Abstract：
:The present study investigates the effects of gammavinylgaba (GVG, 4 days treatment at 50 and 200 mg/kg), a gabatransaminase inhibitor, on the high-voltage spindle (HVS) activity in control and nucleus basalis-lesioned rats. GVG treatment at 200 mg/kg, but not at 50 mg/kg increased HVS activity in controls. GVG greatly aggravated nucleus basalis magnocellularis (NBM) lesion-induced increase in HVS activity at 200 mg/kg, but not at 50 mg/kg. The present results demonstrate that partial NBM lesions increase the HVS inducing potency of GVG.
journal_name
Brain Resjournal_title
Brain researchauthors
Riekkinen P Jr,Sirviö J,Riekkinen M,Valjakka A,Koivisto E,Riekkinen Pdoi
10.1016/0006-8993(91)91667-psubject
Has Abstractpub_date
1991-11-29 00:00:00pages
341-4issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91667-Pjournal_volume
565pub_type
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