Involvement of M1 muscarinic receptors in the initiation of cholinergically induced epileptic seizures in the rat brain.

abstract：BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...

journal_title：Brain research

authors： Lukic-Panin V,Kamiya T,Zhang H,Hayashi T,Tsuchiya A,Sehara Y,Deguchi K,Yamashita T,Abe K

更新日期：2007-10-24 00:00:00

abstract：:Light stimulates dopamine (DA) release in the retina. The purpose of this study was to determine the threshold and dose-response relationship between ocular light exposure and retinal DA synthesis in vivo. Groups of dark-adapted rats were exposed to 0, 1, 3, 5, 10, 25, 50, 100 or 1000 microwatts per square centimeter ...

journal_title：Brain research

authors： Brainard GC,Morgan WW

更新日期：1987-10-20 00:00:00

abstract：:The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...

journal_title：Brain research

authors： Moller K,Reimer M,Ekblad E,Hannibal J,Fahrenkrug J,Kanje M,Sundler F

更新日期：1997-11-14 00:00:00

abstract：:Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...

journal_title：Brain research

authors： Cannizzaro C,Martire M,Cannizzaro E,Provenzano G,Gagliano M,Carollo A,Mineo A,Steardo L

更新日期：2001-06-22 00:00:00

abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...

journal_title：Brain research

authors： Wolf DH,Nestler EJ,Russell DS

更新日期：2007-07-02 00:00:00

abstract：:The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...

journal_title：Brain research

authors： Poling KR,Brunjes PC

更新日期：2000-02-21 00:00:00

abstract：:In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...

journal_title：Brain research

authors： Mehta AK,Ticku MK

更新日期：1998-09-14 00:00:00

abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...

journal_title：Brain research

authors： Buchanan JA,Bilkey DK

更新日期：1997-10-10 00:00:00

abstract：:This study addressed the issue of multiple parallel auditory processing systems and their relationship to the skull-recorded auditory evoked potentials (AEPs) in the unanesthetized, unrestrained rat. In the preceding paper (Brain Res., 602 (1993) 240-250) it has been shown that auditory cortex activity does not contri...

journal_title：Brain research

authors： Simpson GV,Knight RT

更新日期：1993-02-05 00:00:00

abstract：:Immunohistochemical studies have suggested that corticotropin-releasing factor (CRF) was a transmitter of the olivocerebellar projection. We used in situ hybridization histochemistry with a 35S-labeled oligodeoxyribonucleotide probe for CRF mRNA to show that inferior olivary neurons of rats, baboons, and humans synthe...

journal_title：Brain research

authors： Young WS 3rd,Walker LC,Powers RE,De Souza EB,Price DL

更新日期：1986-11-01 00:00:00

abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...

journal_title：Brain research

authors： Galvez R,Gopal AR,Greenough WT

更新日期：2003-05-02 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, ...

journal_title：Brain research

authors： Mulugeta E,Karlsson E,Islam A,Kalaria R,Mangat H,Winblad B,Adem A

更新日期：2003-01-17 00:00:00

abstract：:The medial preoptic nucleus (MPN) of the medial preoptic area (MPOA) and the medial amygdala are two brain regions in which male rat sexual behavior increased Fos-like immunoreactivity (Fos-Li). Dopamine is released in the MPOA during male rat sexual behavior and facilitates copulation. Psychostimulants, which increas...

journal_title：Brain research

authors： Lumley LA,Hull EM

更新日期：1999-05-22 00:00:00

abstract：:The study examined whether intravenous (i.v.) leptin increased Fos-production in spinally projecting neurons in the hypothalamic paraventricular nucleus (PVN). We combined (i) rhodamine tagged microspheres injected into the upper thoracic spinal cord and (ii) Fos (marker of neuronal activation) immunohistochemistry. E...

journal_title：Brain research

authors： Badoer E,Ryan A

更新日期：1999-10-09 00:00:00

abstract：:In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...

journal_title：Brain research

authors： Wenthold RJ,McGarvey ML

更新日期：1982-12-16 00:00:00

abstract：:To characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (AAS; 14 daily injections of...

journal_title：Brain research

authors： Menard CS,Harlan RE

更新日期：1993-09-17 00:00:00

abstract：:To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong G...

