Abstract：
:We report the localization of angiotensin-converting enzyme (kininase II, EC 3.4.15.1) in discrete nuclei and areas of the rat brain by a quantitative autoradiographic technique using image processing coupled to computerized microdensitometry, after incubation of brain sections with the specific converting enzyme inhibitor [125I]351A. High angiotensin-converting enzyme levels are present in circumventricular organs (organon subfornicalis and area postrema), the choroid plexus, and extrapyramidal areas (nucleus caudatus, globus pallidus and substantia nigra) with intermediate levels in selected hypothalamic, septal, habenular and brainstem nuclei. Our results support the idea that angiotensin II could be formed in specific brain areas, both outside and inside the blood-brain barrier. In other brain structures, such as the extrapyramidal areas, kininase II could be involved in the processing or metabolism of other brain peptides.
journal_name
Brain Resjournal_title
Brain researchauthors
Correa FM,Plunkett LM,Saavedra JMdoi
10.1016/0006-8993(86)90746-8subject
Has Abstractpub_date
1986-06-11 00:00:00pages
259-66issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90746-8journal_volume
375pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuronal synaptic functions in physiological and pathological conditions. Many studies, over the past years, have shown that it is actively involved in PD pathophysiology. Alpha-synuclein is integrated in a complex network o...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.04.014
更新日期：2012-10-02 00:00:00
abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91311-n
更新日期：1991-04-05 00:00:00
abstract：:We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01505-9
更新日期：1998-03-16 00:00:00
abstract：:Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.015
更新日期：2009-03-19 00:00:00
abstract：:We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E2. Indwelling cannulas in the third ventricle of lambs (age, 5-31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for radioimmunoassay of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00946-n
更新日期：1995-11-27 00:00:00
abstract：:Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. Thes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01165-7
更新日期：1997-12-19 00:00:00
abstract：:The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.084
更新日期：2010-04-06 00:00:00
abstract：:The release of amino acids in the locus coeruleus (LC) of conscious, freely moving rats was studied in time periods of 3 min by use of push-pull superfusion under basal conditions and during application of various experimental stimuli known to influence the activity of the LC-noradrenergic system. Tail pinch for 3 min...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01102-1
更新日期：1995-12-15 00:00:00
abstract：:Injection of a potent, cholinergic muscarinic antagonist, [3H]3-quinuclidinyl benzilate ([3H]QNB), results in a localization of the drug to muscarinic receptors in rat brain. The distribution of these drug receptors was examined in various brain regions previously thought to contain cholinergic neurons. They were loca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90399-1
更新日期：1976-07-09 00:00:00
abstract：:Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90782-4
更新日期：1981-09-28 00:00:00
abstract：:Somatostatin-like immunoreactivity (Som-LI) and glycine high-affinity uptake have been characterized in the Rana pipiens retina. These labels are found in both the outer and inner plexiform layers (OPL and IPL), suggesting that interplexiform cells (IPCs) contain both Som and glycine in this retina. In double-label ex...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91215-8
更新日期：1989-08-21 00:00:00
abstract：:Movement of fragmented DNA in dendrites of retinal neurons during the apoptotic cell death was investigated. The time-course of the movement of fragmented DNA in dendrites of retinal neurons undergoing apoptotic cell death induced by intravitreal N-methyl-d-aspartate (NMDA) injection were examined by in situ terminal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.075
更新日期：2004-05-08 00:00:00
abstract：:Mice pretreated with the benzodiazepine antagonist, CGS 8216 (2.5, 10, or 40 mg/kg, i.p.) learned a T-maze discrimination to a fixed performance criterion more rapidly than vehicle-treated mice. In retention tests conducted one week later, the drug-treated groups had better first-trial recall and greater difficulty re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91223-1
更新日期：1988-09-13 00:00:00
abstract：:Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91538-4
更新日期：1993-12-24 00:00:00
abstract：:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03160-8
更新日期：2002-09-13 00:00:00
abstract：:The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90142-6
更新日期：1976-05-14 00:00:00
abstract：:The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90287-2
更新日期：1985-05-27 00:00:00
abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90244-7
更新日期：1987-09-08 00:00:00
abstract：:The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146697
更新日期：2020-05-01 00:00:00
abstract：:Systemic administration of nicotinic receptor (nAChR) agonists is antinociceptive in models of acute pain whereas their intrathecal (i. t.) administration has been reported to be antinociceptive, nociceptive or without effect. It has been hypothesized that the action induced is dependent upon the subtype and location ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02472-0
更新日期：2000-07-28 00:00:00
abstract：:In terrestrial gastropod mollusks (slugs and snails), olfaction is the dominant sensory modality guiding various kinds of behavior. Anatomical studies indicate that olfactory information is processed in the brain (the cerebral ganglion) in two lobes in particular: the procerebrum (PC) and the metacerebrum (MtC). This ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.112
更新日期：2008-09-22 00:00:00
abstract：:Correlative light and electron microscopic methods were used to examine the morphology, distribution and synaptic connections of double bouquet cells immunoreactive for the calcium-binding protein calbindin D-28k in the human temporal neocortex. Double bouquet cells form symmetric synapses with small dendritic shafts ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00641-3
更新日期：1995-08-28 00:00:00
abstract：:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.060
更新日期：2011-09-02 00:00:00
abstract：:It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90618-6
更新日期：1980-01-13 00:00:00
abstract：:The suprachiasmatic nuclei (SCN) contain the major pacemaker for mammalian circadian rhythms. The SCN receive photic input both directly, via the retinohypothalamic tract (RHT), and indirectly, via the geniculohypothalamic tract (GHT), which originates in cells in the intergeniculate leaflet (IGL) and anterior portion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91163-3
更新日期：1989-07-31 00:00:00
abstract：:The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphism...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03849-0
更新日期：2003-01-24 00:00:00
abstract：:Natural stimulation was used to map the receptive fields of single cells recorded from the rostral medial portion of the dorsal accessory olive (rDAO) and the subjacent principal olive (PO) of the barbiturate anesthetized cat. Previous reports indicated a somatotopic mapping of the entire contralateral body within the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91742-b
更新日期：1993-03-12 00:00:00
abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00654-9
更新日期：1997-08-08 00:00:00
abstract：:Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.10.062
更新日期：2015-01-21 00:00:00
abstract：:Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total dis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90039-9
更新日期：1986-09-24 00:00:00
