Effect of oxotremorine on local cerebral glucose utilization in motor system regions of the rat brain.

abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...

journal_title：Brain research

authors： Zalcman S,Shanks N,Anisman H

更新日期：1991-08-23 00:00:00

abstract：:Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...

journal_title：Brain research

authors： Hester S,Capps-Covey P,McIlwain DL

更新日期：1978-12-22 00:00:00

abstract：:Glial-derived monocarboxylate lactate is thought to be an important energy source for neurons during brain activation or in hypoxia-ischemia. Treatment with alpha-cyano-4-hydroxycinnamate (4-CIN), a monocarboxylate transporter inhibitor, has been recently reported to exacerbate delayed neuronal damage in a rat model o...

journal_title：Brain research

authors： Melena J,Safa R,Graham M,Casson RJ,Osborne NN

更新日期：2003-10-31 00:00:00

abstract：:The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...

journal_title：Brain research

authors： Maeda T,Cheng N,Kume T,Kaneko S,Kouchiyama H,Akaike A,Ueda M,Satoh M,Goshima Y,Misu Y

更新日期：1997-10-10 00:00:00

abstract：:To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...

journal_title：Brain research

authors： Kow LM,Weesner GD,Pfaff DW

更新日期：1992-08-21 00:00:00

abstract：:Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...

journal_title：Brain research

authors： Aiko Y,Shima F,Hosokawa S,Kato M,Kitamura K

更新日期：1987-04-07 00:00:00

abstract：:When observing bistable stimuli, the percept can change in the absence of changes in the stimulus itself. When intermittently presenting a bistable stimulus, the number of perceptual alternations can increase or decrease, depending on the duration of the period that the stimulus is removed from screen between stimulus...

journal_title：Brain research

authors： Raemaekers M,van der Schaaf ME,van Ee R,van Wezel RJ

更新日期：2009-02-03 00:00:00

abstract：:Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...

journal_title：Brain research

authors： Vandermaelen CP,Aghajanian GK

更新日期：1982-05-06 00:00:00

abstract：:Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quin...

journal_title：Brain research

authors： He L,Di Monte DA,Langston JW,Quik M

更新日期：2000-12-01 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...

journal_title：Brain research

authors： He XL,Zhou WQ,Bi MG,Du GH

更新日期：2010-06-02 00:00:00

abstract：:In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...

journal_title：Brain research

authors： Takahashi O,Traub RJ,Ruda MA

更新日期：1988-12-13 00:00:00

abstract：:'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedbac...

journal_title：Brain research

authors： Wang C,Huang JY,Bardy C,FitzGibbon T,Dreher B

更新日期：2010-04-30 00:00:00

abstract：:The aim of this study was to describe the normal distribution of the water content in several regions of the rat brain and furthermore to determine if global ischemia results in a variable increase in water content in these regions. Water content was determined in 40 regions; in 8 unaffected brains by gravimetry and i...

journal_title：Brain research

authors： Schwab M,Bauer R,Zwiener U

更新日期：1997-02-21 00:00:00

abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...

journal_title：Brain research

authors： Steimer T,Hutchison JB

更新日期：1989-02-20 00:00:00

abstract：:The malformative cortical lesions in the cerebral cortex that are characteristic of focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Increasing evidence suggests that extracellular matrix molecules play important rol...

journal_title：Brain research

authors： Li S,Yu S,Zhang C,Shu H,Liu S,An N,Yang M,Yin Q,Yang H

更新日期：2012-05-09 00:00:00

abstract：:Hippocampal slices prepared from adult rats were loaded with fura-2 and the intracellular free Ca2+ concentration ([Ca2+]i) in the CA1 pyramidal cell layer was measured. Hypoxia (oxygen-glucose deprivation) elicited a gradual increase in [Ca2+]i in normal Krebs solution. At high extracellular sodium concentrations ([N...

journal_title：Brain research

authors： Yamaguchi S,Endo K,Kitajima T,Ogata H,Hori Y

更新日期：1998-12-07 00:00:00

abstract：:Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...

journal_title：Brain research

authors： McCloskey DP,Adamo DS,Anderson BJ

更新日期：2001-02-09 00:00:00

abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...