journal_title：Brain research

authors： Visser DT,Hu Z,Pasterkamp RJ,Morimoto M,Kawata M

更新日期：1996-08-12 00:00:00

abstract：:The activity of 294 single units was recorded from the dorsolateral prefrontal cortex of monkeys performing two visual discrimination tasks with delayed response. One task, delayed matching-to-sample (DMS), required memory of a colored cue for later (18 s) matching and choice of color; the cue did not connote the loca...

journal_title：Brain research

authors： Quintana J,Yajeya J,Fuster JM

更新日期：1988-12-06 00:00:00

abstract：:Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. The experiments reported here demonstrate that cocaine blocks the induction of LTP at the excitatory synapses in the CA1 region of the hippocampus, but does not appear to do so by blocking NMDA receptors or channels. O...

journal_title：Brain research

authors： Smith DA,Browning M,Dunwiddie TV

更新日期：1993-04-16 00:00:00

abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...

journal_title：Brain research

authors： Torres-Pérez M,Rosillo JC,Berrosteguieta I,Olivera-Bravo S,Casanova G,García-Verdugo JM,Fernández AS

更新日期：2017-10-15 00:00:00

abstract：:This study examines the role of catecholamines, cell bodies and fibers of passage within the subcoeruleus area (subLC) in the arginine vasopressin (AVP) response to splanchnic osmotic stimulation and hemorrhage. Bilateral chemical lesions were induced into the subLC, approximately 1 mm ventral to the locus coeruleus (...

journal_title：Brain research

authors： King MS,Baertschi AJ

更新日期：1992-05-15 00:00:00

abstract：:Extracellular recordings were made in vitro from 212 single units in the rat subfornical organ (SFO) and 54 single units in the rat medial preoptic area (MPO). Units were exposed to solutions made hyper-osmotic or hypo-osmotic by 1.4-11%. A reversible 30% or greater change in frequency followed the osmotic challenge i...

journal_title：Brain research

authors： Sibbald JR,Hubbard JI,Sirett NE

更新日期：1988-10-04 00:00:00

abstract：:An in vitro radioenzymatic assay and purification procedure by thin-layer chromatography were used to study the metabolism of dihydrotestosterone (DHT) into 3 alpha- and 3 beta-androstanediols by the brain and cloacal gland of Japanese quail. Kinetic studies showed that these 2 metabolites are produced in a linear fas...

journal_title：Brain research

authors： Deviche P,Delville Y,Balthazart J

更新日期：1987-09-22 00:00:00

abstract：:Activation of phospholipase C (PLC) coupled to phosphoinositide (PtdIns) hydrolysis occurs through one of the two pathways. One of the major pathways for the neurotransmitter signaling involves phosphoinositide (PtdIns) specific and G-protein dependent PLC-beta, which stimulates the formation of inositol triphosphate ...

journal_title：Brain research

authors： Narang N,Joseph JA,Ayyagari PV,Gerber M,Crews FT

更新日期：1996-02-05 00:00:00

abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...

journal_title：Brain research

authors： Amir S,Meyerovitch J,Shechter Y

更新日期：1987-09-01 00:00:00

abstract：:Monoclonal antibody N1 reacts by indirect immunofluorescence with the cell surface of tetanus toxin-positive neurons from early postnatal mouse cerebellum. In freshly trypsinized single cell suspensions from early postnatal mouse cerebellum, 5-10% of all viable cells express N1 antigen on their surface. After 3-24 h o...

journal_title：Brain research

authors： Schnitzer J,Kim SU,Schachner M

更新日期：1984-07-01 00:00:00

abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

journal_title：Brain research

authors： Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

更新日期：2003-05-30 00:00:00

abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...

journal_title：Brain research

authors： Delwing D,Bavaresco CS,Chiarani F,Wannmacher CM,Wajner M,Dutra-Filho CS,de Souza Wyse AT

更新日期：2003-11-21 00:00:00

abstract：:The technique of intracranial microdialysis was used to investigate the effects of aging on the striatal dopaminergic system of the anesthetized Fischer 344 rat. Microdialysis probes were implanted into the striatum of young (2-8 months) and aged (24-28 months) urethane anesthetized rats. Striatal dialysate levels wer...

journal_title：Brain research

authors： Gerhardt GA,Maloney RE Jr

更新日期：1999-01-16 00:00:00