Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat.

abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...

journal_title：Brain research

authors： Pérez-Otaño I,Herrero MT,Oset C,De Ceballos ML,Luquin MR,Obeso JA,Del Río J

更新日期：1991-12-13 00:00:00

abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...

journal_title：Brain research

authors： Maccari S,Piazza PV,Deminière JM,Angelucci L,Simon H,Le Moal M

更新日期：1991-05-10 00:00:00

abstract：:Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...

journal_title：Brain research

authors： Beyaert CA,Hill JM,Kaufman MP

更新日期：1997-06-06 00:00:00

abstract：:The effects of the GABAA agonist, isoguvacine, on NMDA-induced burst firing of substantia nigra dopaminergic neurons were studied with intracellular and whole cell recordings in vitro. NMDA application caused the neurons to fire in rhythmic bursts. Although the NMDA-induced bursty firing pattern was insensitive to hyp...

journal_title：Brain research

authors： Paladini CA,Iribe Y,Tepper JM

更新日期：1999-06-19 00:00:00

abstract：:Immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. This innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arisi...

journal_title：Brain research

authors： Parent A,Smith Y

更新日期：1987-11-24 00:00:00

abstract：:Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...

journal_title：Brain research

authors： Gilbert ME,Mack CM

更新日期：1990-06-11 00:00:00

abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

journal_title：Brain research

authors： Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

更新日期：2015-05-22 00:00:00

abstract：:A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...

journal_title：Brain research

authors： Rukenstein A,Greene LA

更新日期：1983-03-14 00:00:00

abstract：:An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...

journal_title：Brain research

authors： Bracha HS,Seitz DJ,Otemaa J,Glick SD

更新日期：1987-05-19 00:00:00

abstract：:The immunolocalization of the 14-3-3 eta isoform in the anterior horn cells (AHCs) of patients with sporadic amyotrophic lateral sclerosis (ALS) and controls was examined. Compared with the immunolocalization of other 14-3-3 isoforms, the immunolocalization of the 14-3-3 eta isoform was either synaptic at the peripher...

journal_title：Brain research

authors： Umahara T,Uchihara T,Shibata N,Nakamura A,Hanyu H

更新日期：2016-09-01 00:00:00

abstract：:Unitary discharges in the efferent ciliary nerves were studied in cervical sympathectomized rabbits. In all, 279 units were recorded and categorized, except 7 units, into the following 3 types from their responses to photic and other stimuli, i.e. type A (170 units), type B (42 units) and type C (60 units). Type A uni...

journal_title：Brain research

authors： Inoue T

更新日期：1980-03-17 00:00:00

abstract：:The effects of selective dopamine antagonists on the pentazocine-like discriminative stimulus effects of morphine were investigated in the rat trained to discriminate 3.0 mg/kg of pentazocine from vehicle. Morphine (3.0 mg/kg), a mu-selective agonist, produced stimulus effects in common with pentazocine (3.0 mg/kg), i...

journal_title：Brain research

authors： Ukai M,Hiraiwa E,Kameyama T

更新日期：1991-02-08 00:00:00

abstract：:The triggering of ectopic action potentials (APs) at axon terminals in a chronic epileptic cobalt focus was investigated in thalamocortical (TC) neurons of rats under urethane anesthesia. TC cells which were in register with an active epileptic aggregate discharged bursts of 2-11 APs. According to the rules of the col...

journal_title：Brain research

authors： Pinault D

更新日期：1992-03-27 00:00:00

abstract：:Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...

journal_title：Brain research

authors： Walmsley B,Tracey DJ

更新日期：1981-10-26 00:00:00

abstract：:Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role in ischemic stroke. The present study characterized the effe...

journal_title：Brain research

authors： Turner RJ,Helps SC,Thornton E,Vink R

更新日期：2011-06-01 00:00:00

abstract：:Exposure of hippocampal slices to Mg2+ free media (0 Mg) has been shown to trigger full production of stimulus-induced seizure activity after restoration of physiological conditions [1]. In the present study employing hippocampal entorhinal cortical slices (HEC), spontaneous epileptiform discharges (SEDs) were induced...

journal_title：Brain research

authors： Vick RS,Rafiq A,Coulter DA,Jakoi ER,DeLorenzo RJ

更新日期：1996-05-20 00:00:00

abstract：:To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neur...