journal_title：Brain research

authors： Vanĕcek J,Vollrath L

更新日期：1989-12-25 00:00:00

abstract：:The pedunculopontine nucleus (PPN) located in the mesopontine tegmentum is innervated by descending projections from nuclei in the basal ganglia. The present study was performed to determine whether nigrostriatal dopaminergic neuron degeneration is associated with changes in PPN metabolic activity. Unilateral nigrostr...

journal_title：Brain research

authors： Carlson JD,Pearlstein RD,Buchholz J,Iacono RP,Maeda G

更新日期：1999-05-15 00:00:00

abstract：:The influence of the superficial layers of the superior colliculus (SC) on responses of the lateral geniculate nucleus was studied in anesthetized and paralyzed rabbits. Fifty to one hundred nanoliters of inactivating drugs were injected through a micropipette positioned in the SC in register with the geniculate cells...

journal_title：Brain research

authors： Molotchnikoff S,Delaunais D,Casanova C,Lachapelle P

更新日期：1986-06-04 00:00:00

abstract：:The effects of baclofen microinjected into the nucleus tractus solitarii (NTS) on blood pressure, heart rate and baroreflex bradycardia were studied in urethane-anesthetized rats. Baclofen caused dose-dependent pressor and tachycardic effects and inhibited the reflex bradycardia elicited by i.v. phenylephrine. The eff...

journal_title：Brain research

authors： Florentino A,Varga K,Kunos G

更新日期：1990-12-10 00:00:00

abstract：:Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...

journal_title：Brain research

authors： Rashad S,Niizuma K,Sato-Maeda M,Fujimura M,Mansour A,Endo H,Ikawa S,Tominaga T

更新日期：2018-11-15 00:00:00

abstract：:Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...

journal_title：Brain research

authors： Lucius R,Sievers J

更新日期：1996-12-16 00:00:00

abstract：:The projection from the vestibular and perihypoglossal nuclei to the spinal trigeminal and lateral reticular nuclei has been studied in cats where the wheat germ agglutinin-horseradish peroxidase complex has been used as a retrograde tracer. All injections were made at the level of the caudal pole of the inferior oliv...

journal_title：Brain research

authors： Walberg F,Dietrichs E,Nordby T

更新日期：1985-04-29 00:00:00

abstract：:Recently, the gene encoding the cerebrovascular and neuritic plaque amyloid, a pathologic stigma of Alzheimer's disease (AD), has been molecularly cloned and mapped to human chromosome 21, band q21. Changes in the brains of individuals with trisomy 21 (Down syndrome, DS) over 35 years of age closely resemble AD neurop...

journal_title：Brain research

authors： Reeves RH,Robakis NK,Oster-Granite ML,Wisniewski HM,Coyle JT,Gearhart JD

更新日期：1987-09-01 00:00:00

abstract：:The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its putative toxic metabolite 1-methyl-4-phenylpyridinium ion MPP+ were studied with specific neuronal and glial cell lines in vitro. MPTP had no morphological effect on actively growing neuroblastoma N2AB-1 cells or C6 glioma cells nor did it affe...

journal_title：Brain research

authors： Notter MF,Irwin I,Langston JW,Gash DM

更新日期：1988-07-26 00:00:00

abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...

journal_title：Brain research

authors： Zaiser AE,Miletic V

更新日期：2000-09-08 00:00:00

abstract：:High-resolution positron emission tomography (microPET) allows for repeated observations of brain function in the same animal. In a previous study, using [(18)F] fluorodeoxyglucose (FDG) microPET, we demonstrated diminished glucose metabolism and subsequent recovery in the Neostriatum and thalamus ipsilateral to corti...

journal_title：Brain research

authors： Mir HM,Tatsukawa KJ,Carmichael ST,Chesselet MF,Kornblum HI

更新日期：2004-03-26 00:00:00

abstract：:In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...

journal_title：Brain research

authors： Hatip-Al-Khatib I,Mishima K,Iwasaki K,Fujiwara M

更新日期：2001-05-25 00:00:00

abstract：:In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...

journal_title：Brain research

authors： Britt RH

更新日期：1976-08-13 00:00:00