Chronic haloperidol inactivates brain noradrenergic neurons.

abstract：:Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...

journal_title：Brain research

authors： Yan H,Chen Y,Li L,Jiang J,Wu G,Zuo Y,Zhang JH,Feng H,Yan X,Liu F

更新日期：2016-01-01 00:00:00

abstract：:Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino a...

journal_title：Brain research

authors： Lehmann A,Hagberg H,Jacobson I,Hamberger A

更新日期：1985-12-16 00:00:00

abstract：:The effects of repeated, once daily exposure to either restraint or tail pinch stress on extracellular levels of dopamine in nucleus accumbens and striatum were electrochemically monitored in conscious rats using high-speed chronoamperometry. Acutely, both tail pinch and restraint increased extracellular dopamine leve...

journal_title：Brain research

authors： Doherty MD,Gratton A

更新日期：1992-07-24 00:00:00

abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...

journal_title：Brain research

authors： Dunn JP,Cowan RL,Volkow ND,Feurer ID,Li R,Williams DB,Kessler RM,Abumrad NN

更新日期：2010-09-02 00:00:00

abstract：:The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...

journal_title：Brain research

authors： Katayama Y,Kiyama H,Arai Y,Tohyama M

更新日期：1984-09-17 00:00:00

abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...

journal_title：Brain research

authors： Saint Marie RL,Stanforth DA,Jubelier EM

更新日期：1997-08-08 00:00:00

abstract：:Microinjection of the indirect GABAA antagonist, picrotoxin, or the mu opioid agonist, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO), into the ventral pallidum and substantia innominata (VP/SI) increases locomotor activity in rats. The VP/SI has direct and indirect projections to the region of the ventral mesencephalon containi...

journal_title：Brain research

authors： Austin MC,Kalivas PW

更新日期：1991-02-22 00:00:00

abstract：:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...

journal_title：Brain research

authors： Palovcik RA,Phillips MI,Kappy MS,Raizada MK

更新日期：1984-08-20 00:00:00

abstract：:This research examined the electrophysiological, behavioral and neuroanatomical changes following an injection of kainic acid (KA) which destroyed most of the CA3 pyramidal cells in the hippocampus. For 5 days following the injection of KA, the evoked potential (EP) in the CA1 pyramidal cells produced by stimulation o...

journal_title：Brain research

authors： Fowler KR,Olton DS

更新日期：1984-10-29 00:00:00

abstract：:The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articul...

journal_title：Brain research

authors： Zhang WS,Xu H,Xu B,Sun S,Deng XM,Zhang YQ

更新日期：2009-04-06 00:00:00

abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...

journal_title：Brain research

authors： Rogatsky GG,Kamenir Y,Mayevsky A

更新日期：2005-06-21 00:00:00

abstract：:Nerve growth factor (NGF) treatment, given as a single 200 BU intraocular injection at the time of optic nerve transection, was found to significantly accelerate the retinal ganglion cell response to axotomy in the newt (Notophthalmus viridescens). In the control series the per cent of neurons in the retinal ganglion ...

journal_title：Brain research

authors： Turner JE,Delaney RK

更新日期：1979-08-03 00:00:00

abstract：:Cultures of neonatal mouse cortical astrocytes synthesized NGF mRNA and released immunoreactive NGF (ir-NGF) into the culture medium. Addition of 10 microM guanosine or GTP to the cultures increased ir-NGF release by 6 and 2 fold, respectively, after 24 h, and increased NGF mRNA 6 fold after 4 h and 2-3 fold after 24 ...

journal_title：Brain research

authors： Middlemiss PJ,Gysbers JW,Rathbone MP

更新日期：1995-04-17 00:00:00

abstract：:The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...

journal_title：Brain research

authors： Dudley CA,Moss RL

更新日期：1994-04-11 00:00:00

abstract：:Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...

journal_title：Brain research

authors： Kingston PA,Crews D

更新日期：1994-04-18 00:00:00

abstract：:Previous studies have shown that pyramidal neurons in hippocampal regions CA1 and CA3 are selectively vulnerable in several neurodegenerative disorders and that a subpopulation of pyramidal neurons in cell cultures of embryonic hippocampus are sensitive to glutamate neurotoxicity. In order to determine whether the pat...

journal_title：Brain research

authors： Mattson MP,Kater SB

更新日期：1989-06-19 00:00:00

abstract：:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...

journal_title：Brain research

authors： Dihné M,Block F

更新日期：2001-01-19 00:00:00

abstract：:We previously reported that brain angiotensin II type 2 (AT2) receptors contribute to the hyperthermia induced by intrahypothalamic (intrapreoptic (i.p.o.)) administration of prostaglandin E2 (PGE2) in rats. The present study was carried out to investigate the role of angiotensin II (ANG II) receptors in the cardiovas...

