Abstract：
:Axotomy of cholinergic neurons in the medial septum-diagonal band and degeneration of their terminals in the hippocampus resulting from fornix-fimbria lesions induce elevation of NGF content in these two brain regions. Postlesion levels of cholinergic neuron-specific ChAT activity in the septum suggest that endogenously produced NGF may, at least partly, promote survival of axotomized cholinergic neurons or induce ChAT activity in undamaged cells or both. These findings thus support the proposed trophic role for NGF in central cholinergic neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Gasser UE,Weskamp G,Otten U,Dravid ARdoi
10.1016/0006-8993(86)90198-8subject
Has Abstractpub_date
1986-06-25 00:00:00pages
351-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90198-8journal_volume
376pub_type
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