Abstract：
:The effects of the GABAA agonist, isoguvacine, on NMDA-induced burst firing of substantia nigra dopaminergic neurons were studied with intracellular and whole cell recordings in vitro. NMDA application caused the neurons to fire in rhythmic bursts. Although the NMDA-induced bursty firing pattern was insensitive to hyperpolarization by current injection, it was reversibly abolished by the selective GABAA agonist, isoguvacine. The block of the rhythmic burst pattern by isoguvacine application occurred regardless of whether the chloride reversal potential was hyperpolarizing (ECl-=-70 mV) or depolarizing (ECl-=-40 mV). In either case, the input resistance of the dopaminergic neurons was dramatically decreased by application of isoguvacine. It is concluded that GABAA receptor activation by isoguvacine disrupts NMDA receptor-mediated burst firing by increasing the input conductance and thereby shunting the effects of NMDA acting at a distally located generator of rhythmic burst firing.
journal_name
Brain Resjournal_title
Brain researchauthors
Paladini CA,Iribe Y,Tepper JMdoi
10.1016/s0006-8993(99)01484-5subject
Has Abstractpub_date
1999-06-19 00:00:00pages
145-51issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01484-5journal_volume
832pub_type
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