Abstract：
:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol formation that occurs after androgen administration to castrated males. Therefore, we have re-examined the induction mechanism using a direct in vitro assay of aromatase activity. Since levels of aromatase activity and enzyme kinetics were similar irrespective of the assay used, we can conclude that increased estradiol formation after androgen stimulation is mainly due to enzyme induction and that estrogen binding and/or metabolism do not interfere significantly with the induction process.
journal_name
Brain Resjournal_title
Brain researchauthors
Steimer T,Hutchison JBdoi
10.1016/0006-8993(89)90203-5subject
Has Abstractpub_date
1989-02-20 00:00:00pages
335-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90203-5journal_volume
480pub_type
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