Enkephalin-immunoreactive fastigial neurons in the rat cerebellum project to upper cervical cord segments.

Abstract:

:By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant in other cerebellar nuclei. Enkephalin-immunoreactive fibers present in the ventral horn and the central cervical nucleus of upper cervical cord segments almost completely disappeared contralaterally following kainic acid-induced cell loss in the fastigial nucleus. The results indicate that fastigial and some other cerebellar nucleus neurons provide enkephalin-containing projections toward these spinal sites.

journal_name

Brain Res

journal_title

Brain research

authors

Ikeda M,Houtani T,Nakagawa H,Baba K,Kondoh A,Ueyama T,Yamamoto T,Gemba H,Sugimoto T

doi

10.1016/0006-8993(95)00557-7

subject

Has Abstract

pub_date

1995-09-04 00:00:00

pages

225-30

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00557-7

journal_volume

690

pub_type

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