journal_title：Brain research

authors： Scammell TE,Price KJ,Sagar SM

更新日期：1993-08-06 00:00:00

abstract：:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...

journal_title：Brain research

authors： Toledo CA,Britto LR,Pires RS,Veenman CL,Reiner A

更新日期：2002-08-23 00:00:00

abstract：:The responsiveness of the tonically firing single motor units (SMU) to Ia afferent volleys elicited by either mechanical (T-reflex) or electrical nerve stimulation (H-reflex) was tested in the extensor carpi radialis muscle (ECR) while the subjects were maintaining a steady wrist extension force using visual feedback ...

journal_title：Brain research

authors： Nafati G,Rossi-Durand C,Schmied A

更新日期：2004-08-27 00:00:00

abstract：:Using a co-culture model, we showed that diffusible factors from arcuate nucleus (AN) specifically increased the number and the size of hypothalamic neurons producing melanin-concentrating hormone (MCH). In this model neurite outgrowth and contacts between MCH neurons and dopaminergic neurons were also prominently inc...

journal_title：Brain research

authors： Compagnone N,Fellmann D,Bugnon C,Jaquemard C

更新日期：1993-11-19 00:00:00

abstract：:Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

journal_title：Brain research

authors： Kozlowski MR,Marshall JF

更新日期：1980-09-15 00:00:00

abstract：:Double immunostaining for c-fos and oxytocin (OXY) was used to study the topography and time course of the metabolic activation of the hypothalamic oxytocinergic system upon osmotic stress in the male rat. Animals injected i.p. with hypertonic saline expressed c-fos-like immunoreactivity (FLI) in the paraventricular (...

journal_title：Brain research

authors： Giovannelli L,Shiromani PJ,Jirikowski GF,Bloom FE

更新日期：1992-08-14 00:00:00

abstract：:In the neocortex, fast excitatory synaptic transmission can typically be blocked by using excitatory amino acid (EAA) receptor antagonists. In recordings from layer II/III neocortical pyramidal neurons, we observed an evoked excitatory postsynaptic potential (EPSP) or current (EPSC) in the presence of EAA receptor ant...

journal_title：Brain research

authors： Chu ZG,Zhou FM,Hablitz JJ

更新日期：2000-12-29 00:00:00

abstract：:Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that regulate innervating sympathetic neurons. Here, we used western blot analysis to investigate changes in NGF and NT-3 protein in several peripheral tissues following loss of sympathetic input. Following removal of the superior cervical...

journal_title：Brain research

authors： Randolph CL,Bierl MA,Isaacson LG

更新日期：2007-05-04 00:00:00

abstract：:Following extirpation of three quarters of the eye anlage of Xenopus laevis in stage 33/34, the remaining quadrants developed into small eyes of normal shape. Irrespective of the different portions of the eye anlage the quarter eyes originated from, the retinotectal projection was always confined to the rostrolateral ...

journal_title：Brain research

authors： Degen N,Brändle K

更新日期：1986-09-01 00:00:00

abstract：:The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...

journal_title：Brain research

authors： Linthorst AC,van Giersbergen PL,Gras M,Versteeg DH,de Jong W

更新日期：1994-03-14 00:00:00

abstract：:Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...

journal_title：Brain research

authors： Raine CS,Wiśniewski HM,Iqbal K,Grundkeiqbal I,Norton WT

更新日期：1977-01-21 00:00:00

abstract：:This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...

journal_title：Brain research

authors： Kim EM,Welch CC,Grace MK,Billington CJ,Levine AS

更新日期：1998-09-21 00:00:00

abstract：:In normal adult cats we measured the density of staining for the activity of succinate dehydrogenase (SDH staining) in ventral horn cells of different sizes. The measurements were restricted to that part of the lumbar ventral horn (L6-L7) which is known to contain motoneurones of the peroneal nerve. A statistically si...

journal_title：Brain research

authors： Donselaar Y,Kernell D,Eerbeek O

更新日期：1986-10-15 00:00:00

abstract：:Cardiovascular responses to electrical microstimulation of the ventrolateral medulla were investigated in both Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) under pentobarbital anesthesia. The threshold intensity required to elicit a change in blood pressure (BP) and the cardiovascular responses in...

journal_title：Brain research

authors： Chan RK,Chan YS,Wong TM

更新日期：1990-07-02 00:00:00