journal_title：Brain research

authors： Watanabe T,Sakata Y,Wada M

更新日期：2000-01-03 00:00:00

abstract：:Small iontophoretic application of wheat-germ-agglutinin conjugated to horseradish peroxidase, was used to simultaneously observe, in the rat, the afferent and the efferent connections of the cuneiformis nucleus (Cnf), in the same animal. The results demonstrate that the main Cnf afferent connections originate from: (...

journal_title：Brain research

authors： Bernard JF,Peschanski M,Besson JM

更新日期：1989-06-19 00:00:00

abstract：:Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were ana...

journal_title：Brain research

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Konopacki J

更新日期：2017-11-15 00:00:00

abstract：:The monoamine levels in the locus coeruleus (LC) were determined by HPLC following specific lesions of the ventral mesencephalic tegmental-A10 regions (VMT-A10) and raphé dorsalis (RD). Only lesions in the VMT-A10 area decreased the dopamine (DA) content, which strongly suggests that the projection from this region to...

journal_title：Brain research

authors： McRae-Degueurce A,Milon H

更新日期：1983-03-21 00:00:00

abstract：:We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...

journal_title：Brain research

authors： Averill DB,Tsuchihashi T,Khosla MC,Ferrario CM

更新日期：1994-12-05 00:00:00

abstract：:As measured by extracellular single-cell recording, the responses to adenosine triphosphate (ATP) by ATP-sensitive chemoreceptors (ATP cells) on the olfactory organ of the spiny lobster are markedly suppressed by adenosine diphosphate (ADP), adenosine monophosphate (AMP) and to a lesser extent, adenosine, when each is...

journal_title：Brain research

authors： Gleeson RA,Carr WE,Trapido-Rosenthal HG

更新日期：1989-09-11 00:00:00

abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...

journal_title：Brain research

authors： Weerasuriya A,Rapoport SI,Taylor RE

更新日期：1979-09-21 00:00:00

abstract：:We examined the effects of early epileptiform activity on development of visuocortical receptive fields in the rabbit. Aqueous penicillin was injected twice a day into a cannula implanted over the monocular area of one visual cortex. Drug administration was begun on postnatal day 8-9 and continued until postnatal day ...

journal_title：Brain research

authors： Crabtree JW,Chow KL,Ostrach LH,Baumbach HD

更新日期：1981-04-01 00:00:00

abstract：:The effects of divalent and trivalent cations on the gamma-aminobutyric acid (GABA)-induced chloride current were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell configuration of the patch-clamp technique. Lanthanum (La3+) reversibly potentiated the GABA-induced current with a hal...

journal_title：Brain research

authors： Ma JY,Narahashi T

更新日期：1993-04-02 00:00:00

abstract：:The mechanism of the antinociceptive effect of the tricyclic antidepressant imipramine was investigated in mice. Intrathecal (i.t.) administration of imipramine produced dose-dependent antinociception in the tail-pinch and tail-flick tests with ED50 values (95% confidence limit) of 27.5 (17.0-43.9) and 20.2 (12.6-32.2...

journal_title：Brain research

authors： Iwashita T,Shimizu T

更新日期：1992-05-22 00:00:00

abstract：:A pair of adult molluscan neurons (L5 and R5) are known to sprout and form a new electrical synapse following axotomy. Additionally, certain forms of stress can elicit restricted sprouting of neurons L5 and R5 within the intact nervous system. This study found that the strength of 5-5 electrical coupling was increased...

journal_title：Brain research

authors： Bulloch AG

更新日期：1985-09-23 00:00:00

abstract：:Daily changes in tryptophan-5-hydroxylase (TrH) activity have been studied in six different 5-HT-containing cell groups (B3, B4, B5, B6, B7, B8,) in the brain stem of rats maintained in a regular cycle of 12 h of light and 12 h of darkness. Significant circadian alternations of TrH activity were observed in most of th...

journal_title：Brain research

authors： Kan JP,Chouvet G,Hery F,Debilly G,Mermet A,Glowinski J,Pujol JF

更新日期：1977-03-04 00:00:00

abstract：:We measured soleus H-reflex in the Sprague-Dawley rat as a function of time of day. H-reflex amplitude displayed a marked diurnal variation, even though background EMG and M-response amplitude were stable through the day. The H-reflex was largest in the late morning and smallest around midnight. Thus, its rhythm was o...

journal_title：Brain research

authors： Chen XY,Wolpaw JR

更新日期：1994-06-13 00:00:00