunocytochemical analysis indicated significant increases in t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00257-1
更新日期:1998-05-11 00:00:00
abstract::The ability of diphenylhydantoin (DPH) to protect against hypoxia-induced neuronal damage was examined using electrophysiological recordings of extracellular evoked potentials from CA1 pyramidal neurons of rat hippocampal slices in vitro. In normal medium, a 15-min hypoxic insult (95% N2/5% CO2) produced rapid and com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91501-q
更新日期:1991-04-19 00:00:00
abstract::Research supports the effectiveness of acupuncture for conditions such as chronic low back and knee pain. In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.004
更新日期:2011-09-26 00:00:00
abstract::The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global forebrain ischemia. Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension, and brain temperature maintained at either 37 degree...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90945-6
更新日期:1992-05-15 00:00:00
abstract::Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91197-x
更新日期:1980-01-27 00:00:00
abstract::Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.090
更新日期:2008-01-16 00:00:00
abstract::gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the present study we compared V(GAD) in cortex of control and vigabatrin-treate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02778-0
更新日期:2001-09-28 00:00:00
abstract::Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01222-0
更新日期:1999-01-23 00:00:00
abstract::The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91077-3
更新日期:1988-03-29 00:00:00
abstract::A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90512-6
更新日期:1994-12-30 00:00:00
abstract::In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02328-3
更新日期:2000-06-23 00:00:00
abstract::Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90271-n
更新日期:1993-08-20 00:00:00
abstract::A phosphorylated, approximately 110 kDa laminin-binding protein (110 kDa LBP) from mouse brain has been previously identified. This protein recognizes a neurite-outgrowth promoting 19-amino acid synthetic peptide (PA 22-2) derived from the laminin A chain. In the present study, an antibody against the 110 kDa LBP was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90356-z
更新日期:1991-08-02 00:00:00
abstract::Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91583-z
更新日期:1992-08-21 00:00:00
abstract::The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.04.045
更新日期:2010-06-25 00:00:00
abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90112-2
更新日期:1975-09-23 00:00:00