Differential effects of inorganic lead on hippocampal long-term potentiation in young rats in vivo.

Abstract:

:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in animals exposed to 500 ppm of lead. In females, LTP was significantly attenuated, while in males the LTP was identical to that of controls.

journal_name

Brain Res

journal_title

Brain research

authors

Zaiser AE,Miletic V

doi

10.1016/s0006-8993(00)02657-3

subject

Has Abstract

pub_date

2000-09-08 00:00:00

pages

201-4

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(00)02657-3

journal_volume

876

pub_type

杂志文章
  • Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse.

    abstract::We cloned the genes for the mouse homologue of the neuromedin B receptor (NMB-R) and the bombesin receptor subtype 3 (BRS-3). Both receptor genes consist of three exons with well-conserved intron-exon borders. Although the NMB-R gene spans more than 10 kb, the BRS-3 gene spans only about 4 kb. Comparison of the mouse ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00380-6

    authors: Ohki-Hamazaki H,Wada E,Matsui K,Wada K

    更新日期:1997-07-11 00:00:00

  • Ultrastructural observations of non-selective effects of ricin treatment (RCA-120) in the rat dorsal root ganglion.

    abstract::The effects of ricin (RCA-120) on non-injected dorsal root ganglion (DRG) cells, sharing the same DRG as the injected ones, were studied after ricin injections into the tibial nerve and B-HRP injections into the peroneal nerve. Numerous DRG cells containing B-HRP reaction product and exhibiting signs of advanced degen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90561-o

    authors: Rivero-Melián C,Arvidsson J

    更新日期:1990-02-19 00:00:00

  • Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells.

    abstract::Present study revealed the stimulatory effects of delta opioid receptor on intracellular Ca(2+) concentration ([Ca(2+)](i)) in SH-SY5Y cells. Fura-2 based single cell fluorescence ratio (F345/F380) was used to monitor the fluctuation of [Ca(2+)](i). Application of the selective delta-opioid receptor agonist alone, [D-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02904-8

    authors: Chen L,Zou S,Lou X,Kang HG

    更新日期:2000-11-03 00:00:00

  • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins.

    abstract::The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five major functional systems, namely the dorsal somatomotor basal ganglia; ventral viscerolimbic basal...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2011.09.037

    authors: Kuenzel WJ,Medina L,Csillag A,Perkel DJ,Reiner A

    更新日期:2011-11-18 00:00:00

  • Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics.

    abstract::Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)00904-3

    authors: Gong CX,Shaikh S,Grundke-Iqbal I,Iqbal K

    更新日期:1996-11-25 00:00:00

  • Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat.

    abstract::Increasing doses (0.1, 1.0, 10.0 mg/kg) of scopolamine were systemically (i.p.) administered to rats subjected to moderate fluid percussion brain injury. Scopolamine treatment (1.0 mg/kg, i.p.) 15 min prior to trauma significantly reduced mortality and the duration of transient behavioral suppression assessed by a var...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91104-3

    authors: Lyeth BG,Dixon CE,Hamm RJ,Jenkins LW,Young HF,Stonnington HH,Hayes RL

    更新日期:1988-05-10 00:00:00

  • The regulation of striatal DOPA synthesis by alpha 2-adrenoreceptors.

    abstract::The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90427-3

    authors: Rabey JM,Passeltiner P,Bystritsky A,Engel J,Goldstein M

    更新日期:1981-12-28 00:00:00

  • Cholinesterase activity and choline uptake in intact nerve cell cultures.

    abstract::Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90337-1

    authors: Massarelli R,Stefanovic V,Mandel P

    更新日期:1976-08-06 00:00:00

  • Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats.

    abstract::Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02263-1

    authors: Sakakibara Y,Mitha AP,Ayoub IA,Ogilvy CS,Maynard KI

    更新日期:2002-03-22 00:00:00

  • After-effects of fusimotor stimulation on spindle la afferents' dynamic sensitivity, revealed during slow movements.

    abstract::After-effects of fusimotor action on dynamic sensitivity of spindle primary afferents from soleus resulted from low rate stimulation of both static and dynamic gamma-axons. Sensitivity to small sinusoidal stretches superimposed on triangles was enhanced during triangular lengthening but not during shortening. These af...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90289-x

    authors: Baumann TK,Emonet-Dénand F,Hulliger M

    更新日期:1982-01-28 00:00:00

  • Schwann cells can misdirect regrowing neuronal processes.

    abstract::Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00501-5

    authors: Sims TJ,Gilmore SA

    更新日期:1997-07-18 00:00:00

  • NO-sGC-cGMP signaling influence the anxiolytic like effect of lithium in mice in light and dark box and elevated plus maze.

    abstract::Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.10.002

    authors: Walia V,Garg C,Garg M

    更新日期:2019-02-01 00:00:00

  • Plasticity of [14C]2-deoxy-D-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement.

    abstract::Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90442-4

    authors: Kozlowski MR,Marshall JF

    更新日期:1980-09-15 00:00:00

  • Ontogeny of neurophysin in the rat pituitary gland. An electron microscope immunohistochemical study.

    abstract::The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90007-5

    authors: Leclerc R,Pelletier G

    更新日期:1977-07-01 00:00:00

  • Fetally-induced noradrenergic hyperinnervation of cerebral cortex results in persistent down-regulation of beta-receptors.

    abstract::Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(82)90195-x

    authors: Beaulieu M,Coyle JT

    更新日期:1982-08-01 00:00:00

  • Cortical spreading depression reduces paraventricular activation induced by hippocampal neostigmine injection.

