Cholinergic activation of medial pontine reticular formation neurons in vitro.

abstract：:Activation of phospholipase C (PLC) coupled to phosphoinositide (PtdIns) hydrolysis occurs through one of the two pathways. One of the major pathways for the neurotransmitter signaling involves phosphoinositide (PtdIns) specific and G-protein dependent PLC-beta, which stimulates the formation of inositol triphosphate ...

journal_title：Brain research

authors： Narang N,Joseph JA,Ayyagari PV,Gerber M,Crews FT

更新日期：1996-02-05 00:00:00

abstract：:The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...

journal_title：Brain research

authors： Kehoe J,Sealock R,Bon C

更新日期：1976-05-14 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:Responses of antennal olfactory receptors of the Colorado potato beetle (Leptinotarsa decemlineata Say) to stimulation with 5 general green odour components, i.e. cis-3-hexen-1-ol, trans-2-hexenal, cis-3-hexenyl acetate, trans-2-hexen-1-ol and 1-hexanol, were recorded extracellularly. Response spectra derived from the...

journal_title：Brain research

authors： De Jong R,Visser JH

更新日期：1988-04-26 00:00:00

abstract：:Locally applied ciliary neurotrophic factor (CNTF) has a powerful effect on retrograde axonal reaction following facial nerve crush in neonatal rats. We examined whether it also exerts a strong effect on retrograde axonal reaction in young adult rats when administered subcutaneously. The dose was 1 mg/kg body weight, ...

journal_title：Brain research

authors： Ulenkate HJ,Gispen WH,Jennekens FG

更新日期：1996-04-22 00:00:00

abstract：:Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...

journal_title：Brain research

authors： Holbrook PG,Baum MJ

更新日期：1983-03-01 00:00:00

abstract：:Three to five microliters of 50% HRP in saline was injected along a central axis into one of the 6 extraocular muscles in each of 18 adult pigeons. The brain was fixed and serially sectioned 16-20 h postinjection and the HRP reacted with tetramethylbenzidine (TMB). HRP-labeled proprioceptive neurons were located in th...

journal_title：Brain research

authors： Eden AR,Correia MJ,Steinkuller PG

更新日期：1982-04-08 00:00:00

abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...

journal_title：Brain research

authors： Khojasteh F,Nahavandi A,Mehrpouya S,Homberg JR,Mirzamohammadi S,Raufi S,Soleimani M,Barati M

更新日期：2015-01-30 00:00:00

abstract：:The effects of the 8-alpha-amino-ergoline CU 32-085 on central dopamine neuronal systems was investigated. Two h after administration of CU 32-085 a slight increase of dopamine levels was observed in the nucleus caudatus-putamen. Radioligand binding studies in vitro have shown that CU 32-085 has a low affinity for str...

journal_title：Brain research

authors： Fuxe K,Agnati L,Mascagni F,Kuga S,Helmer-Matyjek E,Goldstein M

更新日期：1985-03-04 00:00:00

abstract：:Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...

journal_title：Brain research

authors： Tai KK,Truong DD

更新日期：2007-02-16 00:00:00

abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...

journal_title：Brain research

authors： Neal AP,Stansfield KH,Guilarte TR

更新日期：2012-02-23 00:00:00

abstract：:Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response ...

journal_title：Brain research

authors： Meder WP,Dooley DJ

更新日期：2000-09-01 00:00:00

abstract：:In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...

journal_title：Brain research

authors： Mandelbrod I,Feldman S,Werman R

更新日期：1983-08-22 00:00:00

abstract：:Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spon...

journal_title：Brain research

authors： Adibhatla RM,Hatcher JF

更新日期：2007-02-23 00:00:00

abstract：:The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...

journal_title：Brain research

authors： Parent A,Csonka C,Etienne P

更新日期：1984-01-16 00:00:00

abstract：:The distribution of NK(1) receptor immunoreactivity in the amygdaloid complex, induction of NK(1) receptor endocytosis in the amygdala following immobilisation stress, and the ability of pretreatment with the substance P antagonist L-760,735 or imipramine to block this response were examined in gerbils, a species with...

