Abstract：
:The peptide NK1-receptor antagonists, sendide and [D-Trp7]sendide, have been evaluated for antinociceptive activity in the capsaicin test. Both peptides, injected intrathecally (i.t.) 5 min prior to intraplantar capsaicin, produced a dose-dependent reduction of the capsaicin-induced paw licking response. Naloxone (4.0 mg/kg) pretreatment did not affect sendide- and [D-Trp7]sendide-induced antinociception, whereas naloxone at a dose of 0.5 mg/kg antagonized the antinociceptive effect of i.t. administered morphine. Conversely, the antinociceptive action induced by both NK1-receptor antagonists was reduced significantly by i.t. co-administration of substance P. Morphine-induced antinociception was not antagonized by co-administration of substance P. These results led us to the understanding of differential action mechanism of NK1-receptor antagonist- and morphine-induced antinociception as assayed by the capsaicin test.
journal_name
Brain Resjournal_title
Brain researchauthors
Sakurada T,Yogo H,Katsumata K,Tan-No K,Sakurada S,Kisara K,Ohba Mdoi
10.1016/0006-8993(94)91080-4subject
Has Abstractpub_date
1994-06-27 00:00:00pages
319-22issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91080-4journal_volume
649pub_type
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