Abstract：
:Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.
journal_name
Brain Resjournal_title
Brain researchauthors
Smith CC,Bowen DM,Sims NR,Neary D,Davison ANdoi
10.1016/0006-8993(83)91131-9subject
Has Abstractpub_date
1983-03-28 00:00:00pages
138-41issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)91131-9journal_volume
264pub_type
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