Abstract：
:Synaptosomes assemble an equatorial coil of microtubules during incubation at 37 degrees C. Stimulation of synaptosomes by veratridine or A23187 for 5 min results in disassembly of the microtubules. The role of microtubule disassembly in neurotransmitter release was investigated using the microtubule-stabilizing drug taxol. Taxol stimulates microtubule assembly in synaptosomes and prevents microtubule disassembly caused by A23187. However, taxol has no effect on the release of [3H]acetylcholine triggered by veratridine or A23187. These results suggest that microtubule turnover is not necessary for neurotransmitter release.
journal_name
Brain Resjournal_title
Brain researchauthors
Burgoyne RD,Cumming Rdoi
10.1016/0006-8993(83)91192-7subject
Has Abstractpub_date
1983-11-28 00:00:00pages
190-3issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)91192-7journal_volume
280pub_type
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