Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.

abstract：:DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...

journal_title：Brain research

authors： Eriksson P,Ahlbom J,Fredriksson A

更新日期：1992-06-12 00:00:00

abstract：:Two categories of large neurons--fusiform cells and giant cells--can be distinguished in the dorsal cochlear nucleus of the hamster. In the adult, these neurons are located in separate laminae in the nucleus and have distinct dendritic morphology. However, the two cell types are not distinguishable in the newborn hams...

journal_title：Brain research

authors： Schweitzer L,Cant NB

更新日期：1985-05-01 00:00:00

abstract：:Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...

journal_title：Brain research

authors： Beaulieu M,Coyle JT

更新日期：1982-08-01 00:00:00

abstract：:Explosive running is a reliable initial component of audiogenic seizures (AS) induced by acoustic stimulation in genetically prone rodents. This profound locomotor activation is usually considered as a convulsive manifestation of AS although some studies attribute running to a panic-like response. Increase in central ...

journal_title：Brain research

authors： Vinogradova LV,Shatskova AB,Tuomisto L

更新日期：2007-05-07 00:00:00

abstract：:This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...

journal_title：Brain research

authors： Sarrieau A,Dussaillant M,Sapolsky RM,Aitken DH,Olivier A,Lal S,Rostène WH,Quirion R,Meaney MJ

更新日期：1988-02-23 00:00:00

abstract：:This study evaluated the effect of stress during puberty on sexual motivation and the correlation between serum testosterone levels (T) and the absolute power of the theta electroencephalographic rhythms, recorded in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) of adult male rats. Thirty males of...

journal_title：Brain research

authors： Hernández-Arteaga E,Hernández-González M,Bonilla-Jaime H,Guevara MA,Ågmo A

更新日期：2020-10-15 00:00:00

abstract：:Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...

journal_title：Brain research

authors： Furuichi Y,Katsuta K,Maeda M,Ueyama N,Moriguchi A,Matsuoka N,Goto T,Yanagihara T

更新日期：2003-03-07 00:00:00

abstract：:We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...

journal_title：Brain research

authors： Shin C,Rigsbee LC,McNamara JO

更新日期：1986-11-29 00:00:00

abstract：:The effect of maternal hyperthermia on the developmental state of newborn guinea pig brains has been studied. Mean litter size and mean body weights of young from control and experimental mothers did not differ. Mean brain weight of young from control mothers (2.72 +/- 0.02 g) was larger than that from experimental mo...

journal_title：Brain research

authors： Hutchinson R,Bowler K

更新日期：1984-06-01 00:00:00

abstract：:The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...

journal_title：Brain research

authors： Booth RG,Baldessarini RJ

更新日期：1991-08-23 00:00:00

abstract：:We have shown that, when an amyloid-beta peptide (Abeta) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Abeta pathology associated with decreased amyloidogenic processing of amyloid precursor protein (APP) and...

journal_title：Brain research

authors： Todd Roach J,Volmar CH,Dwivedi S,Town T,Crescentini R,Crawford F,Tan J,Mullan M

更新日期：2004-07-23 00:00:00

abstract：:Synaptic glomeruli in the nucleus submedius of the rat are described and the source of some of the component terminals identified. The glomeruli consist of large terminals with round synaptic vesicles establishing Gray type I contacts with dendrites and surrounded by layers of astrocyte derived membranes. The astrocyt...

journal_title：Brain research

authors： Ma W,Ohara PT

更新日期：1987-07-14 00:00:00

abstract：:Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic n...

journal_title：Brain research

authors： Choi S,Blake V,Cole S,Fernstrom JD

更新日期：2006-05-04 00:00:00

abstract：:We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...

journal_title：Brain research

authors： Horii A,Nakagawa A,Uno A,Kitahara T,Imai T,Nishiike S,Takeda N,Inohara H

更新日期：2012-01-30 00:00:00

abstract：:A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of ...

journal_title：Brain research

authors： Wu D,Lv P,Li F,Zhang W,Fu G,Dai J,Hu N,Liu J,Xiao Y,Li S,Shah C,Tao B,Zhao Y,Gong Q,Lui S