journal_title：Brain research

authors： Smith DW,Hewson L,Fuller P,Williams AR,Wheeldon A,Rupniak NM

更新日期：1999-11-27 00:00:00

abstract：:The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articul...

journal_title：Brain research

authors： Zhang WS,Xu H,Xu B,Sun S,Deng XM,Zhang YQ

更新日期：2009-04-06 00:00:00

abstract：:Brain protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) activities are adaptable to changes of peripheral blood glucose level in vivo. GSK-3 phosphorylates microtube-associated protein tau at multiple sites, which can be antagonized by protein phosphatase-2A (PP-2A). The imbalance among these enzymes might...

journal_title：Brain research

authors： Qu Z,Jiao Z,Sun X,Zhao Y,Ren J,Xu G

更新日期：2011-04-06 00:00:00

abstract：:The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...

journal_title：Brain research

authors： Fellows LK,Boutelle MG

更新日期：1993-02-26 00:00:00

abstract：:Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...

journal_title：Brain research

authors： Han MF,Livesey PJ

更新日期：1977-04-15 00:00:00

abstract：:In order to investigate protein function in rat primary cortical neuronal cultures, we modified an adenoviral vector expression system and assessed the strength and specificity of the cytomegalovirus (CMV), rous sarcoma virus (RSV), and rat and human synapsin 1 (SYN1) promoters to drive DsRed-X expression. We also inc...

journal_title：Brain research

authors： Boulos S,Meloni BP,Arthur PG,Bojarski C,Knuckey NW

更新日期：2006-08-02 00:00:00

abstract：:In male hamsters mating behavior is dependent on chemosensory input from the main olfactory and vomeronasal systems, whose central pathways contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH) neurons. In sexually naive males, vomeronasal organ removal (VNX), but not main olfactory lesions, impairs ...

journal_title：Brain research

authors： Blake CB,Meredith M

更新日期：2010-03-04 00:00:00

abstract：:Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present stud...

journal_title：Brain research

authors： Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen L

更新日期：2006-07-07 00:00:00

abstract：:The laminin-alpha2 chain is a component of brain capillary basement membranes and appears also to be present in neurons of rat, rabbit, pig and non-human primate brain as evidenced by immunohistochemistry. In the present study, we have further characterized this very distinct neuronal laminin-alpha2 chain-like immunor...

journal_title：Brain research

authors： Tian M,Hagg T,Denisova N,Knusel B,Engvall E,Jucker M

更新日期：1997-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...

journal_title：Brain research

authors： Curvello V,Hekierski H,Pastor P,Vavilala MS,Armstead WM

更新日期：2017-09-01 00:00:00

abstract：:Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...

journal_title：Brain research

authors： Lavond DG,Logan CG,Sohn JH,Garner WD,Kanzawa SA

更新日期：1990-04-30 00:00:00

abstract：:Zebrafish as a neurogenetic model system depends on the correct neuroanatomical understanding of its brain organization. Here, we address the unresolved question regarding a possible zebrafish homologue of the dorsal pallial division, the region that in mammals gives rise to the isocortex. Analyzing the distributions ...

journal_title：Brain research

authors： Mueller T,Dong Z,Berberoglu MA,Guo S

更新日期：2011-03-24 00:00:00

abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...

journal_title：Brain research

authors： Simon NW,Moghaddam B

更新日期：2017-01-01 00:00:00

abstract：:The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...

journal_title：Brain research

authors： Zhang G,Assadi AH,Roceri M,Clark GD,D'Arcangelo G

更新日期：2009-04-24 00:00:00

abstract：:Previous studies have shown that pyramidal neurons in hippocampal regions CA1 and CA3 are selectively vulnerable in several neurodegenerative disorders and that a subpopulation of pyramidal neurons in cell cultures of embryonic hippocampus are sensitive to glutamate neurotoxicity. In order to determine whether the pat...

journal_title：Brain research

authors： Mattson MP,Kater SB

更新日期：1989-06-19 00:00:00