    abstract::The firing rate of the neurons of the hypothalamic paraventricular nucleus, the temperatures of the interscapular brown adipose tissue and of the colon (TIBAT and Tc) were monitored in 24 urethane-anesthetized male Sprague-Dawley rats divided into four groups. These variables were measured before and after hippocampal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01227-5

    authors: Monda M,Viggiano A,Sullo A,De Luca V

    更新日期:1999-04-03 00:00:00

  • Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease.

    abstract::Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.10.066

    authors: Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

    更新日期:2013-01-23 00:00:00

  • Afferent projections related to attack sites in the pontine tegmentum.

    abstract::Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90009-x

    authors: Smith DA,Flynn JP

    更新日期:1979-03-23 00:00:00

  • The clustered cell system is present before formation of the ACh patches in the intermediate gray layer of the cat superior colliculus.

    abstract::Projection neurons from the superior colliculus (SC) to the cuneiform region (CFR) of the midbrain form distinct cell clusters in the intermediate gray layer which precisely overlap the cholinergic fiber patches in this region of the cat SC (Jeon and Mize, J. Comp. Neurol., 337 (1993) 127-150). The acetylcholine (ACh)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00563-x

    authors: Banfro FT,Mize RR

    更新日期:1996-09-16 00:00:00

  • Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.

    abstract::To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91044-8

    authors: Overstreet DH,Russell RW,Crocker AD,Schiller GD

    更新日期:1984-03-05 00:00:00

  • beta-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells.

    abstract::We investigated the effect of beta-estradiol (E2) on synaptogenesis in the hippocampus using organotypic hippocampal slice cultures and subregional hippocampal neuron cultures. E2 increased the expression of PSD95, a postsynaptic marker, specifically in stratum lucidum of Cornu Ammonis 3 (CA3SL) in cultured hippocampa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.02.093

    authors: Sato K,Akaishi T,Matsuki N,Ohno Y,Nakazawa K

    更新日期:2007-05-30 00:00:00

  • The fate of "dark" neurons produced by transient focal cerebral ischemia in a non-necrotic and non-excitotoxic environment: neurobiological aspects.

    abstract:BACKGROUND INFORMATION:We recently proposed novel neurobiological ideas for discussion regarding the common nature (malfunction of a physicochemical phenomenon genetically programmed for the morphological execution of ontogenetic apoptosis), mechanism of formation (phase transition in an intraneuronal gel structure) an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.02.011

    authors: Kövesdi E,Pál J,Gallyas F

    更新日期:2007-05-25 00:00:00

  • The population of the dorsal root ganglion cells which have central processes in ventral root and their immunoreactivity.

    abstract::Axonal transport of fluorescent dyes applied to the cut distal ends of rat L4 dorsal and ventral spinal roots was studied in order to characterize the population of dorsal root ganglion (DRG) neurons emitting axons entering the ventral root. Ca. 9% of DRG neurons, principally of small or medium size, can be labeled fr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90053-9

    authors: Fang XB

    更新日期:1987-02-03 00:00:00

  • Synaptic transmission elevates adenosine 3', 5'-monophosphate (cyclic AMP) in locust neurosecretory cells.

    abstract::The release of adipokinetic hormones from the neurosecretory cells within the glandular lobe of the corpus cardiacum (CC) of locusts is under the synaptic control of axons within the nervi corporis cardiaca II (NCC II). This synapse has been shown to be aminergic with the transmitter tentatively identified as octopami...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91242-8

    authors: Orchard I,Loughton BG,Gole JW,Downer RG

    更新日期:1983-01-03 00:00:00

  • Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model.

    abstract::Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.10.089

    authors: Kang JM,Park HJ,Choi YG,Choe IH,Park JH,Kim YS,Lim S

    更新日期:2007-02-02 00:00:00

  • Expression of the immediate-early gene egr-1 and substance P in the spinal cord following locomotor training in adult rats.

    abstract::The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.041

    authors: Nunes AC,Duarte RB,Sousa TB,dos Santos JR,Freire MA,Costa MS

    更新日期:2010-07-23 00:00:00

  • Sex hormone binding globulin stimulates female sexual receptivity.

    abstract::Sex hormone binding globulin (SHBG) is found in the brain and acts directly on plasma membrane-associated receptors in the prostate gland. Infusing SHBG into the medial preoptic area or medial basal hypothalamus of female rats increases their female sexual receptivity. SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E pl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02569-5

    authors: Caldwell JD,Moe BD,Hoang J,Nguyen T

    更新日期:2000-08-18 00:00:00

  • Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys.

    abstract::It has been demonstrated that repeated, subcutaneous administration of 3,4-methylenedioxymethamphetamine (MDMA) to rats, guinea pigs, and squirrel monkeys produces long-lasting depletions of serotonin (5-hydroxytryptamine; 5-HT) in several brain regions. Since evidence of degenerating 5-HT neurons has been observed in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90700-2

    authors: Kleven MS,Woolverton WL,Seiden LS

    更新日期:1989-05-29 00:00:00

  • Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites.

    abstract::The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90395-2

    authors: Kruger L,Mantyh PW,Sternini C,Brecha NC,Mantyh CR

    更新日期:1988-11-01 00:00:00

  • Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration.

    abstract::Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91452-7

    authors: Piazza PV,Rougé-Pont F,Deminière JM,Kharoubi M,Le Moal M,Simon H

    更新日期:1991-12-13 00:00:00