更新日期：2019-12-01 00:00:00

abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...

journal_title：Brain research

authors： Advokat C,McInnis C

更新日期：1992-05-22 00:00:00

abstract：:The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...

journal_title：Brain research

authors： Kogure K,Alonso OF,Martinez E

更新日期：1980-08-11 00:00:00

abstract：:The effects of duloxetine were examined on cloned Kv4.3 channels stably expressed in CHO cells using the whole-cell patch-clamp technique. Duloxetine decreased the peak amplitude of Kv4.3 currents with an acceleration of the decay rate of current inactivation in a concentration-dependent manner. The IC(50) values requ...

journal_title：Brain research

authors： Choi JS,Hahn SJ

更新日期：2012-07-23 00:00:00

abstract：:The peak-to-peak amplitude of temporal middle latency response (MLR) of the guinea pig, evoked by a click in the contralateral ear, according to the recording side, is increased with the presence of continuous white noise (CWN) in the ipsilateral ear and this specialty is defined as the white noise enhancement (WNE). ...

journal_title：Brain research

authors： Goksoy C,Demirtas S,Ungan P

更新日期：2004-08-13 00:00:00

abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...

journal_title：Brain research

authors： Kuo H,Ingram DK,Crystal RG,Mastrangeli A

更新日期：1995-12-24 00:00:00

abstract：:In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...

journal_title：Brain research

authors： Segu L,Calas A

更新日期：1978-09-29 00:00:00

abstract：:This study examines the role of catecholamines, cell bodies and fibers of passage within the subcoeruleus area (subLC) in the arginine vasopressin (AVP) response to splanchnic osmotic stimulation and hemorrhage. Bilateral chemical lesions were induced into the subLC, approximately 1 mm ventral to the locus coeruleus (...

journal_title：Brain research

authors： King MS,Baertschi AJ

更新日期：1992-05-15 00:00:00

abstract：:There is an abundance of evidence suggesting that the area postrema (AP) is involved in the central actions of arginine-vasopressin (AVP) and angiotensin II (Ang II) on cardiovascular regulation. Furthermore, recent studies have shown that activation of the AP facilitates the response of nucleus tractus solitarius (NT...

journal_title：Brain research

authors： Cai Y,Hay M,Bishop VS

更新日期：1994-06-06 00:00:00

abstract：:Short-term potentiation of extracellular field excitatory postsynaptic potentials (EPSP's) was investigated in the stratum radiatum of CA1 of the rat hippocampal slice in vitro. A presynaptic tetanus consisting of a single train of stimuli at 250 Hz evoked short-term potentiation (STP), but not long-term potentiation ...

journal_title：Brain research

authors： Anwyl R,Lee WL,Rowan M

更新日期：1988-08-30 00:00:00

abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....

journal_title：Brain research

authors： Sharma SC,Jadhao AG,Rao PD

更新日期：1993-08-27 00:00:00

abstract：:The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...

journal_title：Brain research

authors： Markham JA,Fifková E

更新日期：1986-06-01 00:00:00

abstract：:Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 mic...

journal_title：Brain research

authors： Pearl SM,Herrick-Davis K,Teitler M,Glick SD

更新日期：1995-03-27 00:00:00

abstract：:Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subs...

journal_title：Brain research

authors： Patel R,Sesti F

更新日期：2016-05-15 00:00:00

abstract：:The ability of membrane-associated peptidases from the brains of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats to metabolize iodinated angiotensin (125I-Ang II) and 125I-Ang III was compared. 125I-Ang II was metabolized to 125I-Ang III and other fragments exclusively by membrane-assoc...

journal_title：Brain research

authors： Cook VI,Wright JW,Wright SA,Harding JW

更新日期：1990-10-08 00:00:00

abstract：:Microinjection of the neuronal inhibitor muscimol into the midbrain lateral/dorsolateral periaqueductal gray (l/dlPAG) suppresses increases in heart rate (HR) and mean arterial pressure (MAP) evoked by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) into the dorsomedial hypothalamus (DMH...

journal_title：Brain research

authors： de Menezes RC,Zaretsky DV,Fontes MA,DiMicco JA

更新日期：2006-05-30 00:00:00